Neuropharmacology of Hypertension
Chris Shaich,Ellen Tommasi,Kenya DoNascimento,Dr.Diz,Allyson Marshall,Messia Steed,Manisha Nautiyal
Debra I. Diz, PhD
The objective of my laboratory is to investigate the mechanistic relation between the brain and kidney in the long-term control of arterial pressure and body fluid volume. Our lab explores the normal function of specific peptidergic systems that interact with cardiovascular reflex areas of the brain by examining interactions of neurotransmitters at specific brain sites. We also investigate the pathological changes that occur in these systems that lead to hypertension. We use neuropharmacolological and physiological approaches, in vitro receptor autoradiography and in situ hybridization and immunohistochemistry. Another area we examine is the interaction of the neural and hormonal system with the kidney, looking at renal ischemia and hypertension. Current projects focus on the role of the brain and renal renin-angiotensin-aldosterone systems in hypertension and obesity during aging. Collaborations with other Hypertension Center labs expand my neuropharmacological approach to include exploring cardiovascular function from the cellular to the whole animal level. New projects assess autonomic function in humans using non-invasive approaches.
Manuscript Featured As Podcast: A manuscript by Hypertension & Vascular Research Center members was featured as an AJP-Heart and Circulatory Physiology podcast. These exciting editorial podcasts offer conversations between authors and editors, highlighting the hottest papers published in AJP-Heart and Circulatory Physiology, opening new avenues for cardiovascular investigation. Listen to the podcast.