News & Recognitions
Several of our PREP (Post-baccalaureate Research Education
Program) students within Hypertension and Vascular Research have been
accepted to various Universities upon completion of the PREP at the end of
July. Congratulations to the following students:
Ashley Smith working
with Dr. David Soto Pantoja has been accepted into the PhD Programs at
Vanderbilt University and Wake Forest University; Sierra Nance working with Dr. TanYa Gwathmey has
been accepted into the PhD Program at the University of Michigan – Ann
Arbor; Sierra Patterson working
with Dr. Tina Brinkley has been accepted into a Masters of Science in Public
Health at Emory University; Lillian Zerihun working with Dr. TanYa Gwathmey
has been accepted into the MD/MPH Program at Columbia University.
Congratulations to Dr.
Andrew South, who has
received a Pilot Award funded by the Cardiovascular Sciences Center (CVSC)
Pilot Fund Committee. The title of the proposal is “Role of the
Renin-Angiotensin System in Pediatric Essential Hypertension”.
Anya Brown, Clinical Research Coordinator with Hypertension and
Vascular Research, organized a blood pressure screening booth for the
“Share the Health” health fair run by WFSM Medical Students that was held in
January. Dr. Hossam
Shaltout, Omar Shaltout,
Anya Brown, Sara Arenas DeLeon (PREP
Student) and IPP student Erica
Ortiz provided blood pressure
screenings for over 100 participants with 20% being referred to
Physicians for follow-up on their blood pressure and possible diabetes.
IPP Graduate Student Marianne
Collard, working withDrs. Ann Tallant and Patricia Gallagher, has been selected to present her
poster,“Mechanisms of Action and Molecular Targets of Dietary Bioactive
Components” for the American Society for Nutrition’s Emerging Leader Poster
Competition at the upcoming 2017 Experimental Biology Conference in Chicago in
April as well as present her studies at a podium presentation at the
Experimental Biology Conference.
IPP Graduate Student Omeed
Rahimi, working withDrs. Ann Tallant and Patricia Gallagher, has co-founded a company (Encepheal
Therapeutics) that received a Phase 1 SBIR (Small Business Innovation Research)
Grant for 300K to fund the preclinical development of a therapeutic for cocaine
Neuroscience Graduate Student Alexa
Hendricks, working with Dr. Debra Diz, will have an oral presentation and a
poster for the “Perinatal Therapeutics and the Programming of Adult
Cardiometabolic Disease” symposium at the 2017 Experimental Biology Conference in April in Chicago. She will
be participating in the ASPET Student/postdoc poster competition and was awarded
a travel award from the ASPET Mentoring Network: Coaching and Career
Development Program. Her titled abstract is “Fetal Betamethasone Exposure
Markedly Attenuates the Protein Expression of Angiotensin Converting Enzyme 2
but not Dipeptidyl Peptidase 3 within the Brain Dorsomedial Medulla of Adult
Marianne Collard, Jessica Mackert and Alexa Hendricks all received Alumni Travel Awards for
their presentations at the upcoming 2017 Experimental Biology Conference in
Chicago in April.
Dr. Liliya Yamaleyeva will
present studies on photoacoustic imaging of placental oxygenation as podium
oral presentations at two upcoming meetings: Society for Reproductive
Investigation’s 64th Annual
Scientific Meeting in Orlando, Florida and a Symposium at the 2017 Experimental
Biology Conference in Chicago in April.
Dr. David Soto-Pantoja was selected as the Mid-Atlantic Research
Program Symposium (MAPRS) Outstanding PREP Alumnus. The MAPRS is held
annually among regional institutions who offer Post-baccalaureate Research
Program (PREP) or Initiative for Maximizing Student Development (IMSD)
Programs. WFSM PREP alumni have won 3 of the past 5 annual alumni awards.
Dr. Katherine Cook was
invited to speak at the ACEA Biotechnologies Biosciences Immunotherapy
Symposium at the end of March in Washington DC.
Dr. Katherine Cook has
co-authored “Lifetime Genistein Intake Increases the Response of Mammary
Tumors to Tamoxifen in Rats” for the February 2017 Clinical Cancer
Hypertension and Vascular Research celebrated Women’s Heart
Month with the “Buy a Heart, Give a Heart”. With every $1 donation, a Red
Heart was displayed in the hall of 6 Hanes. An $87 donation to the
American Heart Association in Honor of Dr.
Bridget Brosnihan’s research in
Women’s Health was made. Great Job Amy
Sharpe for leading this
effort for Hypertension!!
Hypertension and Vascular Research held their Annual Go Red:
Women’s Health Symposium on Tuesday, February 14th, 2017. This
year the event honored Dr. Bridget Brosnihan’s dedication to Women’s Health
Research. Guest speakers included Dr.
Katherine Sandberg (Georgetown
University), Dr. Lauren Anton Farrington(University of Pennsylvania), Dr.
Liomar Neves (CorDynamics, Inc.) Dr. Lisa Cassis (University of
Academic Journeys Seminar Series with Dr. Carlos Rodriguez was held Thursday, 2/9/2017 (4-5)
followed by cheese and wine reception at Biotech Place. Dr. Rodriguez provided an overview of his career
choices that put him on the path to his current position. The
presentation was well attended by trainees at various stages of their careers.
Dr. Patricia Gallagher was the invited speaker for the March
Hypertension & Vascular Research Seminar series. She updated us on
the progress of studies on the effect of a muscadine grape extract on
prostate/breast cancer and associated morbidities supported by a large donation
from an anonymous donor. Both preclinical and clinical investigations are
progressing, as planned. The Phase 1 clinical trial continues to accrue
patients, to provide data on dosing and safety, and Phase 2 protocols are in
development, with plans to open trials in breast and prostate cancer in the
coming year. Preclinical studies are providing support for the clinical trials,
by demonstrating safety and efficacy in rodent models, defining mechanisms of
action, and identifying novel responses to treatment with the extract in
chronic disease models. Data have been presented at meetings in the
spring and fall of 2016 and will be presented at several national meetings this
spring, with manuscripts to follow. She expressed appreciation for the
team contributing to the progress of the project, including clinical colleagues
and their staff for participating in the clinical studies and basic research
colleagues and their teams for continuing research efforts. Finally, she
expressed appreciation to the generous donor, who provides the support for
these translational studies out of a personal interest in knowing whether these
products are effective and who has no affiliation with the company that
manufactures the investigational extract.
Available: Associate Editor, Dr. Debra Diz, American Journal of Physiology:
Heart and Circulatory Physiology, interviews Dr.
Tatiana Baranova about her
article on the genetics of vascular responses to the diving reflex in
humans. This is a first-ever podcast recorded in both Russian and
English. Debra I. Diz (Wake
Forest University School of Medicine), lead author Tatiana I. Baranova (St.-Petersburg
State University, Russia), her translator Vladimir Boykov, and content
expert Charles E. Wood (University of Florida) participate in the podcast about
the influence of polymorphisms in the bradykinin and renin-angiotensin systems
on hemodynamic responses to the diving reflex. What is the relevance of the
potential functional implications of the mutations of the genes ADBR2, ACE,
AGTR1, BDKRB2, and REN during transient hypoxia and how might this apply to
personalized medicine? Listen to the podcast @ http://ajpheart.podbean.com.
Liliya Yamaleyeva’s abstract
and Renoprotective Actions of (Pyr1)-Apelin-13 in Preeclampsia” was selected for oral
presentation at the Society for Reproductive Investigation’s 63rd Annual
Scientific Meeting. Yamaleyeva LM, Brosnihan KB, McGee C, Shi S, Varagic J,
Bader M, Dechend R, Shaltout
HA, “Hemodynamic and Renoprotective Actions of (Pyr1)-Apelein-13 in
Preeclampsia”, Society for Reproductive Investigation’s 63rd Annual Scientific Meeting, March
16-19, 2016, Montreal, Canada.
listen to a recent podcast where Dr.
Debra Diz interviews Dr. Marc
Reitman about his findings that the brain Bombesin receptor 3 may play a role
in blood pressure regulation. Dr. Amy Arnold, former IPP graduate
student, serves as the content expert for the podcast. You may listen
to the podcast here: http://ajpheart.podbean.com.
from AJP-Heart and Circulatory
ensure every AJP-Heart and Circ podcast is discoverable through multiple
channels. Not only do we link the podcast to the article, but we also post on
our Facebook page (AJPHeartandCirc) and Twitter feed (@ajpheartcirc), as well
as prominently feature the podcast and article on our journal homepage (http://ajpheart.physiology.org)
in addition to our podcast website (http://ajpheart.podbean.com).
As well, every AJP-Heart and Circ podcast is downloadable on iTunes."
Bryan Wilson has
been selected to receive the 2016 Mid-Atlantic PREP/IMSD Research Symposium
Distinguished PREP Alumni Award and has been invited to give a talk and receive
the award at the 4th Annual MAPRS meeting May 25th and 26th 2016 at Virginia
Commonwealth University, Richmond, VA
Bryan was also
selected by the local chapter of the American Heart Association to give a talk
in June for the 1st Annual AHA Emerging Leaders’ Summit in
Alexa Hendrick’s abstract
was selected for an oral presentation and poster session at the ASPET Annual
Meeting at Experimental Biology 2016, in San Diego, CA, April 2-6, 2016.
Alexa Hendricks and A’ja Duncan were accepted into the Future Leaders
Advancing Research in Endocrinology (FLARE) program, run by the Endocrine
Society. A workshop was held Feb 4-6 in Los Angeles with a two day
training session teaching participants the “business of research” and establishing
themselves as independent researchers. They will also have the opportunity to
interview and serve on one society governance committee.
A’ja Duncan’s abstract “Beneficial
Cardiovascular Effects of Muscadine Grape Extract in Normotensive Female Rats”
was selected for a poster session at the ASN Annual Meeting at EB 2016, in San
Diego CA, April 2-6, 2016. Abstract was selected for ASN Emerging Leaders
in Nutrition Science Poster Competition.
Bryan Wilson’s latest
publication titled, “Evidence for a Mitochondrial Angiotensin-(1-7) System in
the Kidney” was selected to be a part of the February 2016 APSselect
featured articles and was acknowledged with a certificate for
distinction in scholarship in the American Journal of Physiological-Renal
TanYa Gwathmy-Williams was awarded the AHA Council for Epidemiology
and Lifestyle Young Investigator Travel Award and the NIDDK – National Minority
Research Investigators Travel Award to attend the Southeast Regional Workshop
Nancy Pirro (20 years)
and Sarah Smith (30 years) received Service Awards for
their contribution to the Wake Forest Health Sciences over the many years!
Several members of the Hypertension Center presented their work
at the AHA High Blood Pressure
Research Scientific Sessions Meeting in
September of 2015. There were 12 abstracts presented with 3 oral presentations
by Bryan Wilson, Dr. Hossam Shaltout, and Dr. Liliya M. Yamaleyeva; 4
abstracts were selected to be presented at the AHA Scientific Sessions in
Mark Chappell, PhD has been
invited to the Gordon Research Conference Angiotensin 2016 Conference in
Tuscany, Italy in February 2016. The title of his presentation is
“Evidence for an Intracellular Angiotensin-(1-7) Axis”.
Mark Chappell, PhD has been
invited to the National AHA meeting in Orlando FL. He will be presenting
“Fetal Origins of Adult Cardiovascular Disease (Control#: 10309) in a
Cardiovascular Seminar entitled Early Childhood Influences on Adult
Cardiovascular Disease: Can We Intervene Successfully?” He will also present
“Update on Angiotensin Converting Enzyme 2-angiotensin (1-7)-MAS receptor axis:
fetal programming, sex differences and intracellular pathways (Control#: 1644)
in a Hybrid entitled Sex Differences in Hypertension”.
Gallagher and Ann Tallant were
featured in the September edition of Winston-Salem Magazine, along with some
other investigators who work with Wake Forest Innovations. The article is
focused on thier studies on angiotensin-(1-7) and stroke prevention in
women. Please follow the link to view the full article: http://www.journalnow.com/winstonsalemmonthly/game-changers/article_e7387cba-4c25-11e5-80dc-9b6fa543aee7.html
Hypertension Core Laboratory has changed names as well as moved its
location. Now called The
Biomarker Analytical Core, the
new address is Biotech Place: 575 N. Patterson Avenue, Suite 134 Winston
Salem, NC 27101. You may reach the lab by phone at 336-716-3553 or by fax
The annual Tanglewood Heart and Stroke Walk was held Saturday,
October 17th at Tanglewood Park. This year the amount raised for the
American Heart Association has totaled $459, 475 and still counting. Wake
Forest Baptist Medical Center has raised $62,256 to date, with the Hypertension
and Tallant Girl Scout Teams raising $2,707 to date. GREAT
Katherine L. Cook, Ph.D. Assistant Professor in the
Comprehensive Cancer Center
Hypertension and Vascular Research Center, received a 2-year (01/2016-01/2018) "Living in Pink/Prevent Cancer
Partnership Award” from the Prevent Cancer Foundation titled "Prevention of
Obesity-induced Breast Cancer and Tamoxifen Drug Resistance." This project
investigates the impact of various obesity-inducing diets enriched in differing
fatty acids compositions (e.g. saturated vs. unsaturated vs. polyunsaturated fats)
on breast tumorigenesis and chemotherapy responsiveness. The studies are
focusing on how dietary fats may promote cellular stress pathway signaling to
favor cancer development. Moreover, we aim to develop a metabolomic profile
from mammary glands of mice on varying diets.
Shaltout, Ph.D., Assistant Professor in the Hypertension and Vascular Research
Center and the Department of Obstetrics and Gynecology was awarded a 4-year
(01/1/16 to 12/31/19) American
Heart Association Scientist Development Grant titled “Comprehensive Assessment of
Vascular and Autonomic Function in Children with Low Vitamin D” The goals of
this project are to determine the role of vitamin D deficiency in the autonomic
impairment seen in children with orthostatic intolerance and whether vitamin D
supplementation can improve the autonomic function in these children.
Dr. David Soto-Pantoja received NIH/NCI K22 grant September 1
titled, “Therapeutic targeting of CD47 regulates tumor cell bioenergetics and
mitophagy”. The objectives of this work is to find novel mechanisms to
reduce tumor growth, overcome the development of resistance to chemotherapy and
reduce metastasis of breast cancer which is responsible for over 40,000 deaths
every year in the U.S. Also many chemotherapeutic agents have harmful side
effects particularly in the cardiovascular system. Novel pathways that can be
used as targets to overcome cardiotoxicity and protect vascular tissue while
simultaneously sensitizing the tumor to chemotherapy will be studied in this project.
M. Yamaleyeva received
an R21 grant titled: “Longitudinal assessments of placental oxygenation and
perfusion using ultrasound and photoacoustics” by NICHD. This proof of concept
study will provide a validation of photoacoustic imaging for the assessments of
placental oxygenation/hypoxia during pregnancy and will offer an avenue for
future clinical application of this technology. A multidisciplinary team
includes: Dr. Aaron Mohs,
an Assistant Professor of Pharmaceutical Sciences at the University of Nebraska
Medical Center, Dr. Yao Sun,
a Research Associate at the Department of Radiology of WFSM. Professors K. Bridget Brosnihan, (General
Rose, and Robert Taylor,
(Department of Obstetrics and Gynecology) of WFSM will serve as an Internal
Advisors on this project. For more information on the Human Placental
Project that funded this research, please go to: NIH invests $46 million in
technologies to monitor placental health