Vascular Biology Laboratory

Aorta

Premenopausal females have a lower incidence of many cardiovascular diseases, including hypertension. Because this protection steeply declines after menopause, we know that estrogen is at least partially responsible for these beneficial effects. In the vasculature, estrogen alters the expression of a variety of genes including hormone receptors, growth factors, and extracellular matrix proteins and also directly promotes smooth muscle cell relaxation. There are two known estrogen receptor subtypes that mediate the genomic actions of the steroid; however, it is not known whether the newly discovered estrogen receptor GPR30 contributes to estrogen’s cardioprotective effects. Previous results from this laboratory show that in congenic mRen2 rats, a model of angiotensin II-dependent hypertension, females display only mild increases in blood pressure in comparison to males unless ovariectomized. This unique estrogen-sensitive model appropriately reflects the higher blood pressure seen in postmenopausal women.

This laboratory utilizes a unique angiotensin II-dependent, estrogen-sensitive, and salt-sensitive rodent model of hypertension to dissect the mechanisms by which GPR30 mediates its cardiovascular effects. We take an integrative approach by utilizing an in vitro cell culture system, an ex vivo isolated resistance vessel preparation, and in vivo analysis of the congenic mRen2 hypertensive animal to assess the acute and chronic interactions of GPR30 and the renin-angiotensin system.

 

Quick Reference

Hypertension and Vascular Research Center

Phone: 336-716-5819
FAX: 336-716-2456
Clinic Appointments:
336-716-2949
Hemodynamic Diagnostic Lab Scheduling
336-716-9423

Location
Hypertension & Vascular Research Center
Wake Forest School of Medicine, 6 Hanes
Medical Center Boulevard, Winston-Salem, NC
27157
Find A Doctor Ways to Give
Last Updated: 06-23-2014
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.