Liu, Tie Fu, PhD - Understanding molecular mechanism(s) involved in gene silencing and immunosuppression during severe systemic inflammation (SSI), generation of new therapeutic interventions or preventions to improve poor SSI outcomes. Experimental studies are focused on the epigenetic regulation and gene remodeling of proinflammatory cytokines during the initiation, adaptation and, especially, resolution of SSI; and on the interplay between the energy change and members of sirtuin family and NFk-B family in a THP-1 cell model and an animal model.
Loeser, Richard, MD - Lab: The cellular and molecular mechanisms that regulate cartilage destruction in osteoarthritis and the role of aging. Clinical: The genetics of osteoarthritis; exercise and weight loss interventions for osteoarthritis
McCall, Charles E., MD - The molecular events that control the inflammatory components of innate immunity
Rao, Anuradha, PhD
Seeds, Michael C., PhD - Inflammation and host defense in the lung; regulation and function of secretory phospholipases A2; differential regulation of granulocyte apoptosis
Tsang, Allen, PhD- 1) Infectious Diseases: Elucidate C. trachomatis-mediated MKK4 down regulation in promoting tumor metastasis, using molecular assays, high-throughput proteomics and imaging technologies to identify signaling networks in the developmental cycle of Chlamydia infections. 2) Redox Biology: Mapping phosphorylation events associated with oxidative and radiation damage response; the effect of these events on cell cycle regulation; Clinical proteomics to identify potential targets in cancer therapy.
Yammani, Raghunatha, PhD- S100 proteins and cartilage physiology; Role of S100A4 in the development of osteoarthritis
Molecular Medicine Associate Faculty
Andersson, Karl-Erik, MD, PhD
Atala, Anthony, MD - Tissue Engineering, Reconstructive Urology, Stem cells
Brosnihan, K. Bridget, PhD, MS – Role of Ang 1-7 in normal pregnancy and preeclampsia
Chilton, Ski, PhD - The role of fatty acid metabolism in human diseases; function of botanical lipids as dietary supplements
Codina, Juan, PhD
DuBose, Thomas, MD - Regulation of renal transporters; Potassium balance; Molecular description of transporters responsible for urinary acidification; Expression and molecular regulation of non-gastric H+,K+-ATPases in kidney and distal colon, aldosterone deficiency and excess; Renal tubular acidosis; Clinical acid-base and electrolyte disorders
Hantgan, Roy, PhD - Integrin structure and function; molecular and cellular mechanisms of blood coagulation and fibrinolysis; conformation of proteins in solution
High, Kevin P., MD - Translational research of age-related changes in immune function, termed immune senescence
Hite, R. Duncan, MD - Critical care with specific emphasis in acute respiratory failure, mechanical ventilation, ARDS, shock, sepsis and pneumonia; surfactant function and injury in ARDS
McPhail, Linda, PhD - The molecular mechanisms involved in the activation of the leukocyte NADPH oxidase
Mishra, Nilamadhab, MD - Epigenetics, chromatin remodeling, transcriptional regulation, gene expression and identifying therapeutic targets by proteomics in lupus
Swords, W. Edward, PhD - Understanding how commensal bacteria and the host develop and maintain a mutually beneficial, symbiotic relationship; Cellular Microbiology of Airway Infections
Yoza, Barbara, PhD - Deciphering the molecular events associated with the onset and progression of septic shock, particularly as it relates to the synthesis inflammatory mediators from cells of the blood