Furdui, Cristina, PhD - The Furdui laboratory is interested in applying chemical, computational and advanced systems biology methodologies to investigate the molecular mechanisms linking redox balance to disease development and treatment. Specifically, the laboratory focuses on: 1] Development of Chemical Approaches for the Quantitative Analysis of Protein Thiol Oxidative Modifications; 2] The Implications of Akt2 Redox-regulation in Radiation-associated Diabetes and Muscle Function in Aging, and 3] Head and Neck Cancer Prevention, Treatment and Improvement of Quality of Life. Chemical and analytical methods developed in the context of these projects are further applied to a number of collaborative studies investigating redox effects in aging, kidney disease, inflammation, sepsis and others. Lab Page
Liu, Tie Fu, PhD - Understanding molecular mechanism(s) involved in gene silencing and immunosuppression during severe systemic inflammation (SSI), generation of new therapeutic interventions or preventions to improve poor SSI outcomes. Experimental studies are focused on the epigenetic regulation and gene remodeling of proinflammatory cytokines during the initiation, adaptation and, especially, resolution of SSI; and on the interplay between the energy change and members of sirtuin family and NFk-B family in a THP-1 cell model and an animal model.
St. Clair, Richard W., PhD (Emeritus) - Understanding the pathogenesis of atherosclerosis, with an emphasis on the cell biology and biochemistry of the progression and regression of atherosclerotic lesions, and the mechanisms by which plasma lipoproteins and other risk factors alter the development of this disease.
Tsang, Allen, PhD- 1) Infectious Diseases: Elucidate C. trachomatis-mediated MKK4 down regulation in promoting tumor metastasis, using molecular assays, high-throughput proteomics and imaging technologies to identify signaling networks in the developmental cycle of Chlamydia infections. 2) Redox Biology: Mapping phosphorylation events associated with oxidative and radiation damage response; the effect of these events on cell cycle regulation; Clinical proteomics to identify potential targets in cancer therapy.
Yammani, Raghunatha, PhD- S100 proteins and cartilage physiology; Role of S100A4 in the development of osteoarthritis
Zhu, Xuewei, PhD-
Research Interests: Lipid metabolism and immune cell fundtion and their roles in the pathogenesis of chronic inflammatory diseases. Lab Page
Molecular Medicine Associate Faculty
Andersson, Karl-Erik, MD, PhD
Antinozzi, Peter, PhD - Regulation of transcription networks common to both diabetes and cancer; The role of inflammatory response toward the progression of diabetes and neurodegenerative diseases; Methods to preserve pancreatic islet function and mass.
Atala, Anthony, MD - Tissue Engineering, Reconstructive Urology, Stem cells
Brosnihan, K. Bridget, PhD, MS – Role of Ang 1-7 in normal pregnancy and preeclampsia
Chilton, Ski, PhD - The role of fatty acid metabolism in human diseases; function of botanical lipids as dietary supplements
DuBose, Thomas, MD (Emeritus) - Regulation of renal transporters; Potassium balance; Molecular description of transporters responsible for urinary acidification; Expression and molecular regulation of non-gastric H+,K+-ATPases in kidney and distal colon, aldosterone deficiency and excess; Renal tubular acidosis; Clinical acid-base and electrolyte disorders
Hantgan, Roy, PhD (Emeritus) - Integrin structure and function; molecular and cellular mechanisms of blood coagulation and fibrinolysis; conformation of proteins in solution
High, Kevin P., MD - Translational research of age-related changes in immune function, termed immune senescence
Kavanagh, Kylie, DVM, MS, MPH - Research interests include general investigations of metabolic syndrome and its determinants using non-human primate models. Specific areas of focus include 1) insulin resistance and diabetes development 2) aging and cellular stress resistance/chaperone proteins 3) nutritional effects of varying fat and carbohydrate type on metabolism 3) intestinal motility and integrity as a determinant of health and function in aging 4) chronic effects of radiation exposure on body composition and metabolic disease 5) sarcopenia and physical function 6) gut-brain interactions in Alzheimer’s disease risk.
McPhail, Linda, PhD (Emeritus) - The molecular mechanisms involved in the activation of the leukocyte NADPH oxidase
Mishra, Nilamadhab, MD - Epigenetics, chromatin remodeling, transcriptional regulation, gene expression and identifying therapeutic targets by proteomics in lupus
Petrovic, Snezana, MD
Swords, W. Edward, PhD - Understanding how commensal bacteria and the host develop and maintain a mutually beneficial, symbiotic relationship; Cellular Microbiology of Airway Infections
Vachharajani, Vidula, MD
Yoza, Barbara, PhD - Deciphering the molecular events associated with the onset and progression of septic shock, particularly as it relates to the synthesis inflammatory mediators from cells of the blood
Molecular Medicine Adjunct Faculty
Connelly, Margery A., PhD