Molecular Medicine Faculty Research Interests

Section of Molecular Medicine Researchers Cristina Furdui and Revati Wani at Mass Spectrometer

       Molecular Medicine Faculty

Furdui, Cristina, PhD 
Research Interests: The Furdui laboratory is interested in applying chemical, computational and advanced systems biology methodologies to investigate the molecular mechanisms linking redox balance to disease development and treatment. Specifically, the laboratory focuses on: 1] Development of Chemical Approaches for the Quantitative Analysis of Protein Thiol Oxidative Modifications; 2] The Implications of Akt2 Redox-regulation in Radiation-associated Diabetes and Muscle Function in Aging, and 3] Head and Neck Cancer Prevention, Treatment and Improvement of Quality of Life. Chemical and analytical methods developed in the context of these projects are further applied to a number of collaborative studies investigating redox effects in aging, kidney disease, inflammation, sepsis and others. Lab Page

Liu, Mingxia, PhD
Research Interests:  Research Interest: Metabolism of lipids (TG, cholesterol and sphingolipids) and lipoproteins (HDL and VLDL); metabolic functions of sphingosine-1-phosphate and its carrier apoM in inflammatory diseases (atherosclerosis and sepsis); nicotine consumption in energy metabolism.

Liu, Tie Fu, MD, PhD 

Research Interests: Understanding molecular mechanism(s) involved in gene silencing and immunosuppression during severe systemic inflammation (SSI), generation of new therapeutic interventions or preventions to improve poor SSI outcomes.  Experimental studies are focused on the epigenetic regulation and gene remodeling of proinflammatory cytokines during the initiation, adaptation and, especially, resolution of SSI; and on the interplay between the energy change and members of sirtuin family and NFk-B family in a THP-1 cell model and an animal model.

McCall, Charles E., MD 
Research Interests: Molecular signaling pathways that direct acute inflammation from sepsis; nutrient balance of mitochondrial function; bioenergy shifts during mouse and human sepsis; sepsis epigenetic reprogramming; molecular therapeutic targets in acute inflammation; balancing glycolysis with fatty acid metabolism in inflammation; redox control of  sirtuins; Sirtuin family interactions; RELB NFkB factor in sepsis; immunometabolism.

Parks, John S., PhD 
Teaching Interests: Lipoprotein Metabolism and Structure, Lipoprotein Modifying Enzymes.
Research Interests: High Density Lipoprotein (HDL) Formation and Catabolism, Molecular Mechanisms by which Lecithin:Colesterol Acyltransferase (LCAT) Prevents Atheroschlerosis, Molecular Mechanisms by which Botanical Oils and Fish Oil Impact Atheroscherosis and Inflammation. Lab Page

Rudel, Lawrence, PhD  
Teaching Interests: Disturbances in Plasma Lipoprotein Metabolism, Cholesterol Biosynthesis and Metabolism, Atheroschlerosis and Nutrition, Pathophysiology of Cholesterol and Bile Acids.
Research Interests: Nutrition in Atherosclerosis, Dietary Fatty Acids in Cardiovascular Disease, Hepatic Cholesterol Metabolism and Gene Regulation, Primate Liver Perfusion, Plasma Lipoprotein Metabolism, Cholesterol Ester Formation. Lab Page 

Seeds, Michael C., PhD 
Research Interests: Inflammation and host defense in the lung; regulation and function of secretory phospholipases A2; differential regulation of granulocyte apoptosis

Solberg Woods, Leah, PhD
Research Interests: Genetics of type 2 diabetes and obesity using outbred rat models. My laboratory is interested in identifying genes involved in type 2 diabetes (T2D) using rat models. T2D is a growing health problem with 347 million people affected worldwide. Prevalence in the United States is expected to more than double by 2050.  We are using a genetic rat model, outbred heterogeneous stock (HS) rats, to identify relatively small chromosomal regions that play a role in diabetes related phenotypes. HS rats are outbred from eight inbred rat strains such that the chromosomal make-up of the progeny is a mosaic of the founding inbred strains. This enables the mapping of chromosomal loci to only 2-4 Megabases, significantly decreasing the number of possible candidate genes within each region.  Once genetic regions are identified, we use expression and sequence analysis to identify underlying causal genes.

St. Clair, Richard W., PhD (Emeritus) - Understanding the pathogenesis of atherosclerosis, with an emphasis on the cell biology and biochemistry of the progression and regression of atherosclerotic lesions, and the mechanisms by which plasma lipoproteins and other risk factors alter the development of this disease.

Tsang, Allen, PhD 
Research Interests: My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. My long-term goal is to design and develop interventional and therapeutic strategies to prevent or treat chlamydial infections and chlamydial associated diseases (e.g., cancer, lung infections, heart disease and reactive arthritis). In particular, in recent years, we began to investigate the mechanisms by which Chlamydia trachomatis mediates tumor development and metastasis and identified a critical role of EGFR (Epidermal Growth Factor Receptor) in this process. A provisional patent “Methods and Compositions for Treatment of Chlamydial Infection and Related Diseases” was filed in 2013 by Wake Forest Innovations based on the invention disclosure 14-30WF “Target Epidermal Growth Factor Receptor (EGFR) in Chlamydia Infections and Chlamydia-associated Diseases”.  Projects 

Yammani, Raghunatha, PhD
Research Interests: S100 proteins and cartilage physiology; Role of S100A4 in the development of osteoarthritis

Zhu, Xuewei, PhD
Research Interests: Lipid metabolism and immune cell fundtion and their roles in the pathogenesis of chronic inflammatory diseases. Lab Page

Molecular Medicine Joint Appointment Faculty

Groban, Leanne, MD - Professor of Cardiothoracic Anesthesiology. Research interests- aging, cardiac function, fitness/physical, trangenics, women's health issues.

Hoth, James Jason, MD, PhD - Associate Professor of General Surgery. Research interests - critical/intensive medicine, drugs/therapeutic agents pharm, education/training. 

Kavanagh, Kylie, DVM, MS, MPH -  Assistant Professor, Pathology-Comparative Medicine. Research interests include general investigations of metabolic syndrome and its determinants using non-human primate models. Specific areas of focus include 1) insulin resistance and diabetes development 2) aging and cellular stress resistance/chaperone proteins 3) nutritional effects of varying fat and carbohydrate type on metabolism 3) intestinal motility and integrity as a determinant of health and function in aging 4) chronic effects of radiation exposure on body composition and metabolic disease 5) sarcopenia and physical function 6) gut-brain interactions in Alzheimer’s disease risk. 

Donald A. McClain, MD, PhD - Professor of Internal Medicine-Section on Endocrinology and Metabolism; Director, Center on Diabetes, Obesity and Metabolism - Research Interests: Structure and function of the insulin receptor; Metabolic signaling by the hexosamine biosynthesis pathway mediated by protein O-linked glycosylation; Prevalence and mechanism of diabetes in hereditary hemochromatosis; Effects of dietary iron on diabetes risk; Hypoxia and metabolism.

Vachharajani, Vidula, MD- Associate Professor of Critical Care. Research interests - critical/intensive care medicine, immunology/allergy/inflammation, infectious disease, metabolism, obesity.

Wang, Hao, MD, PhD - Assistant Professor of Anesthesiology. Research interest- Aging, estrogen, GPR30, skeletal muscle, cardiac function. Research interests include the roles of the novel estrogen receptor, GPR30, in the maintenance of both cardiac and skeletal muscle structure and function during aging.

Yoza, Barbara, PhD- Assistant Professor, General Surgery. Research Interests-  Deciphering the molecular events associated with the onset and progression of septic shock, particularly as it relates to the synthesis inflammatory mediators from cells of the blood

Molecular Medicine Adjunct Faculty

Connelly, Margery A., PhD

Om Tejendra Makwana, PhD - Adjunct Assistant Professor







  

    

  


   
  

Quick Reference

Section of Molecular Medicine
North Tower
3rd Floor

Office 336-713-4259

Kay Collare
Administrative Assistant

336-713-4259

kcollare@wakehealth.edu

Kay Collare
Section of Molecular Medicine
Wake Forest School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157

 

Find A Doctor Ways to Give
Last Updated: 09-29-2016
Comprehensive Cancer Centers National Designation is RenewedMagnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

© Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157. All Rights Reserved.