Molecular Medicine Faculty Research Interests

Section of Molecular Medicine Researchers Cristina Furdui and Revati Wani at Mass Spectrometer

       Molecular Medicine Faculty

Brown, Candice M, PhD - Regulation of the brain's innate immune response by endogenous estrogens during acute and chronic inflammation

Furdui, Cristina, PhD - The Furdui laboratory is interested in applying chemical, computational and advanced systems biology methodologies to investigate the molecular mechanisms linking redox balance to disease development and treatment. Specifically, the laboratory focuses on: 1] Development of Chemical Approaches for the Quantitative Analysis of Protein Thiol Oxidative Modifications; 2] The Implications of Akt2 Redox-regulation in Radiation-associated Diabetes and Muscle Function in Aging, and 3] Head and Neck Cancer Prevention, Treatment and Improvement of Quality of Life. Chemical and analytical methods developed in the context of these projects are further applied to a number of collaborative studies investigating redox effects in aging, kidney disease, inflammation, sepsis and others. Lab Page

Liu, Tie Fu, PhD 
- Understanding molecular mechanism(s) involved in gene silencing and immunosuppression during severe systemic inflammation (SSI), generation of new therapeutic interventions or preventions to improve poor SSI outcomes.  Experimental studies are focused on the epigenetic regulation and gene remodeling of proinflammatory cytokines during the initiation, adaptation and, especially, resolution of SSI; and on the interplay between the energy change and members of sirtuin family and NFk-B family in a THP-1 cell model and an animal model.

Loeser, Richard, MD - Lab: The cellular and molecular mechanisms that regulate cartilage destruction in osteoarthritis and the role of aging. Clinical: The genetics of osteoarthritis; exercise and weight loss interventions for osteoarthritis

McCall, Charles E., MD - The molecular events that control the inflammatory components of innate immunity

Parks, John S., PhD -
Teaching Interests: Lipoprotein Metabolism and Structure, Lipoprotein Modifying Enzymes.
Research Interests: High Density Lipoprotein (HDL) Formation and Catabolism, Molecular Mechanisms by which Lecithin:Colesterol Acyltransferase (LCAT) Prevents Atheroschlerosis, Molecular Mechanisms by which Botanical Oils and Fish Oil Impact Atheroscherosis and Inflammation. Lab Page

Rudel, Lawrence, PhD
Teaching Interests: Disturbances in Plasma Lipoprotein Metabolism, Cholesterol Biosynthesis and Metabolism, Atheroschlerosis and Nutrition, Pathophysiology of Cholesterol and Bile Acids.
Research Interests: Nutrition in Atherosclerosis, Dietary Fatty Acids in Cardiovascular Disease, Hepatic Cholesterol Metabolism and Gene Regulation, Primate Liver Perfusion, Plasma Lipoprotein Metabolism, Cholesterol Ester Formation. Lab Page 

Seeds, Michael C., PhD - Inflammation and host defense in the lung; regulation and function of secretory phospholipases A2; differential regulation of granulocyte apoptosis

Shelness, Gregory, PhD -
Teaching Interests: Molecular Biology, Pathobiology of Atherosclerosis, Pathologic Biochemistry, Disturbances in Lipoprotein Metabolism.
Research Interests: Secretory Protein Biogenesis, Lipoprotein Metabolism. Lab Page

Sorci-Thomas, Mary, PhD -
Teaching Interests: Molecular Genetics,; Pathobiology of Atherosclerosis; Lipoprotein Cholesterol.
Research Interests: Mechanisms Relating Inflammation and Atherosclerosis; Association of Dietary Cholesterol and the Onset of Autoimmunity; Structure and Function of Apolipoproteins; High Density Lipoprotein (HDL) Formation and Metabolism; Activation of Lecithin:Cholesterol Acyltransferase by Apolipoprotein (Apo) A-I. Lab Page
 
St. Clair, Richard W., PhD (Emeritus) - Understanding the pathogenesis of atherosclerosis, with an emphasis on the cell biology and biochemistry of the progression and regression of atherosclerotic lesions, and the mechanisms by which plasma lipoproteins and other risk factors alter the development of this disease.

Tsang, Allen, PhD1) Infectious Diseases: Elucidate C. trachomatis-mediated MKK4 down regulation in promoting tumor metastasis, using molecular assays, high-throughput proteomics and imaging technologies to identify signaling networks in the developmental cycle of Chlamydia infections. 2) Redox Biology: Mapping phosphorylation events associated with oxidative and radiation damage response; the effect of these events on cell cycle regulation; Clinical proteomics to identify potential targets in cancer therapy.

Yammani, Raghunatha, PhD- S100 proteins and cartilage physiology; Role of S100A4 in the development of osteoarthritis

Zhu, Xuewei, PhD-
Research Interests: Lipid metabolism and immune cell fundtion and their roles in the pathogenesis of chronic inflammatory diseases. Lab Page

Molecular Medicine Associate Faculty

Andersson, Karl-Erik, MD, PhD

Antinozzi, Peter, PhD - Regulation of transcription networks common to both diabetes and cancer; The role of inflammatory response toward the progression of diabetes and neurodegenerative diseases; Methods to preserve pancreatic islet function and mass. 

Atala, Anthony, MD - Tissue Engineering, Reconstructive Urology, Stem cells

Brosnihan, K. Bridget, PhD, MS – Role of Ang 1-7 in normal pregnancy and preeclampsia

Chilton, Ski, PhD  - The role of fatty acid metabolism in human diseases; function of botanical lipids as   dietary supplements

DuBose, Thomas, MD (Emeritus) - Regulation of renal transporters; Potassium balance; Molecular description of transporters responsible for urinary acidification; Expression and molecular regulation of non-gastric H+,K+-ATPases in kidney and distal colon, aldosterone deficiency and excess; Renal tubular acidosis; Clinical acid-base and electrolyte disorders 

Hantgan, Roy, PhD (Emeritus) - Integrin structure and function; molecular and cellular mechanisms of blood coagulation and fibrinolysis; conformation of proteins in solution

High, Kevin P., MD - Translational research of age-related changes in immune function, termed immune senescence 

Kavanagh, Kylie, DVM, MS, MPH - Research interests include general investigations of metabolic syndrome and its determinants using non-human primate models. Specific areas of focus include 1) insulin resistance and diabetes development 2) aging and cellular stress resistance/chaperone proteins 3) nutritional effects of varying fat and carbohydrate type on metabolism 3) intestinal motility and integrity as a determinant of health and function in aging 4) chronic effects of radiation exposure on body composition and metabolic disease 5) sarcopenia and physical function 6) gut-brain interactions in Alzheimer’s disease risk.

McPhail, Linda, PhD (Emeritus) - The molecular mechanisms involved in the activation of the leukocyte NADPH oxidase

Mishra, Nilamadhab, MD - Epigenetics, chromatin remodeling, transcriptional regulation, gene expression and identifying therapeutic targets by proteomics in lupus

Petrovic, Snezana, MD

Swords, W. Edward, PhD - Understanding how commensal bacteria and the host develop and maintain a mutually beneficial, symbiotic relationship; Cellular Microbiology of Airway Infections

Vachharajani, Vidula, MD

Yoza, Barbara, PhD  - Deciphering the molecular events associated with the onset and progression of septic shock, particularly as it relates to the synthesis inflammatory mediators from cells of the blood

Molecular Medicine Adjunct Faculty

 Connelly, Margery A., PhD

 







  

    

  


   
  

Quick Reference

Section of Molecular Medicine
North Tower
3rd Floor

Office 336-713-4259

Kay Collare
Administrative Assistant

336-713-4259

kcollare@wakehealth.edu

Kay Collare
Section of Molecular Medicine
Wake Forest School of Medicine
Medical Center Boulevard
Winston-Salem, NC 27157

 

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