Gizem Keceli, PhD
My projects include investigating chemical strategies to detect sulfenic acid formation in complex biological systems, and studying the effects of redox-related thiol modifications on the structure of Akt2 using biochemical procedures and mass spectrometry techniques.
MMTS Graduate Student
My research focuses on the structural and functional consequences of Akt2 oxidation and their relation to reactive oxygen species associated diseases such as cancer and diabetes.
Hanzhi Wu, PhD
My research focuses on applications of mass spectrometry to investigate regulation of signaling, metabolism and epigenetics in a broad range of diseases.
Graduate student in the MMTS Ph.D. graduate program.
My project focuses on understanding the underlying mechanisms associated with resistance to radiation and drug targeted therapies phenotypes in HNSCC cells to identify new targets for inhibition, to overcome resistance to current therapies and to identify clinical biomarkers of response to therapies.
My current research interests are twofold. One is to define radiation response signatures in a matched model of radiation resistance for HNSCC and investigate the molecular mechanisms that lead to resistance to radiation. The other is to determine the role of EGFR signaling in the development of Chlamydia trachomatis and the relationship between chlamydial infection and cancer (head and neck and breast cancer).