Julie Reisz Haines, PhD
My research focuses on investigating the formation and reactivity of oxidized cysteine residues along with developing methods for their detection using mass spectrometry. In targeted studies, we are working to understand the structural mechanisms underlying peroxiredoxin hyperoxidation (inactivation) and repair, and in broader studies, we use mass spectrometry to explore the cellular impacts of cysteine oxidation and how oxidation targets change during disease progression.
Graduate student in the MMTS Ph.D. graduate program.
My project focuses on understanding the underlying mechanisms associated with resistance to radiation and drug targeted therapies phenotypes in HNSCC cells to identify new targets for inhibition, to overcome resistance to current therapies and to identify clinical biomarkers of response to therapies.
Nelmi Devarie-Baez, PhD
Translational Radiation Oncology Fellow
My current research interest is to study how radiation-induced reactive oxygen species impact the thiol-proteome and alter mechanism of radiation response. Other areas of research interest includes 1) synthetic methodology, 2) medicinal chemistry and 3) chemical strategies to analyze thiol-redox proteome by mass spectrometry.
Elsa Silva Lopez
IRAC-PRIME Postdoctoral Fellow
My research interest involves the study on the effect of oxidation in the structure and functionality of Akt2 and how this can be related to diseases such as aging and radiation-associated diabetes.
My current research interests are twofold. One is to define radiation response signatures in a matched model of radiation resistance for HNSCC and investigate the molecular mechanisms that lead to resistance to radiation. The other is to determine the role of EGFR signaling in the development of Chlamydia trachomatis and the relationship between chlamydial infection and cancer (head and neck and breast cancer).