Chemical Probes

Development of Chemical Approaches for the Quantitative Analysis of Protein Thiol Oxidative Modifications

This project is the product of collaboration with colleagues Drs. Leslie Poole (Department of Biochemistry) and S. Bruce King (Department of Chemistry) at Wake Forest. Over the past 10 years, our groups have developed chemical probes for investigating and quantifying oxidative modifications of protein cysteine thiols focusing in particular on sulfenic -SOH species (shown here).


The probes cover a broad range of reactivity profiles to fit various applications and are compatible with analysis by mass spectrometry, Western blotting and imaging [e.g., application of the BP1 reagent in imaging of tumor samples is shown under Head and Neck Cancer Project].

 

 

Quick Reference

Cristina Furdui

Office: 336-716-2697
Fax: 336-716-1214
Lab: 336-713-4073

cfurdui@wakehealth.edu

NRC 226
Medical Center Blvd.
Winston-Salem, NC 27157
Find A Doctor Ways to Give
Last Updated: 05-30-2014
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.