Neonatology Research

Eight neonatology faculty are involved in research programs covering basic, translational and clinical research.  Basic research includes studies in vascular physiology and intestinal development.  Translational research includes animal models of bowel function and growth after bowel resection. Current clinical studies are described below:   

 O'Shea T Michael D
T. Michael O'Shea, MD, MPH 

Preterm Erythropoietin Neuroprotection Trial (PENUT
Principal Investigator
: T. Michael O'Shea, MD, MPH 
Coordinators: Warden
Study Type: Randomized multicenter trial
Purpose: To test the hypothesis that early high dose erythropoietin decreases the risk of brain damage in extremely preterm infants.   

Neonatal Neurobehavioral: Does it Predict Developmental Outcome at 2 Years of Age 
Principal Investigator
: T. Michael O'Shea, MD, MPH 
Coordinators: Warden
Study Type: multi-centered observational
Purpose: To test the hypothesis that an abnormal neurobehavioral examination at 36 weeks post-menstrual age is predictive of adverse neurodevelopmental outcome at 2 years of age. 

Gene Targets for IVH       
Principal Investigator: T. Michael O'Shea, MD, MPH 
Funding: NIH
Study Type: Observational; multi-centered; NIH
Purpose: To assess the relative contribution of genetic factors to Grade 3-4 IVH in preterm neonates 500-1250 grams (control matched--ie, normal CUS, gender, BW, and site).

ELGAN-2 (began October 2011)  
Principal Investigator: T. Michael O'Shea, MD, MPH 
Funding: NIH
Study Type: Observational; multi-centered; NIH
Purpose

Pediatric Trials Network 
Principal Investigator: T. Michael O'Shea, MD, MPH 
Funding: NIH
Study Type: Observational; multi-centered; NIH 

Downey Laura Corbin
L. Corbin Downey, MD, MPH 

Antibiotic Safety in Infants with Complicated Intra-Abdominal Infections (SCAMP)
Principle Investigator
: L. Corbin Downey, MD, MPH 
Coordinator: Ludwig 
Study Type: Randomized, multi-center, open-label, safety study 
Purpose: Assess the safety and efficacy of various antibiotic regiments in infants with complicated intra-abdominal infections. 

Preterm Erythropoietin Neuroprotection Trial (PENUT)
Sub-Principle Investigator
:  L. Corbin Downey, MD, MPH 
Coordinator:Warden 
Study Type: Randomized, multi-center trial
Purpose: To test the hypothesis that early high dose erythropoietin decreases the risk of brain damage in extremely preterm infants.

 Helderman Jennifer B
Jennifer B. Helderman, MD, MS 

TOLSurf 
Principal Investigator:
Jennifer B. Helderman, MD, MS 
Coordinator: Warden
Study Type: Randomized trial; multi-centered
Purpose: This is the randomized trial of late surfactant (after 7 days of age) in very preterm infants with ventilator dependency.

  
Washburn Lisa K
Lisa K. Washburn, MD

PEPC-2 (Prenatal Events - Postnatal Consequences)                        
Prinicipal Investigator
: Lisa K. Washburn, MD
Coordinator: Scott
Funding: NIH
Study Type: Observational Cohort
Purpose: This is a study of cardiovascular metabolic outcomes of 19 year old children 



Yang Qing
Qing Yang, MD, PhD 


Early Supplementation of Enteral Lipids including fish oil in Infants with
Ostomies
Principal Investigator
: Qing Yang, MD, PhD
Funding: The Gerber Foundation; Wake Forest Center for Botanical Lipids
Study Type: Randomized trial
Purpose: This is the randomized trial of fish oil/microlipid supplements for infants with ostomy  

 

 

 

 

 

 

 

 

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