Neonatology Research

Several neonatology faculty are involved in research programs covering basic, translational and clinical research.  Basic research includes studies in vascular physiology and intestinal development.  Translational research includes animal models of bowel function and growth after bowel resection. Current clinical studies are described below:   

Downey Laura Corbin
L. Corbin Downey, MD, MPH 

Antibiotic Safety in Infants with Complicated Intra-Abdominal Infections (SCAMP)
Principle Investigator: L. Corbin Downey, MD, MPH 
Coordinator: Peters 
Study Type: Randomized, multi-center, open-label, safety study 
Purpose: Assess the safety and efficacy of various antibiotic regiments in infants with complicated intra-abdominal infections. 

Preterm Erythropoietin Neuroprotection Trial (PENUT)
Principle Investigator:  L. Corbin Downey, MD, MPH 
Coordinator: Lanier 
Study Type: Randomized, multi-center trial 
Purpose: To test the hypothesis that early high dose erythropoietin decreases the risk of brain damage in extremely preterm infants.

Helderman Jennifer B
Jennifer B. Helderman, MD, MS

Neonatal Neurobehavioral: Does it Predict Developmental Outcome at 2 Years of Age (NOVI)
Principal Investigator: Jennifer B. Helderman, MD, MS
Co-Investigator:  Michael O'Shea, MD, MPH 

Coordinator: Peters
Study Type: multi-centered observational
Purpose: To test the hypothesis that an abnormal neurobehavioral examination at 36 weeks post-menstrual age is predictive of adverse  outcome at 2 years of age. 

Principal Investigator:
 Jennifer B. Helderman, MD, MS 
Coordinator: Lanier
Study Type: Randomized trial; multi-centered 
Purpose: This is the randomized trial of late surfactant (after 7 days of age) in very preterm infants with ventilator dependency.

Washburn Lisa K
Lisa K. Washburn, MD

PEPC-2 (Prenatal Events - Postnatal Consequences)                        
Prinicipal Investigator
: Lisa K. Washburn, MD
Coordinator: Scott
Funding: NIH
Study Type: Observational Cohort
Purpose: This is a study of cardiovascular metabolic outcomes of 19 year old children 

ELGAN-2  (Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain Disorders (Extremely Low Gestatinoal Age Newborns-2) -(began October 2011) 
Principal Investigator: Lisa K. Washburn, MD
Co-Investigator: T. Michael O'Shea, MD, MPH 
Coordinator: Peters
Funding: NIH
Study Type: Observational; multi-centered; NIH 
Purpose: To evaluate the relationship of perinatal inflammation and cognitive impairment in extremely preterm children. 

Pediatric Trials Network 
Principal Investigator: T. Michael O'Shea, MD, MPH 
Funding: NIH
Study Type: Observational; multi-centered; NIH 









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