Clincal Trials and Grants

 

Nephrology Faculty Grants

The Nephrology faculty is actively involved in several clinical trails.  The term clinical trialmay be applied to any form of planned experiment which involves patients and is designed to elucidate the most appropriate treatment of future patients with a given medical condition. 

Many thousands of people take part in medical trials every year. When a qualified candidate chooses to participate in a clinical study, the research often affects thousands of others who benefit from the trial's results.

Below is a list of recently completed and current grants in which the Nephrology faculty is involved.

 

Barry Freedman, MD

NIH (1 U01 DK57298): Family investigation in nephropathy and diabetes (FIND) Genome Wide Association Study; Barry Freedman, PI.; Total Project Period: 5/1/09-4/30/11; Direct Costs: $65,000

NIH (RO1 DK070941): Genetic analysis of African American hypertensive end-stage renal disease;  Barry Freedman, PI; Total Project Period: 5/1/06-4/30/10; Direct Costs: $286,630  

NIH (RO1 DK071891): Subclinical CVD in African American type 2 diabetes; Barry Freedman, PI;  Total Project Period: 9/1/07-8/31/11; Direct Costs: $461,519

NIH (R01DK084149): Natural history of MYH-9-associated nephropathy; Barry Freedman, PI;  Michael Rocco, Co-I; Total Project Period: 7/1/09-6/30/13; Direct Costs: $478,605

COLLABORATIVE

NIH-DK (RO1 DK53591--competitive renewal): Mapping genes for NIDDM nephropathy in African Americans; Donald Bowden, PI, Barry Freedman, Co-I; Total Project Period: 8/01/05-5/31/10; Direct Costs: $345,311

NIH (DK56289):Identification of diabetes genes on human chromosome 20; Donald Bowden, PI;  Barry Freedman, Co-I ;Total Project Period: 9/15/05-7/31/10; Direct Costs: $232,304

NIH-NINDS (1R01 NS058700-01A1): Genetic epidemiology of cerebrovascular disease and  cognition in diabetes; Donald Bowden, PI, Barry Freedman, Co-I; Total Project Period:  4/1/08-3/31/13; Direct Costs: $444,389

NIH/NIAMS: Lupus nephritis and renal failure (LN/ESRD): A national consortium to explore the  genotypic basis for immune-mediated ESRD; Robert Kimberly, PI, Barry Freedman, Co-I; Total  Project Period: 9/30/09-9/29/11; Direct Costs: $140,132

NIH/NHLBI (HHSN268200900040C): Systolic blood pressure intervention trial (SPRINT); David  Reboussin, PI, Barry Freedman, Co-I; Total Project Period: 9/30/09-09/29/14; Direct Costs: $3,492,910

1R01KD090111-01: Mapping diabetic susceptibility by expression traits in African Americans;  Donald Bowden, PI, Barry Freedman, Co-I; Total Project Period: 12/1/10-11/30/15; Direct Costs:  $360,788

NIH (2 R01 DK066358): Genetics of African American type 2 diabetes; Donald Bowden, PI, Barry Freedman, Co-I ; Total Project Period: 12/01/09-11/30/14; Direct Costs: $486,855

NIH (1 R01 HL92301-01A2): Whole genome association analysis of the Diabetes Heart Study;  Donald Bowden, PI, Barry Freedman, Co-I; Total Project Period: 12/01/09-11/30/14; Direct Costs:  $499,362

NIH (DK87914): Genetic determinants of adiposity in African Americans; Maggie Ng, PI, Barry Freedman, Co-I; Total Project Period: 4/1/10-3/31/15; Direct Costs: $499,180

Pirouz Daeihagh, MD

HemaMetrics: A randomized prospective controlled trial of ultrafiltration modeling using a blood volume Monitoring device (Crit-Line) in hypervolemic intensive care unit patients with acute kidney injury Requiring renal replacement therapy using CRRT. Pirouz Daeihagh, PI, Michael Rocco, Co-I. Total  Project Period: 10/1/09-9/30/11; Direct Costs: $30,000

Shahriar Moossavi, MD

PEP -08-274-01-PC2:  Paricalcitol for Palliation in Advanced Prostate Cancer: A Phase II Trial;  Gary Schwartz, PI; Shahriar Moossavi, Co-I; Total Project Period: 8/31/08-8/31/10

Amber Reeves-Daniel, MD

Southern Easter Kidney Council Network.  Registry of kidney donors outcomes of living kidney donation. Amber Reeves-Daniel, PI; Total Project Period: 1/1/09-12/31/10; Direct Costs: $15,000   

Michael Rocco , M.D

NIH-NIDDK (U01 DK066579): Frequent hemodialysis clinical trials: daily in-center clinical cite (Contracting Center, Renal Research Institute); Michael Rocco, PI at WFSM; Total Project Period: 9/30/03-9/31/11; Direct Costs: $97,554

NIH-NIDDK (U01 DK66480): Frequent hemodialysis clinical trials: nocturnal hemodialysis clinical coordinating center; Michael Rocco, PI; Total Project Period: 9/1/03-1/31/11; Direct Costs: $267,397

NIH (1 Ro1 DK074715-01A1):  Cognitive function in dialysis patients: ancillary study to the FHN  trial (Contracting Center, University of Iowa); Michael Rocco, PI at WFSM; Total Project Period: 1/1/08-7/31/11; Direct Costs: $16,000

HHSN268200900048C: NIH/NHLBI;Systolic Blood Pressure Intervention Trial (SPRINT); David Goff, PI, Michael Rocco, Co-I; Amret Hawfield, Co-I. Total Project Period: 8/31/09-8/30/14; Direct Costs: $1,497,947

WFSM Intramural Grant: Blood oxygenation level-dependent (BOLD) MRI for non-invasive determination of real blood flow and oxygenation. Michael Rocco, PI; Vardaman Buckalew, Co-I: Total Project Period: 10/1/09-9/30/10. Direct Costs: $41,314

Tushar Vachharajani, M.D.

Tyco Healthcare Group LP. A randomized,open-label comparison of the performance and longevity of a split-tip versus a symmetric tip hemodialysis catheter; Tushar Vachharajani, PI; Shahriar Moossavi, MD, Co-I . Total Project Period: 11/1/07-3/31/2011. Direct Costs: $864,230.16

 

 

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