Michael Tytell, PhD
Baylor College of Medicine, 1977
Injury to the nervous system by physical trauma or disease is devastating because neurons that die are difficult to replace. Loss of function following such an injury is not just a result of those neurons completely destroyed. It also reflects the death of those temporarily exposed to abnormal conditions, like insufficient oxygen supply. We are studying the "stress protein response", which occurs in most cells, as a way to prevent damaged neurons from dying. The proteins that are part of this response, commonly referred to as heat shock proteins (Hsps), make all cells, including neurons, more resistant to damage.
Robinson MB, Tidwell JL, Gould T, Taylor AR, Newbern JM, Graves J, Tytell M, Milligan CE (2005) Extracellular heat shock protein 70: A critical component for motoneuron survival. J Neurosci 25: 9735-9745.
Tytell M (2005) Release of Heat Shock Proteins (Hsps) and the Effects of Extracellular Hsps on Neural Cells and Tissues. Int J Hyperthermia 21: 445-455.
Tidwell JL, Houenou LJ, Tytell M (2004) Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration. Cell Stress & Chaperones 9: 88-98.
Dean DO, Tytell M (2001) Hsp25 and -90 immunoreactivity in the normal rat eye. Invest Ophthalmol Vis Sci 42: 3031-3040.
Tytell M, Hooper PL (2001) Heat shock proteins: new keys to the development of cytoprotective therapies. Emerging Therapeutic Targets 5: 267-287.
Yu Q, Kent CR, Tytell M (2001) Retinal uptake of intravitreally injected Hsc/Hsp70 and its effect on susceptibility to light damage. Molec Vis 7: 48-56.
Guzhova I, Kislyakova K, Moskoliova O, Fridlanskaya I, Tytell M, Cheetham M, Margulis B (2001) In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914: 66-73.
Dean DO, Kent CR, and Tytell M (1999) Constitutive and inducible heat shock protein 70 immunoreactivity in the normal rat eye. Invest. Ophthalmol. Vis. Sci. 40:2952-2962.
Tytell M, Brown WR, Moody DM, and Challa VR (1998) Immunohistochemical assessment of constitutive and inducible heat-shock protein 70 and ubiquitin in human cerebellum and caudate nucleus. Molec. Chem. Neuropathol. 35:97-117.
Houenou LJ, Li L, Lei M, Kent CR, and Tytell M (1996) Exogenous heat shock cognate protein (hsp) 70 prevents axotomy-induced death of spinal sensory neurons. Cell Stress & Chaperones 1:161-166.
Tytell M, Barbe MF and Brown IR (1994) Induction of heat shock (stress) protein 70 and its mRNA in the normal and light-damaged rat retina after whole body hyperthermia. J. Neurosci. Res. 38:19-31.
Barbe MF, Tytell M, Gower DJ and Welch WJ (1988) Hyperthermia protects against light damage in the rat retina. Science, 241:1817-1820.