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HIRREM Research Overview

Welcome to the Wake Forest School of Medicine (WFSM) HIRREM research page

Who are we?

The HIRREM Research Team at WFSM is a multi-disciplinary, academic research group, based primarily in the Department of Neurology, pursuing scientific evaluation of the use of HIRREM, including effects and possible mechanisms.

What is HIRREM?

High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM®) is a novel, noninvasive, closed-loop, electroencephalic-based feedback technology to facilitate auto-calibration, and self-optimization of neural oscillations by using auditory tones to reflect dominant brain frequencies in near real time. HIRREM is not a medical device and is not intended to treat, cure, heal, or diagnose any disease, mental illness or symptom, and individual results and duration of effects may vary.

HIRREM Brain Graphic 500 pixels

What are we doing?

In 2011, our team launched a series of research projects to study the use of HIRREM in a clinical setting. The primary goals are to evaluate the potential benefits of HIRREM, identify which symptoms or conditions may benefit, and define the magnitude of any benefit using accepted scientific methods. With the help of many collaborators our secondary goal is to better understand the mechanism(s) of action for HIRREM.

Why are we doing this research?

Many symptoms associated with a variety of clinical conditions, including some with a neurological or neuropsychological basis, are in need of effective noninvasive, non-drug therapies. Preliminary research is promising, but additional investigation is needed to better define benefits, elucidate potential mechanisms, and establish utility. Our team has the knowledge and experience to carry out such research.

Overview of this webpage:

This webpage is intended to serve as a noncommercial resource regarding HIRREM and research being done at WFSM using this method. It includes sections providing both basic and detailed overviews of the HIRREM process. The WFSM HIRREM research webpage is geared towards medical personnel, potential collaborators, and other interested individuals seeking information about HIRREM, our ongoing research, presentations and publications, support for this work, and our team. To avoid interfering with the review process for future manuscripts reporting this research, the webpage only provides access or links to materials that have already been published or presented.



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Reduction of Post -Traumatic Stress Symptoms Associated with Non-invasive Neurotechnology

A closed-loop acoustic stimulation brainwave technology significantly reduced symptoms in people suffering from post-traumatic stress in a small pilot study conducted at Wake Forest Baptist Medical Center. The study is published in the April 19 online edition of the journal BMC Psychiatry. 

Reduction in Menopause-related Symptoms Associated with Non-invasive Neurotechnology

Nearly nine out of 10 premenopausal and postmenopausal women in the United States experience hot flashes, night sweats or other disturbances in mood and sleep. Unfortunately, there aren’t many safe and effective therapies available to manage these symptoms. 

New Study of Student Athletes with Persisting Concussion Symptoms Shows Improvement Following High-resolution, Relational, Resonance-based, Electroencephalic Mirroring (HIRREM)

A small pilot study of male and female high school- and college-age athletes found improvement in persisting post-concussion symptoms after undergoing High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM®).

Research Study Describes Potential New Method to Assess Stress

Stress. Life’s trauma, physical or non-physical, can cause a flight-or-fight, or a freeze, stress response. Most experience it. Some are crippled by it. So how can stress, the body’s responses to what life throws at us, be assessed?

Last Updated: 04-19-2017
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