Investigating Fitness Interventions in the Elderly (INFINITE)

Improving Muscle for Functional Independence (INFINITE)

 

Primary Aim: Determine the effects of adding moderate and intensive caloric restriction on the magnitude of improvement in maximal aerobic capacity (VO2max) and functional endurance (400 m walk time) in response to a standardized aerobic exercise training intervention.  

 

Primary hypothesis: The EX+High CR group will experience the greatest improvement in VO2max and 400m walk time, followed by the EX+Low CR group, and then the EX Only group.

 

Secondary Aim: Determine the effects of adding moderate and intensive caloric restriction on changes in specific CVD risk factors (inflammatory markers, blood lipids, blood pressure, and glucose tolerance) in response to a standardized aerobic exercise training intervention.

 

Hypothesis:  The EX+HIGH CR group will experience greater improvement in these CVD risk factors than the EX+LOW CR group, with no improvement observed in the EX Only group.

 

Tertiary Aim: Determine the effects of adding moderate and intensive caloric restriction to a standardized aerobic exercise training intervention on changes in inter-muscular, abdominal visceral and pericardial fat volumes, and determine whether improvements in aerobic function and CVD risk factors are related to the degree of total and regional fat loss.

 

Hypotheses:  The EX+HIGH fat loss group will experience greater declines in inter-muscular, abdominal visceral, and pericardial fat volumes than the EX+LOW fat loss group, with no declines observed in the EX only group.  Also, in the entire sample combined, improvements in VO2max and walking distance, and changes in CVD risk factors, will be related to declines in total and regional body fat.  

Last Updated: 08-10-2015
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