Integrative Biology Core
The Integrative Biology Core (IBC), in collaboration with other OAIC Cores, utilizes translational research to determine whether specific molecular, physiological, and histological mechanisms contribute to age-related increases in total and “ectopic” (abnormally located) fat, thereby resulting in loss of muscle mass and strength and subsequent decline in physical function, and that therapeutic modification of these factors can slow progression to disability.
This core also maintains the Pepper Center Integrated Aging Studies Databank and Repository (IASDR) which houses > 135,000 cryovials of serum or plasma collected from >3100 research participants enrolled in 29 different studies. The Repository also has >1260 DNA samples collected from research participants. All samples are collected from study participants enrolled in research protocols at Wake Forest University, Wake Forest University Health Sciences, or other collaborating institutions. More details are provided at the website below.
Wake Forest Pepper Center Specimen Repository (IASDR)
Barbara Nicklas, PhD, Leader
Osvaldo Delbono, Co-Leader
Karin Murphy, Laboratory Supervisor