Pilot / Exploratory Studies Core

Browse our Pilot and Exploratory studies conducted since 2000 with support of the OAIC grant and the outcomes of these studies:

 

Year of Funding

Project Leader

OAIC Pilot/Exploratory Study

Outcomes of Pilot/Exploratory Studies

 2016Kathryn Callahan, MD  Promoting Active Living in Aging: Innovation in Primary CareIn Progress 
 2016 Paul Laurienti, MD, PhD Using baseline brain imaging to predict success in weight loss interventions in older adultsIn Progress 
 2016 Osvaldo Delbono, PhD The Sympathetic Nervous System Regulates the Stability of the Neuromuscular Junction with AgingIn Progress 

  2015

Bharathi Upadhya, MD 

Rehabilitation and Exercise Training after Hospitalization: Assessing Benefit in patients undergoing transcatheter aortic valve replacement for aortic stenosis (REHAB-AS Pilot Study)

 In Progress - Recruitment and Follow up underway

  2015

Carol Shively, PhD / Anthony Molina, PhD

 Mediterranean Diet Effects on NHP Mitochondrial Bioenergetics & Physical Function

 In Progress

  2015

 Robert Kraft, PhD

 Determining the Role of Skeletal Muscle in Heart Failure Patients

 In Progress

 2015

Killian Robinson, MD 

 Pathways to Improving Functional Capacity in Older Patients with Chronic Kidney Disease and Cardiovascular Disease

In Progress

 2015

Tan Zhang, PhD 

 Cardiac Troponin T and Skeletal Muscle Dysfunction in older adults with Obesity and Heart Failure

Completed 

 2014

Anthony Molina, PhD 

The effects of Vitamin D supplementation on mitochondrial bioenergentics in older adults 

In Progress - Recruitment and Follow up underway 

 2014

Kylie Kavanagh, PhD 

Intestinal Integrity Differences with Age 

Completed 

2014 

 Snezana Petrovic, PhD

 Acid-base status as a modifier of loss of muscle during intentional weight loss in older adults

Completed -  R21 awarded

2013 

Osvaldo Delbono, PhD

Pericyte Subtype Balance Determines the Success of Muscle Repair with Aging

 Completed - R01 awarded and AFAR scholarship to new investigator

 2013

 Jamy Ard, MD

Impact of Medical Weight Loss on Physical Function in Severely Obese Older Adults 

Completed 

2012

Christina Hugenschmidt, PhD

Section on Gerontology and Geriatric Medicine

Using Brain Function as a Metric to Predict Physical Performance in Obese Older Adults

Completed

2012

Katherine Saul, PhD

Bio

Upper limb kinematics and muscular compensation during activities of daily living in older adults with rotator cuff impairment

Completed

2012

Daniel Clark Files, MD

 

The Effect of Age on Recovery from Acute Lung Injury-Induced Skeletal Muscle Wasting in Mice

Completed

2012

Kylie Kavanagh, PhD

 

Preservation of Muscle Performance and Metabolism in Aging through HSP Induction

Completed

2012

Anthony Molina, PhD

Section on Gerontology and Geriatric Medicine

The Role of Bioenergetics and Mitochondrial Quality Control in Promoting Physical Ability in Older Adults

Completed

2011

Richard Loeser MD / Kyla Shea PhD
Molecular Medicine / Section on Gerontology and Geriatric Medicine

Vitamin K Deficiency and Osteoarthritis

Completed

2011

Kristen Beavers PhD / Mara Vitolins, DrPH, MPH, RD

Section on Gerontology and Geriatric Medicine / Public Health Sciences

Use of a Soy-Based Meal Replacement Weight Loss Intervention to Impact Ectopic Fat and Associated Cardio-Metabolic Risk in Obese, Older Adults: A Feasibility Study

Completed - F32 awarded to K. Beavers

2011

Kyla Shea, PhD
Section on Gerontology and Geriatric Medicine

Vitamin K and D Status and Physical Function in Heart Failure

Completed - Arthritis Foundation New Investigators grant awarded

2011

Mark Haykowsky, PhD and Dalane Kitzman, MD

Determinants of Exercise Intolerance in Older Patients with Heart Failure and Preserve Ejection Fraction

Exploratory Project

2010

John Stehle, PhD

Dept of Internal Medicine Section on Gerontology and Geriatric Medicine

Age, Body Composition, Functional Status and Immune Function in African Green Monkeys

In Progress; K01 submitted

2010

Debra I. Diz, PhD, FAHA Hypertension & Vascular Research Center

Brain Transmitters as Markers of Autonomic Profiling in the Elderly

In Progress

2010

Osvaldo Delbono, MD, PhD

Dept of Internal Medicine Section on Gerontology and Geriatric Medicine

Reciprocal Influence Between Denervation and Progenitor Cells Depletion in Sarcopenia

In Progress; R21 awarded

2010

Denise Houston, PhD

Section on Gerontology & Geriatric Medicine

Vitamin D and Physical Function in Older Adults: Cardiovascular Allstars.

Exploratory Project

2010

Denise Houston, PhD

Section on Gerontology & Geriatric Medicine

Vitamin D and Physical Function in Older Adults: Health ABC.

Exploratory Project

2010

Jack Rejeski, PhD

Health & Exercise Sciences

Dependence of Mobility on Weight Loss and Fitness in Overweight Adults with Type 2 Diabetes.

Exploratory Project

2009

Susan Butler, PhD, CCC-SLP

Otolaryngology

Computed Tomography (CT) Imaging of Lingual Muscle/Fat Composition in Community-Dwelling Older Adult Aspirators and Non-Aspirators

Completed; R01 submitted, R21 submitted.

2009

Hang Shi, Ph.D.

Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine

Molecular Characterization of Adipose Density by Non-Invasive Imaging in Humans and Non-Human Primates

 

Completed; R01 awarded.

2009

Kylie Kavanagh, DVM

Pathology / Primate Ctr

Skeletal Muscle Chaperone Proteins And Metabolic Function In Aging

Completed; R21 submitted to NHLBI, K01 awarded.

2009

Carol A. Shively, PhD           Pathology/Comparative Medicine

Aging and Physical Function in Primates

 

Completed; R21 submitted

2009

Mark Van Dyke, PhD         Regenerative Medicine

The impact of aging on the proliferation and differentiation potential of intramuscular adipose derived stem cells

Completed; R21 awarded (Matthew Stern)

2009

Tina Brinkley, PhD

Section on Gerontology & Geriatric Medicine

Inflammation, Physical Function, and Comorbidity in Older Adults

Exploratory Project

2009

Kyla Shea, PhD

Section on Gerontology & Geriatric Medicine

Intentional Weight Loss and Mortality in Older Adults in the TONE Study.

Exploratory Project

2009

Kyla Shea, PhD

Section on Gerontology & Geriatric Medicine

Intentional Weight Loss and Mortality in Older Adults in the ADAPT Study

Exploratory Project

2008

Michael Berry, PhD

Health and Exercise Sciences, Wake Forest University

Strength Training in Patients with Chronic Obstructive Pulmonary Disease (REACT-3)

Completed

2008

Osvaldo Delbono, PhD

Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine

Preclinical, noninvasive assessment of aging skeletal muscle denervation with positron emission tomography (PET)

Completed; R21 awarded.

2008

Raghunatha Yammani, PhD

Section of Molecular Medicine

Leptin and Cartilage Degradation: An Adiposity-Osteoarthritis Link

 

Completed.

2008

Barbara Nicklas, PhD

Section on Gerontology & Geriatric Medicine

Aging, Physical Function, and Muscle Phenotypes

Exploratory Project

2008

X Wang, PhD

Physical Activity and Weight Regain After Weight Loss.

Exploratory Project

2007

Erica Hartmann, MD

Internal Medicine and Nephrology

Impact of a Physical Activity Intervention on Physical Function and Quality of Life in Aging    Candidates for Renal Transplantation (PART)

Extension of 2005 pilot

Completed

2007

Denise Houston, PhD

Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine

Vitamin D status, VDR polymorphisms, and physical function in older adults

Completed; K01 awarded, MERCK industry award

2007

Denise Houston, PhD

Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine

Vitamin D Deficiency and Physical Function in the Elderly

Exploratory Project

2007

Dalane Kitzman, MD

Dept. of Internal Medicine/Cardiology

Effect of Physiologic Maneuvers on Cardiovascular Function (HEALTHY)

Completed; R01 awarded.

2007

 

Gregory Hundley, MD

Dept. of Internal Medicine/Cardiology

Contribution of Arterial Dysfunction to Symptoms of Exercise Limitation in Older Heart Failure Patients

Exploratory Project

2006

Peter E. Morris, MD 

Pulmonary and Critical Care Medicine

Effect Of Acute Inflammatory Mediators On Duration Of Functional Limitations In Elderly Patients With Acute Respiratory Failure

Completed; RO1 awarded.

2006

Mike Madigan, PhD

Engineering Science and Mechanics

VT-WF School of Biomedical Engineering

 

Kevin Davy, PhD

Human Nutrition, Foods and Exercise

VT-WF School of Biomedical Engineering

Effects of Sarcopenic Obesity on Recovery from a Trip

Completed

2005

Delrae Eckman, PhD

PPAR Activators and Physical Function in Old Rats

Completed

2005

Gary Miller, PhD

Health and Exercise Science

Does Weight Loss Following Laparoscopic Roux-en-Y Gastric Bypass Improve Physical Function?" (Pilot)

Completed

2005

Erica Hartmann, MD

Internal Medicine and Nephrology

Impact of an Exercise Program on Physical Function, Body Composition,

and Quality of Life in Aging Recipients of Renal Allografts (Pilot)

Completed; ASN / ASP Award

2005

Jingzhong Ding, MD

Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine 

Pericardial fat and subclinical and clinical measures of cardiovascular disease in a multi-ethnic sample of US adults (Pilot)

Completed; R01 funded HL085323

2005

Lynne Wagenknecht, MD

Department of Public Health Sciences, Epidemiology

Metabolic and Genetic Determinants of Non-Alcoholic Fatty Liver Disease in African-American and Hispanic Americans (Pilot)

Completed

2004

Craig Hamilton, MD

Biomedical Engineering

Optical Imaging of Skeletal Muscle (Pilot)

Completed

2004

Jeff Carr, MD

Radiologic Sciences

Developing CT Measures of Adiposity and Body Composition for Application in Population-based and Genomic Research (Pilot)

Completed

2004

Tongjian You, PhD

Dept. of Internal Medicine/Geriatrics

Effects of Caloric Restriction on Physical Performance in Aged Rats (Pilot)

Completed

K award in preparation

2002-2003

Gregory Hundley, MD
Dept. of Internal Medicine/Cardiology

Leg blood flow, sarcopenia and physical function (Pilot)

Completed

2002-2003

Anthony P. Marsh, PhD
Health and Exercise Science

Power training in older adults: mechanisms underlying change in muscle function (Pilot)

Completed

2002-2003

Anthony P. Marsh, PhD
Health and Exercise Science

Effect of muscle power on disability: analyses of the InChianti Study (Exploratory Study)

Completed

2002-2003

Capri Foy, PhD
Dept. of Health & Exercise Science

Pro-social Behavior as a Motivation Facilitator of an Exercise Adherence Among Older Adults: A Preliminary Study (Pilot)

Completed; R21 funded.

2002-2003

Graziano Onder, MD
Dept. of Internal Medicine/Geriatrics

Effects of ACE inhibitors on skeletal muscle and physical disability in older adults (Exploratory Study)

Completed

2002-2003

Dora Il'yasova, PhD
Cancer Control and Prevention

Relationships Between Biomarkers of the Systemic Oxidative Stress 8-ISO-PGF-M, Systemic Inflammatory Markers, and Muscular Function (Pilot)

Completed

 

2001-2002

Suzy Torti, PhD

Biochemistry

IGF1 in Aging and Cancer: Role of Modulation of Iron Metabolism and Oxidative Stress (Pilot)

Completed

2001-2002

Osvaldo Delbono, MD, PhD
Dept. of Physiology/Pharmacology
Dep. of Internal Medicine/Geriatrics

Gene therapy of sarcopenia

(Pilot)

Completed

 

2001-2002

Dalane Kitzman, MD
Dept. of Internal Medicine/Cardiology

Effects of spironolactone on exercise tolerance and quality of life in older subjects with diastolic heart failure (Pilot)

Exercise Intolerance in Elderly Diastolic Heart Failure- R01-recently funded.

2001-2002

Dalane Kitzman, MD
Dept. of Internal Medicine/Cardiology

Potential Contribution of Inflammation and Skeletal Muscle Loss to Disability in Older Patients with Diastolic Heart Failure and the Potential Role of ACE-I Therapy (Pilot)

Exercise Intolerance in Elderly Diastolic Heart Failure- R01 has been submitted.

Work continuing to complete trial in 2005.

2001-2002

Brenda Penninx, PhD
Dept. of Internal Medicine/Geriatrics

Antidepressants and physical exercise in older persons with minor depression (Pilot)

Completed

Manuscript and Grant in Preparation

2000-2001

Jeff Williamson, MD
Dept. of Internal Medicine/Geriatrics

Efficacy of exercise with and without ACE inhibition in improving extremity strength, function and muscle mass in older adults (Pilot)

ACE Inhibitors and Functional Decline in High Risk Older Adults, NIH grant application in preparation (2001)

2000-2001

Christy S. Carter, PhD
Dept. of Internal Medicine/Geriatrics

Long-term effects of enalapril and rofecoxib on physical performance in aging rats (Pilot)

Modeling preclinical disability in aged rats. NIH, NGA: 3 P60 AG10484-10S1 (PI: Pahor) 2001-2002

 

Modeling preclinical disability in aged rats. NIH, NGA: 1 R03AG019936-01 (PI: Pahor) 2001-2002

 

 

 

Last Updated: 05-09-2016
USNWR 2015-2016Magnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.