Year of Funding | Project Leader | OAIC Pilot/Exploratory Study | Outcomes of Pilot/Exploratory Studies |
2012 | Christina Hugenschmidt, PhD Section on Gerontology and Geriatric Medicine | Using Brain Function as a Metric to Predict Physical Performance in Obese Older Adults | In Progress |
2012 | Katherine Saul, PhD Bio | Upper limb kinematics and muscular compensation during activities of daily living in older adults with rotator cuff impairment | In Progress |
2012 | Daniel Clark Files, MD | The Effect of Age on Recovery from Acute Lung Injury-Induced Skeletal Muscle Wasting in Mice | In Progress |
2012 | Kylie Kavanagh, PhD | Preservation of Muscle Performance and Metabolism in Aging through HSP Induction | In Progress |
2012 | Anthony Molina, PhD Section on Gerontology and Geriatric Medicine | The Role of Bioenergetics and Mitochondrial Quality Control in Promoting Physical Ability in Older Adults | In Progress |
2011 | Richard Loeser MD / Kyla Shea PhD
Molecular Medicine / Section on Gerontology and Geriatric Medicine | Vitamin K Deficiency and Osteoarthritis | In Progress |
2011 | Kristen Beavers PhD / Mara Vitolins, DrPH, MPH, RD Section on Gerontology and Geriatric Medicine / Public Health Sciences | Use of a Soy-Based Meal Replacement Weight Loss Intervention to Impact Ectopic Fat and Associated Cardio-Metabolic Risk in Obese, Older Adults: A Feasibility Study | In Progress F32 awarded to K. Beavers |
2011 | Kyla Shea, PhD
Section on Gerontology and Geriatric Medicine | Vitamin K and D Status and Physical Function in Heart Failure | In Progress Arthritis Foundation New Investigators grant awarded |
2011 | Mark Haykowsky, PhD and Dalane Kitzman, MD | Determinants of Exercise Intolerance in Older Patients with Heart Failure and Preserve Ejection Fraction | Exploratory Project |
2010 | John Stehle, PhD Dept of Internal Medicine Section on Gerontology and Geriatric Medicine | Age, Body Composition, Functional Status and Immune Function in African Green Monkeys | In Progress; K01 submitted |
2010 | Debra I. Diz, PhD, FAHA Hypertension & Vascular Research Center | Brain Transmitters as Markers of Autonomic Profiling in the Elderly | In Progress |
2010 | Osvaldo Delbono, MD, PhD Dept of Internal Medicine Section on Gerontology and Geriatric Medicine | Reciprocal Influence Between Denervation and Progenitor Cells Depletion in Sarcopenia | In Progress; R21 awarded |
2010 | Denise Houston, PhD Section on Gerontology & Geriatric Medicine | Vitamin D and Physical Function in Older Adults: Cardiovascular Allstars. | Exploratory Project |
2010 | Denise Houston, PhD Section on Gerontology & Geriatric Medicine | Vitamin D and Physical Function in Older Adults: Health ABC. | Exploratory Project |
2010 | Jack Rejeski, PhD Health & Exercise Sciences | Dependence of Mobility on Weight Loss and Fitness in Overweight Adults with Type 2 Diabetes. | Exploratory Project |
2009 | Susan Butler, PhD, CCC-SLP Otolaryngology | Computed Tomography (CT) Imaging of Lingual Muscle/Fat Composition in Community-Dwelling Older Adult Aspirators and Non-Aspirators | Completed; R01 submitted, R21 submitted. |
2009 | Hang Shi, Ph.D. Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine | Molecular Characterization of Adipose Density by Non-Invasive Imaging in Humans and Non-Human Primates | Completed; R01 awarded. |
2009 | Kylie Kavanagh, DVM Pathology / Primate Ctr | Skeletal Muscle Chaperone Proteins And Metabolic Function In Aging | Completed; R21 submitted to NHLBI, K01 awarded. |
2009 | Carol A. Shively, PhD Pathology/Comparative Medicine | Aging and Physical Function in Primates | Completed; R21 submitted |
2009 | Mark Van Dyke, PhD Regenerative Medicine | The impact of aging on the proliferation and differentiation potential of intramuscular adipose derived stem cells | Completed; R21 awarded (Matthew Stern) |
2009 | Tina Brinkley, PhD Section on Gerontology & Geriatric Medicine | Inflammation, Physical Function, and Comorbidity in Older Adults | Exploratory Project |
2009 | Kyla Shea, PhD Section on Gerontology & Geriatric Medicine | Intentional Weight Loss and Mortality in Older Adults in the TONE Study. | Exploratory Project |
2009 | Kyla Shea, PhD Section on Gerontology & Geriatric Medicine | Intentional Weight Loss and Mortality in Older Adults in the ADAPT Study | Exploratory Project |
2008 | Michael Berry, PhD Health and Exercise Sciences, Wake Forest University | Strength Training in Patients with Chronic Obstructive Pulmonary Disease (REACT-3) | Completed |
2008 | Osvaldo Delbono, PhD Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine | Preclinical, noninvasive assessment of aging skeletal muscle denervation with positron emission tomography (PET) | Completed; R21 awarded. |
2008 | Raghunatha Yammani, PhD Section of Molecular Medicine | Leptin and Cartilage Degradation: An Adiposity-Osteoarthritis Link | Completed. |
2008 | Barbara Nicklas, PhD Section on Gerontology & Geriatric Medicine | Aging, Physical Function, and Muscle Phenotypes | Exploratory Project |
2008 | X Wang, PhD | Physical Activity and Weight Regain After Weight Loss. | Exploratory Project |
2007 | Erica Hartmann, MD Internal Medicine and Nephrology | Impact of a Physical Activity Intervention on Physical Function and Quality of Life in Aging Candidates for Renal Transplantation (PART) Extension of 2005 pilot | Completed |
2007 | Denise Houston, PhD Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine | Vitamin D status, VDR polymorphisms, and physical function in older adults | Completed; K01 awarded, MERCK industry award |
2007 | Denise Houston, PhD Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine | Vitamin D Deficiency and Physical Function in the Elderly | Exploratory Project |
2007 | Dalane Kitzman, MD Dept. of Internal Medicine/Cardiology | Effect of Physiologic Maneuvers on Cardiovascular Function (HEALTHY) | Completed; R01 awarded. |
2007 | Gregory Hundley, MD Dept. of Internal Medicine/Cardiology | Contribution of Arterial Dysfunction to Symptoms of Exercise Limitation in Older Heart Failure Patients | Exploratory Project |
2006 | Peter E. Morris, MD Pulmonary and Critical Care Medicine | Effect Of Acute Inflammatory Mediators On Duration Of Functional Limitations In Elderly Patients With Acute Respiratory Failure | Completed; RO1 awarded. |
2006 | Mike Madigan, PhD Engineering Science and Mechanics VT-WF School of Biomedical Engineering Kevin Davy, PhD Human Nutrition, Foods and Exercise VT-WF School of Biomedical Engineering | Effects of Sarcopenic Obesity on Recovery from a Trip | Completed |
2005 | Delrae Eckman, PhD | PPAR Activators and Physical Function in Old Rats | Completed |
2005 | Gary Miller, PhD Health and Exercise Science | Does Weight Loss Following Laparoscopic Roux-en-Y Gastric Bypass Improve Physical Function?" (Pilot) | Completed |
2005 | Erica Hartmann, MD Internal Medicine and Nephrology | Impact of an Exercise Program on Physical Function, Body Composition, and Quality of Life in Aging Recipients of Renal Allografts (Pilot) | Completed; ASN / ASP Award |
2005 | Jingzhong Ding, MD Dept. of Internal Medicine Section on Gerontology and Geriatric Medicine | Pericardial fat and subclinical and clinical measures of cardiovascular disease in a multi-ethnic sample of US adults (Pilot) | Completed; R01 funded HL085323 |
2005 | Lynne Wagenknecht, MD Department of Public Health Sciences, Epidemiology | Metabolic and Genetic Determinants of Non-Alcoholic Fatty Liver Disease in African-American and Hispanic Americans (Pilot) | Completed |
2004 | Craig Hamilton, MD Biomedical Engineering | Optical Imaging of Skeletal Muscle (Pilot) | Completed |
2004 | Jeff Carr, MD Radiologic Sciences | Developing CT Measures of Adiposity and Body Composition for Application in Population-based and Genomic Research (Pilot) | Completed |
2004 | Tongjian You, PhD Dept. of Internal Medicine/Geriatrics | Effects of Caloric Restriction on Physical Performance in Aged Rats (Pilot) | Completed K award in preparation |
2002-2003 | Gregory Hundley, MD
Dept. of Internal Medicine/Cardiology | Leg blood flow, sarcopenia and physical function (Pilot) | Completed |
2002-2003 | Anthony P. Marsh, PhD
Health and Exercise Science | Power training in older adults: mechanisms underlying change in muscle function (Pilot) | Completed |
2002-2003 | Anthony P. Marsh, PhD
Health and Exercise Science | Effect of muscle power on disability: analyses of the InChianti Study (Exploratory Study) | Completed |
2002-2003 | Capri Foy, PhD
Dept. of Health & Exercise Science | Pro-social Behavior as a Motivation Facilitator of an Exercise Adherence Among Older Adults: A Preliminary Study (Pilot) | Completed; R21 funded. |
2002-2003 | Graziano Onder, MD
Dept. of Internal Medicine/Geriatrics | Effects of ACE inhibitors on skeletal muscle and physical disability in older adults (Exploratory Study) | Completed |
2002-2003 | Dora Il'yasova, PhD
Cancer Control and Prevention | Relationships Between Biomarkers of the Systemic Oxidative Stress 8-ISO-PGF-M, Systemic Inflammatory Markers, and Muscular Function (Pilot) | Completed |
2001-2002 | Suzy Torti, PhD Biochemistry | IGF1 in Aging and Cancer: Role of Modulation of Iron Metabolism and Oxidative Stress (Pilot) | Completed |
2001-2002 | Osvaldo Delbono, MD, PhD
Dept. of Physiology/Pharmacology
Dep. of Internal Medicine/Geriatrics | Gene therapy of sarcopenia (Pilot) | Completed |
2001-2002 | Dalane Kitzman, MD
Dept. of Internal Medicine/Cardiology | Effects of spironolactone on exercise tolerance and quality of life in older subjects with diastolic heart failure (Pilot) | Exercise Intolerance in Elderly Diastolic Heart Failure- R01-recently funded. |
2001-2002 | Dalane Kitzman, MD
Dept. of Internal Medicine/Cardiology | Potential Contribution of Inflammation and Skeletal Muscle Loss to Disability in Older Patients with Diastolic Heart Failure and the Potential Role of ACE-I Therapy (Pilot) | Exercise Intolerance in Elderly Diastolic Heart Failure- R01 has been submitted. Work continuing to complete trial in 2005. |
2001-2002 | Brenda Penninx, PhD
Dept. of Internal Medicine/Geriatrics | Antidepressants and physical exercise in older persons with minor depression (Pilot) | Completed Manuscript and Grant in Preparation |
2000-2001 | Jeff Williamson, MD
Dept. of Internal Medicine/Geriatrics | Efficacy of exercise with and without ACE inhibition in improving extremity strength, function and muscle mass in older adults (Pilot) | ACE Inhibitors and Functional Decline in High Risk Older Adults, NIH grant application in preparation (2001) |
2000-2001 | Christy S. Carter, PhD
Dept. of Internal Medicine/Geriatrics | Long-term effects of enalapril and rofecoxib on physical performance in aging rats (Pilot) | Modeling preclinical disability in aged rats. NIH, NGA: 3 P60 AG10484-10S1 (PI: Pahor) 2001-2002 Modeling preclinical disability in aged rats. NIH, NGA: 1 R03AG019936-01 (PI: Pahor) 2001-2002 |