Pulmonary, Critical Care, Allergy & Immunological Diseases Research
In the Section on Pulmonary, Critical Care, Allergy
& Immunological Diseases, faculty members conduct a wide variety
of clinical, translational, and molecular research programs.
clinical research activities in airways
disease are focused on the detailed characterization of patients with asthma,
chronic obstructive pulmonary disease (COPD), and cystic fibrosis. The Wake
Forest airways disease research group has internationally recognized expertise
in the identification of specific disease subgroups with the use of detailed
clinical and genomic data for the development of personalized, precision
therapeutic interventions. These studies range from industry-sponsored clinical
trials evaluating novel therapeutic drugs to large multi-center networks conducting
innovative clinical trials with detailed clinical and genomic characterization
of individuals with airways disease. These studies are performed in the Center for Genomics and Personalized
Medicine Research in the Wake Forest School of Medicine.
areas of focus include:
Ongoing research activities in critical care focus on resolution
of lung injury and functional recovery of the critically ill patient using
basic through implementation science methodologies. Many of these activities
are facilitated through interaction with the Wake
Forest Critical Illness, Injury and Recovery Research Center.
Thematic areas of focus include:
- Clinical trials in critical care focused on the
prevention and early treatment of lung injury, sponsored through activity in
the NHLBI PETAL Network.
- Translational science, clinical trials and quality
improvement in the field of early mobility and functional outcomes in critical
- Lung injury and injury resolution with a focus on
surfactant injury, innate and adaptive immune responses and metabolism.
- Patient-centered recovery research including the Wake Forest ICU Recovery Clinic and participation
in the PCOR-ICUand
SCCM Thrive Network.
- Industry-sponsored critical care trials.
Ongoing research activities in lung cancer and interventional pulmonology focus on lung cancer screening, bronchology,
and precision medicine. Ongoing
partnerships in this area include participation in industry-sponsored trials in
lung cancer and bronchoscopy.
Ongoing research in sleep medicine includes:
- An institutional sleep apnea screening system and
sleep registry aimed at early identification sleep disordered breathing to
improve patient outcomes across the health system.
- Clinical trials in sleep screening both inpatient and
outpatient services .
- Epidemiologic research in physician reporting of sleep
apnea nation wide.
research in allergy and immunology
includes genetic characterization of
immune mediated disorders, vocal
cord dysfunction, and epinephrine
areas of active investigation include complications from asbestos exposure and opiate
injection drug use, problems of high prevalence in our region.