Pulmonary, Critical Care, Allergy & Immunological Diseases Research

In the Section on Pulmonary, Critical Care, Allergy & Immunological Diseases, faculty members conduct a wide variety of clinical, translational, and molecular research programs. 

Ongoing clinical research activities in airways disease are focused on the detailed characterization of patients with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. The Wake Forest airways disease research group has internationally recognized expertise in the identification of specific disease subgroups with the use of detailed clinical and genomic data for the development of personalized, precision therapeutic interventions. These studies range from industry-sponsored clinical trials evaluating novel therapeutic drugs to large multi-center networks conducting innovative clinical trials with detailed clinical and genomic characterization of individuals with airways disease. These studies are performed in the Center for Genomics and Personalized Medicine Research in the Wake Forest School of Medicine.

Thematic areas of focus include:

Ongoing research activities in critical care focus on resolution of lung injury and functional recovery of the critically ill patient using basic through implementation science methodologies. Many of these activities are facilitated through interaction with the Wake Forest Critical Illness, Injury and Recovery Research Center.

Thematic areas of focus include:

  • Clinical trials in critical care focused on the prevention and early treatment of lung injury, sponsored through activity in the NHLBI PETAL Network.
  • Translational science, clinical trials and quality improvement in the field of early mobility and functional outcomes in critical care.
  • Lung injury and injury resolution with a focus on surfactant injury, innate and adaptive immune responses and metabolism.
  • Patient-centered recovery research including the Wake Forest ICU Recovery Clinic and participation in the PCOR-ICUand SCCM Thrive Network.
  • Industry-sponsored critical care trials.

Ongoing research activities in lung cancer and interventional pulmonology focus on lung cancer screening, bronchology, and precision medicine. Ongoing partnerships in this area include participation in industry-sponsored trials in lung cancer and bronchoscopy.

Ongoing research in sleep medicine includes:

  • An institutional sleep apnea screening system and sleep registry aimed at early identification sleep disordered breathing to improve patient outcomes across the health system.
  • Clinical trials in sleep screening both inpatient and outpatient services .
  • Epidemiologic research in physician reporting of sleep apnea nation wide.

Ongoing research in allergy and immunology includes genetic characterization of immune mediated disorders, vocal cord dysfunction, and epinephrine shortages

Other areas of active investigation include complications from asbestos exposure and opiate injection drug use, problems of high prevalence in our region. 

Last Updated: 09-28-2016
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