Pulmonary, Critical Care, Allergy & Immunological Diseases Research

Pulm Research Staff

In the Section on Pulmonary, Critical Care, Allergy & Immunological Diseases, faculty members conduct a wide variety of  clinical, translational, and molecular research programs.  This is accomplished within both the Section and the Center for Human Genomics and Personalized Medicine, which is co-directed by Eugene Bleecker, MD and Deborah Meyers, PhD. 

Among the ongoing clinical research activities are:

  • clinical trials in asthma and chronic obstructive pulmonary disease that are performed in the Cloverdale Clinical Research facility by Eugene Bleecker, MD, Stephen Peters, MD, PhD, Wendy Moore, MD;
  • a clinical site for the NHLBI's Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet, Principal Investigator Stephen P. Peters, MD, PhD
  • a clinical site for the NHLBI's Asthma Clinical Research Network, principal investigator Stephen Peters, MD, PhD and
  • the NHLBI Severe Asthma Research Program, Principal Investigator Eugene R. Bleecker, MD.
  • the NHLBI SPIROMICS Contract, Principal Investigator, Eugene R. Bleecker, MD, Co-Investigators, Jill Ohar, MD and Stephen P. Peters, MD
  • clinical, physiologic, and genetic characterizations of individuals at risk or exposed to potentially harmful occupational agents including asbestos, Director Jill Ohar, MD.

Physicians Hite and Morris conduct clinical trials on acute respiratory distress syndrome (ARDS), sepsis and pneumonia in the Intensive Care Units of Wake Forest Baptist Medical Center, which serves as a clinical site for the NHLBI's ARDS Network. 

Morris PE, Herridge MS.

Related Articles

Early intensive care unit mobility: future directions.
Crit Care Clin. 2007 Jan;23(1):97-110. Review.
PMID: 17307119 [PubMed - indexed for MEDLINE]


Work supported by the NHLBI is performed in the genetics of asthma, atopy, and related diseases by Principal Investigator Deborah Meyers, PhD and Eugene Bleecker, MD, and as part of an NHLBI Specialized Center of Research (SCOR) in asthma by Principal Investigator Stephen Peters, MD, PhD.

Within this Section, molecular investigations supported by the NIH include:

  • epithelial and mesenchymal cell biology in asthma by Stephen Peters, MD, PhD and Annette Hastie, PhD,
  • and studies associating genetic haplotypes with diseases, disease-related phenotypes, and the response to medications used to treat these diseases by Eugene Bleecker, MD, Deborah Meyers, PhD, Gregory Hawkins, PhD, Timothy Howard, PhD, Stephen Peters, MD, PhD. 

Dr. Duncan Hite's laboratory works in collaboration with Dr. Michael Seeds from the Department of Molecular Medicine who focuses on phospholipase-mediated surfactant injury in asthma and ARDS and cell injury and death.

Hite RD, Seeds MC, Jacinto RB, Grier BL, Waite BM, Bass DA.

Related Articles

Lysophospholipid and fatty acid inhibition of pulmonary surfactant: non-enzymatic models of phospholipase A2 surfactant hydrolysis.
Biochim Biophys Acta. 2005 Dec 30;1720(1-2):14-21. Epub 2005 Nov 21.
PMID: 16376294 [PubMed - indexed for MEDLINE]

 

Hite RD, Seeds MC, Safta AM, Jacinto RB, Gyves JI, Bass DA, Waite BM.

Related Articles

Lysophospholipid generation and phosphatidylglycerol depletion in phospholipase A(2)-mediated surfactant dysfunction.
Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L618-24. Epub 2004 Oct 29.
PMID: 15516491 [PubMed - indexed for MEDLINE]

 

Hite RD, Seeds MC, Bowton DL, Grier BL, Safta AM, Balkrishnan R, Waite BM, Bass DA.

Related Articles

Surfactant phospholipid changes after antigen challenge: a role for phosphatidylglycerol in dysfunction.
Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L610-7. Epub 2004 Sep 3.
PMID: 15347567 [PubMed - indexed for MEDLINE]


The Center for Human Genomics, which includes individuals in the Departments of Pediatrics, Biochemistry, and Public Health Sciences, as well as the Department of Internal Medicine, also has extensive, NIH-funded programs in:

  • the genetics of prostate cancer, Principal Investigator Jianfeng Xu, MD, MPH,
  • polymorphisms of signal pathways and female cancer, and genomewide linkage for prostate cancer susceptibility, Principal Investigator Siqun Zheng, M.D.
  • complications of diabetes, Principal Investigator  Donald Bowden, PhD, and cardiovascular diseases, Principal Investigator David Herrington, MD,  and Timothy Howard, PhD.
Last Updated: 03-19-2014
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