Research Grants

Below is a list of current grants in which the Pulmonary, Critical Care, Allergy and Immunologic Diseases’ faculty is involved. 

Faculty Member

Grants (Active/Pending)

R. Duncan Hite, MD

ACTIVE:

 

 NIH-RO1-HL085248-01A1, NHLBI   Hite (PI)   2007-2013 
 "Phospholipase A2-mediated surfactant hydrolysis and dysfunction in ALI and ARDS."
 Goal:  Translational human project examining the role and mechanisms by which phospholipase- mediated surfactant injury contributes to the progression and clinical course of ALI/ARDS.

 

N01-HR-56175     NIH, NHLBI   Hite (PI),   2005-2013
Clinical Centers for a Clinical Research Network for the Treatment of the Adult Respiratory Distress Syndrome (ARDS)
Goal:  Develop and execute clinical trials aimed to improve outcomes in patients with ALI/ARDS

 

NHLBI, 1 U01 HL102547-01    Hite (PI, subcontract)  2010-2013
 A randomized double-blind placebo-controlled trial of Ganciclovir/valganciclovir for prevention of cytomegalovirus Reactivation in Acute Injury of the Lung:   The GRAIL Study
 PI: Boeckh M, Limaye A. (Univ Washington, Seattle)

 

NIAID, BAA-DMID-NIHAI2009058  Hite (PI, subcontract)  2011- 2016
 Impact of aggressive empiric antibiotic therapy and duration of therapy on the emergence of antimicrobial resistance during the treatment of ventilator-associated pneumonia (VAP)

 

NIA-C, 1 R01 AG035117-01A1  Hite (PI, subcontract)  2011-2016
 The MIND-USA Study:  Modifying the impact of ICU-Induced Neurological Dysfunction
 PI:  Ely EW (Vanderbilt University, Nashville)

 

PENDING:
6.  RFA-HL-12-022   Hite (PI, subcontract)   2013-2015
Phase II Clinical Trials of Novel Therapies for Lung Diseases (UM1).
Project Title: Vitamin C infusion for treatment in sepsis induced acute lung injury (CITRIS-ALI) 
 Project P.I. (A. Fowler; Richmond, VA)

 

RFP-NHLBI-HR-14-03 Hite (PI)    2013-2020
 Clinical Center for a Clinical Trials Research Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL Network)
     Project Title:   Wake Forest Clinical Center

 

 2RO1-HL-085248-06, NHLBI   Hite (PI)   2013-2018 
 "Phospholipase A2-mediated surfactant hydrolysis and dysfunction in ALI and ARDS."

D. Clark Files, MD

Funded Awards

 

Pepper Center Pilot Study-P30 AG21332   Files (PI)
2/12/12-2/12/13  
The Effect of Age on Recovery from Acute Lung Injury-Induced Skeletal Muscle Wasting in Mice

 

Parker B Francis Fellowship Award                Files (PI)
7/01/12-6/30/15
The Role of MuRF1 in Acute Lung Injury-Induced Skeletal Muscle Wasting

 

Pending
1R03AG045106-01                                                   Files (PI)
7/13-6/15 NIA
Muscle Wasting Promotes Lung Injury in Old Mice
Grants for Early Medical/Surgical Specialists Transition to Aging Research (GEMSTARR)

 

1K08AG045972-01                                                                     Files (PI)
7/13-6/18 NIA
Impaired Recovery of Muscle Function in Old Mice with Acute Lung Injury
K08 Paul Beeson Clinical Scientist Development Award in Aging

Peter E. Morris, MD

ACTIVE:

 

Dept. of the Army, ERMS# 12340010  (Morris 10%)     9/01/12-8/01/15
Early ICU Standardized Rehabilitation Therapy for the Critically Injured Burn Patient. The major goal of this project is to demonstrate that Standardized Rehabilitation Therapy, initiated for Burn patients with Acute Respiratory Failure will demonstrate improvement in function and quality of life.

 

R01 NR011186 (Morris 20%)     03/01/09-03/31/14
Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
The major goal of this project is to demonstrate that Standardized Rehabilitation Therapy, initiated in the ICU, reduces hospital stay with immediate and sustained improvement in function and quality of life for patients with acute respiratory failure.

 

N01HR56175-6-0-3   (Hite- PI, Morris Co-PI, 2%)     05/01/07-04/30/12
Clinical Centers for the Clinical Network for Treatment of the Adult Respiratory Distress Syndrome
This project is to support the participation of a 3-center cluster (Wake Forest School of Medicine, University of Virginia, and Moses Cone Health System) in the national network of clinical trials of acute lung injury.
Role: Co-Investigator

Jill A. Ohar, MD

ACTIVE:

 

Mesothelioma Applied Research Foundation (MARF):  60% effort, 2011-2013. "Consortium for the sharing of germ line DNA and tissue from subjects with mesothelioma."  (PI-Ohar).

 

PENDING:
Mesothelioma Applied Research Foundation (MARF):  60% effort, 2012-2014. "Rare Variant SNP Analysis of Germline DNA in Mesothelioma patients vs. Asbestos-Exposed Controls."  (PI-Ohar).

 

"BAP1 Mutations cause cancer including mesothelioma in asbestos exposed subjects"1-1-13-12-31-13 CCCWFU Pilot Grant

Stephen P. Peters, MD, PhD

ACTIVE:

 

2009-2016 "Spiromics" Clinical Center.  HHSN268200900019C.  Eugene R. Bleecker, Principal Investigator, Stephen P. Peters, Co-Investigator.  The National Institutes of Health, National Heart, Lung, and Blood Institute. 

 

2009-2016 Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical Site.  U10 HL098103.  Stephen P. Peters, Principal Investigator.  The National Institutes of Health, National Heart, Lung, and Blood Institute.  (September 30, 2009 - September 30, 2016)

 

2011-2017 Longitudinal Phenomics and Genetics of Severe Asthma.  U10 HL109164.  Eugene R. Bleecker, PI, Stephen P. Peters, Co-Investigator.  The National Institutes of Health, National Heart, Lung, and Blood Institute. 

Wendy Moore, MD

ACTIVE:

 

NIH/NHLBI       
Severe Asthma Research Program
"Longitudinal phenomics and genetics of severe asthma"  7/2011 - 6/2018
Principal Investigator: Eugene R. Bleecker;    Role: Co-Investigator   

 

NIH/NHLBI
"Efficacy and biomarker discovery of Vitamin D3 in the management of severe asthma"
Subcontract from University of Pennsylvania   9/2010 - 8/2013
Principal Investigator: Rey Panettieri, MD   
Role: Co-investigator    

 

NIH/NHLBI
AsthmaNet Clinical Site     
"Atlantic Coast Consortium for Asthma (ACC-A)"     10/2009 - 6/2016 
Principal Investigator: Stephen P. Peters  
Role: Co-investigator     

 

NIH/NHLBI       
"SPIROMICS" Clinical Center     2/2009 - 1/2016
Principal Investigator: Eugene R. Bleecker   
Role: Co-investigator      

Alex O. Sy, MD

Current and Pending:

 

Principal Investigator
Aeris Therapeutics 03-C11-003PLV: Study of the Aeriseal system for hyperinflation reduction in emphysema (ASPIRE). 2012

 

Co-Investigator
A Multicenter, double-blind, randomized, placebo-controlled, intravenous (IV) Administration Trial to Investigate the Effects of Typical and Atypical Antipsychotics on Delirium in Critically Ill Patient (MIND-USA)

 

Co-Investigator
Prospective, Randomized, Multi-center Trial of the Safety and Efficacy of Rosuvastatin for Acutely Injured Lungs from Sepsis (SAILS)

 

Co- Investigator
A Randomized, Double-Blind, Placebo-Controlled Trial of Ganciclovir/Valganciclovir for the Prevention of Cytomegalovirus Reactivation in Patients with Acute Lung Injury

Christina Bellinger, MD

Co-Investigator
Aeris Therapeutics 03-C11-003PLV: Study of the Aeriseal system for hyperinflation reduction in emphysema (ASPIRE). 2012

Matthew Miles, MD

Co-Investigator
Aeris Therapeutics 03-C11-003PLV: Study of the Aeriseal system for hyperinflation reduction in emphysema (ASPIRE). 2012

Sanjay Dhar, MD

ACTIVE:

 

Co Investigator : (TARGET) Trial with Acute Respiratory Failure Patients Evaluation of Global Exercise Therapies
 NIH Title: Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
 Grant Number: 1R01NR011186-01. Wake Forest School of Medicine .2012

 

Co Investigator: (CEASE):"CARDIOPULMONARY EVALUATION OF ALBUMIN AND STARCH EFFECTS IN ALI (CEASE)" FDA TITLE: "PHASE III STUDY COMPARING ALBUMIN AND HETASTARCH IN ACUTE LUNG INJURY. NCT00796419. Wake Forest School Of Medicine 2012

Eugene R. Bleecker, MD

ACTIVE:

 

U01 HL65899 (Weiss-Harvard) (Bleecker-WFUHS) 08/01/2005 - 06/30/2015
NIH/NHLBI  
Pharmacogenetics of Asthma Treatment.

 

1K12HL089992 (Meyers) 09/27/2007 - 07/31/2013
NIH Scholars' Program in the Genetics and Genomics of Lung Diseases.

 

HHSN2682009000019C (Bleecker) 02/01/2009 - 01/31/2016
NIH Spiromics Clinical Center.

 

1T32 HL076132-06A1 (Herrington)  07/01/2004 - 06/30/2014 Mentor
NHLBI  CVD Epidemiology Training Program.

 

1 U10 HL098103 (Peters)  09/30/2009 - 06/30/2016
NIH Atlantic Coast Consortium-for Asthma (ACC-A) AsthmaNet Clinical Site.

 

1U10 HL109164-01 Bleecker (PI) 07/01/2011 - 06/30/2017
NIH-SARP
Longitudinal Phenomics and Genetics of Severe Asthma.

 

Sub with Johns Hopkins (Barnes) (Meyers-WFUHS) 9/28/2011-6/30/2015        
NIH
New Approaches for Empowering Studies in Populations of African Descent.

 

PENDING:
Sub with Emory (Fitzpatrick) (Meyers-WFUHS) 04/01/2013 - 03/31/2018    
NIH
Genomics of Lung Function and Asthma Severity in African Americans.

 

Subcontract with Columbia Univ (Barr), (sub PI Bleecker) 07/01/2013-06/30/2018  
NIH                                                                                                   
SPIROMICS Health Failure Study.

 

Subcontract with Cleveland Clinic (Erzurum) Sub PI (Meyers) 04/1/2013-03/31/2017
NIH
Mechanisms of secondhand smoke effects on asthma

Victor Ortega, MD

ACTIVE:

 

K12 Career Development Award, NIH/NHLBI K12 Program in Genetics and Genomics of Lung Diseases. Wake Forest School of Medicine, Center for Human Genomics; Winston-Salem, NC. Principal Investigator: Deborah A. Meyers, PhD. Program Trainee, July 2010-June 2013

 

NIH Clinical Research Loan Repayment Program. Funded through the National Heart, Lung, and Blood Institute. Contract Awarded June 2011-June 2013

Last Updated: 10-09-2014
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