Ralph B. D'Agostino, PhD

Ralph B. D’Agostino, Ph.D., Professor

Dr. Ralph B. D'Agostino Jr. received his Bachelor's Degree in mathematics from Bowdoin College in 1988. He then attended graduate school at Harvard University where he obtained his Master's Degree (1989) and Ph.D. (1994) in Statistics. Upon graduation in 1994 he joined the faculty in the Department of Public Health Sciences at the Wake Forest School of Medicine. He is currently the Director of the Biostatistics Core for the Comprehensive Cancer Center at Wake Forest and a member of the Wake Forest Institute for Regenerative Medicine. Dr. D'Agostino has more than 100 book chapters and journal articles in the fields of statistics, epidemiology, cancer, cardiovascular disease and diabetes.

SYNOPSIS OF AREA OF INTEREST: Statistical methods for handling missing data; Methods for analyzing data from longitudinal and observational studies; Insulin resistance and its relationship to diabetes, cardiovascular disease and cancer.

DETAILED AREA OF INTEREST: Dr. D'Agostino is currently involved with several statistical research projects. In particular, he is developing methods for handling missing data in epidemiological studies, developing models for longitudinal data that incorporate measurement error, and developing techniques for reducing bias in observational studies using propensity score methods. He is currently the Principal Investigator of an NCI funded R01 grant entitled, "Methods for Epidemiologic Data with Missing Values," and he was previously the PI of a subcontract from the Brigham and Women's Hospital for a NCI/NHLBI grant entitled, "Analysis of Longitudinal CVD and Cancer Data." The aims of these grants focus on developing statistical methodology using actual medical and epidemiological data.

Dr. D'Agostino has also been actively involved in medical research in the areas of cancer, cardiovascular disease, and diabetes. Within the cancer center he is actively involved with developing models using MRI scanning data to identify cancer patients who are treated with chemotherapy that may be at risk for developing heart failure. In addition, he is currently the Deputy Director for the SEARCH for Diabetes in Youth Study and a co-investigator for the Multi-Ethnic Study of Atherosclerosis (MESA)

In addition to his applied and methodological work, Dr. D'Agostino has served as an Associate Editor for the American Journal of Epidemiology and the Journal of Cardiac Failure. He also served as a member of the editorial board for the Current Controlled Trials in Cardiovascular Medicine Journal. He was a member of the NIH, NIDCR Skeletal Biology Development and Disease Study Section (SBDD). He has also served as the Program Chair for the Statistics in Epidemiology Section of the American Statistical Association (ASA) (1998) and the Program Chair for the Health Policy Statistics Section (2000). He was the Secretary/Treasurer for the Biometrics Section of the ASA (2003-05). He currently serves as a regular ad-hoc reviewer for study sections in several institutes of the NIH and the Department of Defense He has also been a member of more than 10 Data Safety Monitoring Committees (DSMBs) of national and international clinical trials.

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Institute for Regenerative Medicine

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