Randolph L. Geary, MD, FACS

Randolph L. Geary, M.D., FACS, Professor of Surgery - Vascular Surgery, Professor of Pathology - Comparative Medicine

Dr. Geary was recruited to Wake Forest in 1994 from the University of Washington, Seattle, where he completed medical school, general surgery residency and a vascular surgery fellowship. While in Seattle, Dr. Geary was awarded an American Heart Association post-doctoral research fellowship in the laboratory of Alexander W. Clowes, M.D., working on regulation of vascular smooth muscle cell growth by blood flow and shear stress as well as on viral vectors for vascular gene transfer. He is currently Professor of Surgery with cross-appointments in the Departments of Pathology - Comparative Medicine and the Wake Forest Institute for Regenerative Medicine. Dr. Geary is active in vascular research exploring how atherosclerotic arteries heal following reconstruction and has a busy clinical practice in vascular surgery.

SYNOPSIS OF AREA OF INTEREST: Arterial injury and repair, constrictive artery wall remodeling, restenosis and blood vessel bioengineering.

DETAILED AREA OF INTEREST: Virtually all forms of arterial reconstruction result in mechanical injury to the artery wall, which stimulates a cascade of injury responses as the vessel heals. In many patients the injury response is excessive, leading to recurrent narrowing of the artery at the site of repair. This is termed "restenosis." Restenosis is an enormous public heath issue given millions of arterial revascularization procedures are performed each year and about one third will fail from restenosis within 2 years (e.g., following angioplasty, stenting, endarterectomy, or arterial bypass). Restenosis has two basic underlying structural explanations - new tissue formation and shrinkage of the artery wall from inward constriction. New tissue forms from hyperplasia of smooth muscle cells in response to cytokines and growth factors released at sites of injury. New artery wall mass then accumulates inside the artery where is can encroach the lumen. As the artery wall heals it may also shrink by reorganizing pre-existing wall components (cells and extra-cellular matrix) into a smaller geometry. This constrictive remodeling is analogous to wound contraction and fibrosis and can also lead to lumen encroachment. While much is known about the regulation of smooth muscle cell hyperplasia, little is known about the molecular regulation of artery wall remodeling and constriction. Our lab is studying the effects of various matrix components on tissue contraction. Specifically, we are studying the interaction between cells, collagen, and hyaluronic acid - a prominent component of the matrix secreted by smooth muscle cells as they repair the injured artery wall. It is unclear whether hyaluronan improves or impairs reorganization of collagen following injury. To address this question we are studying the injury response in atherosclerotic primates treated with peri-arterial hyaluronan and also the effects of genetic deletion of specific hyaluronan receptors in knockout mice and effects on the response to injury. The overarching goal is to identify molecular targets to block constrictive remodeling after arterial reconstruction as a means of preventing restenosis. Our lab is also collaborating with WFIRM on characterizing the in vivo responses of bioengineered blood vessels. Many parallels are likely in the healing of bioengineered arteries and the injury response in native arteries. By manipulating cells and scaffoldings used in constructing bioengineered blood vessels, we may be able to alter healing responses to improve vessel maturation.

Quick Reference

Institute for Regenerative Medicine

Phone 336-713-7293
Fax 336-713-7290

Location
Richard H. Dean Biomedical Building
391 Technology Way
Winston-Salem, NC 27101
Find A Doctor Ways to Give
Last Updated: 09-26-2014
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.