Aaron Goldstein, PhD
Aaron Goldstein, Ph.D., Associate Professor
Dr. Goldstein received a B.S. and Ph.D. degrees in Chemical Engineering at University of California Berkeley and Carnegie Mellon University, respectively, and was a post-doctoral research associate in the Department of Bioengineering at Rice University under the mentorship of Dr. Antonios Mikos. He has been a faculty member in the Department of Chemical Engineering at Virginia Polytechnic Institute and State University since 1999 and a core faculty member of the Virginia Tech/Wake Forest School of Biomedical Engineering and Sciences since its inception in 2003.
SYNOPSIS OF AREA OF INTEREST: Dr. Goldstein's research efforts have focused on the development of in vitro strategies to form materials for the repair of bone and ligament deficits. This work has included the synthesis and processing of biocompatible degradable polymers and the development of bioreactor strategies to stimulate differentiation of mesenchymal progenitor cells.
DETAILED AREA OF INTEREST: His research group has focused on two avenues of research toward the development of engineered bone and ligament tissues: biomaterial processing, and bioreactors.
Biomaterials processing: In conjunction with Dr. Scott Guelcher (Vanderbilt University) degradable elastomeric polyurethanes have been compression molded into porous foams and electrospun into fiber meshes for bone and ligament applications, respectively. The ability to use polymers with tunable chemistries and mechanical properties will permit the systematic examination of cell/biomaterial interactions on tissue development.
Bioreactors: In conjunction with Drs. George Christ and James Yoo cyclic stretch and perfusion bioreactor systems are being tested to stimulate differentiation of mesenchymal progenitor cells into ligament- and bone-like tissues, respectively. Concurrently, studies are being conducted to understand how mechanotransductive signaling pathways are modulated by dynamic mechanical stimulus.