Edward Kincaid, MD
Edward Kincaid, M.D., Assistant Professor
Dr. Edward Kincaid is a native of North Carolina and graduated from UNC-Chapel Hill with a degree in Chemistry. After working as an analytical chemist at the Research Triangle Institute, Dr. Kincaid entered the field of medicine and received his M.D. from the Bowman Gray School of Medicine in 1994. His training continued at Wake Forest Baptist Medical Center with completion of residencies in general and thoracic surgery. He joined the faculty there in 2002 with clinical interests in adult cardiac surgery. He is the director of minimally-invasive cardiac surgery.
SYNOPSIS OF AREA OF INTEREST: Multiple clinical research interests including stentless valve replacements, right ventricular performance, pharmacology, and bleeding. Basic research involves the development of tissue-engineered heart valves.
DETAILED AREA OF INTEREST: Currently available heart valve substitutes have many limitations including thrombogenicity and degeneration. In an ovine model, we are creating tissue-engineered heart valves from decellularized collagen-based porcine valves that have been repopulated with host smooth muscle and endothelial cells derived from progenitor cells obtained from peripheral blood. Implanted in the pulmonary position, we anticipate that these constructs will have acceptable hemodynamic profiles and contain appropriate cellular and extracellular components at early and longer-term analysis. Such components should improve thrombogenicity and durability and may allow for growth in the immature heart. The long-term goals of this study are to create a tissue-engineered valve suitable for routine use in humans. Specific aspects of the current project are designed to facilitate this translation: 1) use of easily-obtained peripheral blood as a source of progenitor cells, 2) use of widely available xenograft material for creation of a scaffold, 3) use of the sheep model because of anatomic and physiologic similarity to humans, and 4) creation of a valve that functions immediately and is highly resistant to thrombosis.