Kenneth L. Koch, MD
Kenneth L. Koch, M.D., Professor
Dr. Kenneth Koch is a Professor of Internal Medicine and Chief, Section on Gastroenterology at Wake Forest School of Medicine. He completed his undergraduate and medical school degrees at the University of Iowa, Internal Medicine training at Milton S. Hershey Medical Center of Pennsylvania State University, and fellowship in gastroenterology at the University of Florida.
Dr. Koch's clinical and research interests include the pathophysiology of nausea and vomiting, gastroparesis and gastric dysrhythmias. He has authored numerous original works, chapters, books and other contributions to the GI literature. Dr. Koch has been selected as one of the "Best Doctors in America" since 2001.
SYNOPSIS OF AREA OF INTEREST:
- Gastric neuromuscular function in the post prandial condition, including sensations of stomach fullness and satiety; and
- Gastric neuromuscular dysfunction as indicated by gastroparesis and gastric dysrhythmias, which are physiological conditions associated with nausea and vomiting.
DETAILED AREA OF INTEREST: What is nausea? This question has driven my area of research interest for over 20 years. Nausea is a debilitating symptom, whether it occurs in an environment of motion (ex., motion sickness) or during therapy (ex., chemotherapy-induced nausea and vomiting). This interest has led me to investigate the nausea of motion sickness, nausea and vomiting of first trimester of pregnancy, post-surgical and diabetic gastroparesis, and unexplained nausea. A technology we have used extensively to study the stomach non-invasively is the electrogastrogram, a recording of myoelectrical activity from the stomach. Healthy individuals are usually in a 3 cycle per minute rhythm; but during almost all types of nausea, the gastric rhythm becomes abnormal and is termed a tachygastria or bradygastria. We have described these dysrhythmias in a variety of nausea conditions.
We are part of a seven-center consortium sponsored by the NIH to investigate gastroparesis related to post-surgical, diabetic, and idiopathic gastroparesis. At Wake Forest our focus is diabetic gastroparesis. Industry-related research is presently focused on measuring gastric electrical activity with a catheter inserted into the stomach wall during endoscopy.
The GI Neurogastroenterology and Regenerative Medicine Program was established by Khalil Bitar, PhD, Professor, Institute of Regenerative Medicine, Sticht Center on Aging, Gastroenterology, and Physiology & Pharmacology, and me as a translational research effort to develop bioengineered tubular structures of GI smooth muscle, enteric neurons, and pacemaker cells as replacement organs for patients with motility disorders such as fecal incontinence and gastroparesis.