Baisong Lu, PhD
Baisong Lu, Ph.D., Assistant Professor
Dr. Baisong Lu was born and raised in Hunan, a southern Province of China. He received his Bachelor’s Degree in biology from Beijing Normal University in 1991. He attended graduate school at Chinese PLA Medical Institute in molecular genetics in the same year. Upon graduation, he accepted a research position with Beijing Institute of Biotechnology. Since 2000 he received postdoctoral training at Harvard Medical School (2000) and Baylor College of Medicine (2000-2003). Then he ran his own lab as an associate professor at Beijing Institute of Biotechnology from 2003 to 2005. Beginning in January 2006 he worked as a Research Associate at Baylor College of Medicine. Shortly after that he joined the Wake Forest Institute for Regenerative Medicine as an Instructor. In 2010, he was promoted to Assistant Professor. Dr. Lu is the author of more than thirty peer-reviewed papers and the inventor on a patent.
SYNOPSIS OF AREA OF INTEREST: Dr. Lu’s research interests include mitochondrial dysfunction in infertility and aging, and RNA-binding protein MEX3C controlling adiposity.
DETAILED AREA OF INTEREST:
1) Mitochondrial oxidative stress in reproduction and neurodegeneration: Dr. Lu is using the Immp1l mutant mouse model to study the role and the mechanism of mitochondrial dysfunction in infertility and age-related neurodegeneration. Immp1l mutant mice show excessive mitochondrial superoxide generation but almost normal mitochondrial ATP generation. These mice are infertile and develop age dependent neurodegeneration.
2) RNA-binding protein MEX3C in energy balance control: MEX3C is an RNA-binding protein conserved between mouse and human. We found that Mex3c mutant mice, in addition to showing retarded growth, have reduced adiposity resulting from increased energy expenditure. Partial restoring Mex3c expression in neurons of Mex3c mutant mice improved adiposity, suggesting the involvement of neuronal Mex3c in energy balance control. In vitro, MEX3C protein enhances FOS mRNA nuclear export, stability and translation. We are investigating whether regulating transsynaptic FOS is one of the mechanisms for Mex3c’s involvement in energy balance control.
Complete list of publications can be found at: