Military Applications

Body on a Chip

Wake Forest Institute for Regenerative Medicine is leading a unique $24 million federally funded project to develop a "body on a chip" that will be used to model the body's response to harmful chemical and biological agents and develop potential treatments. 

The project involves using human cells to create tiny organ-like structures that mimic the function of the heart, liver, lung and blood vessels. Placed on a 2-inch chip, these structures will be connected to a system of fluid channels and sensors to provide on-line monitoring of individual organs and the overall organ system.

The circulating blood substitute will keep the cells alive and can be used to introduce chemical or biologic agents, as well as potential therapies, into the system. Hollow channels will automatically guide the toxins or therapies that are being evaluated from one tissue to the next and sensors will measure real-time temperature, oxygen levels, PH and other factors.

While the idea of culturing 3-D human tissue on a chip is not new, this will be one of the first efforts to combine several organs in the same device to model the human response to chemical toxins or biologic agents.

Body on a Chip

 

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Institute for Regenerative Medicine

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Last Updated: 02-06-2014
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