Shay Soker, PhD

Soker 11-12 web

Shay Soker, Ph.D., Professor

Dr. Soker received his Bachelor’s Degree in Agriculture from the Hebrew University of Jerusalem in 1985. He received his Master’s Degree in Microbiology and Molecular Genetics from the Hebrew University of Jerusalem in 1987 and his PhD in Biology from the Technion-Israel Institute of Technology in 1993.

SYNOPSIS OF AREA OF INTEREST:

  1. Neovascularization of bioengineered tissues, including angiogenic gene transfer to enhance tissue function and cell therapy using vascular cells.

  2.  Identification and isolation of stem cells from different sources, including adult and fetal stem cells from amniotic fluid and placenta, and their directed differentiation to generate tissues in vitro and in vivo.

  3.  Tissue-derived extracellular matrices as scaffolds for whole organ bioengineering.

  4.  Bioengineering of ophthalmic tissues including the cornea.

  5.  Advanced tissue and cell imaging technologies in regenerative medicine application.

  6.  Vascular endothelial growth factor (VEGF) and its receptors; augmentation and suppression of VEGF activities by manipulation of VEGF receptors.

  7. Circulating endothelial progenitor cells in physiological and pathological angiogenesis.

DETAILED AREA OF INTEREST:

Dr. Soker has a particular interest in molecular and cellular biology. Dr. Soker applies his skill to integrate principles of vascular biology in regenerative medicine applications, to study the biology of stem and progenitors cells that are needed for tissue damage repair and regeneration, and to understand the biochemical nature of natural materials that can be used for tissue engineering.   

Because of his knowledge and interest in angiogenesis Dr. Soker developed programs in neo-vascularization of bioengineered tissues, including angiogenic gene transfer to enhance tissue function and cell therapy using vascular cells. His stem cell research focuses on the identification and isolation of stem cells from different sources, including adult and fetal stem cells from amniotic fluid and placenta, and their directed differentiation to generate tissues in vitro and in vivo. In parallel, Dr. Soker’s group is exploring tissue-derived extracellular matrices as scaffolds for whole organ bioengineering. He had published several manuscripts describing this technology for the engineering of organs and tissues including liver, kidney, pancreas, intestine, cornea and more. Dr. Soker is among the few researchers who are implementing advanced tissue and cell imaging technologies in regenerative medicine application. Some of Dr. Soker’s projects are now being discussed with industry collaborators in order to create new regenerative medicine product. An example is a cornea scaffold that is used to deliver corneal endothelial cells to patients with inheritable eye disease or older individuals who are in danger of losing vision.  

 

Quick Reference

Institute for Regenerative Medicine

Phone 336-713-7293
Fax 336-713-7290

Location
Richard H. Dean Biomedical Building
391 Technology Way
Winston-Salem, NC 27101
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Last Updated: 10-13-2014
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