J. Koudy Williams, DVM
J. Koudy Williams, DVM, Professor
Dr. Williams graduated from Iowa State University of Science and Technology with a BS in 1976, followed by a DVM from the same university in 1983. He has been at Wake Forest Baptist Medical Center for 18 years. His interests are in teaching, research on the effects of sex hormones on chronic disease, and clinical work with primates.
SYNOPSIS OF AREA OF INTEREST: In teaching, Dr. Williams focuses on vascular disease, atherosclerosis, physiology, cardiology, hypertension, pathology, and growth factors. In research his focus is on the role of atherosclerosis and ovarian hormones on endothelium-mediated vascular responses, vasospasm, cardiovascular diseases, and women's health. In the clinical arena, Dr. Williams' specialties are medical primatology and veterinary cardiology.
DETAILED AREA OF INTEREST: Over the years, the purpose of his research has been to determine the influence of certain atherosclerosis risk factors and hormones on vascular reactivity. Using cynomolgus monkeys as a nonhuman primate model of atherosclerosis in human beings, his studies have focused on two primary areas. The first is the influence of atherosclerosis on endothelial dysfunction as related to vasomotion, demonstrating that atherosclerosis damages endothelial cells, resulting in altered vasomotion and vasospasm. The second is the pathobiology of restenosis after angioplasty in non human primates. Studies in his laboratory focus on the effects of mammalian and plant estrogens on restenosis and the potential role of gene transfer in prevention of restenosis in a monkey model of diet-induced atherosclerosis. At the Institute, Dr. Williams currently focuses his research on regenerative medicine approaches to the prevention and treatment of coronary heart disease. Specifically, his research involves the use of amniotic and bone marrow-derived stem and progenitor cells for the construction and use of bioengineered vessels and stem cell-based approaches to stabilize and reverse atherosclerotic lesions. The research primarily involves the use of nonhuman primates as models of diet-induced coronary artery atherosclerosis. He is involved in several other projects including a cell-based therapy for the treatment of diabetes, muscular dystrophy and cancer. His clinical interests involve the care and treatment of nonhuman primates. He travels to Indonesia as a veterinary consultant and as a visiting clinician and scientist for the conservation of several nonhuman primate species.