TanYa Gwathmey-Williams

TanYa Gwathmey-Williams

TanYa M. Gwathmey-Williams, MS, PhD
Research Fellow

Education:  BS – Molecular Biology Hampton University, Hampton, V.A. (1995)
MS – Reproductive Biology and Endocrinology Jones Institute for Reproductive Medicine
Eastern Virginia Medical School, Norfolk, V.A. (1999)
PhD – Reproductive Physiology Cornell University, Ithaca, N.Y. (2006)
Laboratory Department: Hypertension and Vascular Research Center
Email: tgwathme@wakehealth.edu
Advisor: Dr. Mark Chappell

Current Research:  My research is part of a program project grant entitled, “Prenatal Events, Postnatal Consequences”.  This work evaluates the role of maternal programming on the regulation of renal function and blood pressure by examining the long-term effects of antenatal synthetic glucocorticoid exposure on the development of hypertension and renal injury in adults.  My focus is to evaluate the effects of prenatal steroid exposure on the intra-renal Renin-Angiotensin System (RAS) at different stages of development.

Publications:

Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochem Biophys Res Commun. 2009 Jun 26;384(2):149-54.

Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1484-93.

Gwathmey TM, Ignotz GG, Mueller J, Manjunath P, and Suarez SS.  Bovine seminal plasma proteins provide protective effects to sperm in vitro. Biol Reprod. 2006 Oct; 75(4):501-7. Epub 2006 Jun 21.

Gwathmey TM.  Forming the oviductal sperm reservoir: mechanism and function.  Doctoral Dissertation, Cornell University, January  2006.

Gwathmey TM, Ignotz GG, Suarez SS.  PDC-109 (BSP A1/A2) promotes binding of bovine sperm to oviductal epithelium in vitro, and may be responsible for formation of the oviductal sperm reservoir. Biol Reprod. 2003 Sep; 69(3):809-15. Epub 2003 May 14.

Ignotz GG, Lo M, Perez CL, Gwathmey TM, Suarez SS. Characterization of a fucose-binding protein from bull sperm and seminal plasma that may be responsible for formation of the oviductal sperm reservoir. Biol Reprod 2001; 64:1806-11.

Gwathmey T, Blackmore PF, Mahony MC. Progesterone - induced calcium influx in Cynomolgus monkey spermatozoa.   J Androl 2000; 21(4): 534-540.

Gwathmey T. Phosphorylation of protein residues involved in hyperactivated motility of macaque sperm.  The Jones Institute for Reproductive Medicine, Dept. of OB/GYN, and Dept. of Biological Sciences, Hampton University. Master’s Thesis. – August 1999.

Mahony MC, Gwathmey T. Protein tyrosine phosphorylation during hyperactivated motility of Cynomolgus monkey (Macaca fascicularis) spermatozoa. Biol Repro 1999; 60: 1239-1243.

Conference Proceedings and Abstracts:

Gwathmey TM
, Ignotz GG, Manjunath P, Suarez SS. Bovine seminal plasma proteins A3 and 30kDa share functional roles with PDC-109 to mediate sperm binding to oviductal epithelium. (Presented at the American Society for Reproductive Medicine, Philadelphia, PA)

Gwathmey TM, Croxatto HB, Ortiz ME, Salvatierra AM, Llados C, and Suarez SS.  Interactions of human sperm with cervical and oviductal epithelium: implications for reservoir formation. (Presented at the 2003 Meeting of the Society for the Study of Reproduction, Cincinnati, Ohio, Abstract No. 371)

Gwathmey TM, Ignotz GG, Suarez SS. PDC-109 enables epididymal bull sperm to bind oviductal epithelium. (Presented at the 2002 Annual Meeting of the American Society of Andrology, Seattle, Washington)

Gwathmey TM, Ignotz GG, Suarez SS.  The role of a fucose-binding protein in sperm binding to bovine oviductal epithelium. (Presented at the International Society of Andrology Meeting, Montreal, Quebec, June 2001)

Gwathmey TM, Ignotz GG, Suarez SS.  PDC-109 mediates the binding of bovine sperm to oviductal epithelium. Biol Reprod 2001; 64: 112 Suppl. 1

Ignotz GG, Lo MC, Perez CL, Gwathmey TM, Surarez SS.  Identification of a fucose-binding protein from bull sperm and seminal plasma which participates in formation of the oviductal sperm reservoir.  Biol Reprod 2001; 64: 329  Suppl 1

Gwathmey T, Blackmore PF, Mahony MC.  Progesterone-induced calcium influx in Cynomolgus monkey spermatozoa.  Biol Reprod. 1998; 58: 20  Suppl. 1

Mahony MC and Gwathmey T.  Stimulation of protein tyrosine phosphorylation during capacitation-dependent hyperactivated motility of macaque spermatozoa.  Biol Reprod Suppl 1998

Gwathmey T, Gosh K, Morin F.  The effects of nitric oxide synthase on the persistent pulmonary hypertension of fetal lambs.  SUNY at Buffalo School of Medicine and Biomedical Sciences. 1993. (Published: The National Conference for Undergraduate Research Catalogue, 1994)

Gwathmey T, Witko-Sarsat V, Eissa N.T.  The role of nitric-oxide in hypoxia – induced lung injury in rats.   NHLBI, National Institutes of Health.  1994.

Contributed Talks:

Proteins of seminal plasma provide protective effects to sperm in vitro, to maintain motility.  60th Annual Meeting of the American Society for Reproductive Medicine, Philadelphia, PA

Bovine seminal plasma proteins A3 and 30kDa share a functional role with PDC-109 to mediate sperm binding to oviductal epithelium.  37th Annual Meeting of the Society for the Study of Reproduction, Vancouver, British Columbia, Canada

Forming the Oviductal Sperm Reservoir in Mammals. 2004 Northeast Regional Conference onReproduction, Cornell University, Ithaca NY

Session Chair: Genetic and environmental factors that disrupt reproductive function. 29th Annual Meeting of the American Society of Andrology, Baltimore, Maryland

Interactions of human sperm with cervical and oviductal epithelium: implications for reservoir formation.  36th Annual Meeting of the Society for the Study of Reproduction, Cincinnati, Ohio

PDC-109 enables epididymal bull sperm to bind oviductal epithelium 27th Annual Meeting of the American Society of Andrology, Seattle, Washington

PDC-109 mediates the binding of bovine sperm to oviductal epithelium 34th Annual Meeting of the Society for the Study of Reproduction, Ottawa, Ontario, Canada

Session Chair: Regulation of sperm function 34th Annual Meeting of the Society for the Study of Reproduction, Ottawa, Ontario, Canada

The role of a fucose-binding protein in sperm binding to bovine oviductal epithelium 7th International Congress of Andrology, Montreal, Quebec, Canada

Progesterone-induced calcium influx in Cynomolgus monkey spermatozoa 31st Annual Meeting of the Society for the Study of Reproduction, College Station, Texas

Protein tyrosine phosphorylation during hyperactivated motility of Cynomolgus monkey (Macaca fascicularis) spermatozoa.  23rd Annual Meeting of the American Society of Andrology, Long Beach,California

The effects of nitric oxide synthase on the persistent pulmonary hypertension of fetal lambs.  8th Annual Meeting of the National Conference of Undergraduate Research, Kalamazoo, Michigan

Honors and Awards:

Society for Male Reproduction and Urology Traveling Scholars Award – 60th Annual Meeting of the American Society of Reproductive Medicine, Philadelphia, PA – October 2004
NIH/NICHD R13 Travel Grant Recipient (2004)
Federation of American Societies for Experimental Biology (FASEB) – Presenter Travel Award, Society for the Study of Reproduction, Cincinnati, Ohio (2003)
Mario Einaudi Fellowship for Traveling Scholars, Santiago, Chile (2002)
Outstanding Teaching Assistant Award, Department of Biomedical Sciences, Cornell University, Ithaca NY (2002)Female Trainee Award for Outstanding Research - International Society of Andrology Montreal, Quebec, Canada (2001)
Federation of American Societies for Experimental Biology (FASEB) – Oral Presenter Travel Award Ottawa, Canada (2001)
Dean’s List for Recognition of Outstanding Academic Achievement, Hampton University, Hampton, VA (1999)
Beta Kappa Chi Scientific Honor Society Award for Academic Achievement (1995)
Howard Hughes Medical Institute Scholarship (1991-1995)

 

Quick Reference

Hypertension & Vascular Research Center
Debra I. Diz, PhD
Program Director

ddiz@wakehealth.edu

Samantha Statham

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