Cancer Faculty
The major focus of investigators in this area is the use of genetic and molecular approaches to study the underlying mechanisms of cancer and factors that contribute to tumor progression. Examples include identification of cancer susceptibility genes, genetic variation in tumor formation, DNA damage and repair pathways, and carcinogens.
Steve Akman DNA damage, mutagenesis, and genomic instability. Faculty Profile & Publications / Lab Page
Yong Chen Tumor suppressor genes; apoptosis; cell-cycle regulation; prostate cancer. Faculty Profile & Publications / Lab Page
Zheng Cui Lipid signaling in apoptosis and carcinogenesis. Faculty Profile & Publications
Waldemar Debinski Focus of the identification of molecular markers/targets that are specific to brain tumors. Faculty Profile & Publications
Cristina Furdui Research in our laboratory is directed towards applying advanced systems biology methodologies to i] investigate the timing of signaling events in the propagation of receptor tyrosine kinases signaling, ii] quantify the effect of oncogenic mutations or oxidation on the re-wiring of these signaling networks under pathogenic conditions, iii] apply clinical proteomics to identify molecular predictors of response to different cancer therapies in an effort to create personalized therapies; and iv] interface time-resolved mass spectrometry with microfluidics technology and develop new nanokinetics platforms for quantitative monitoring of rapid enzyme kinetics/drug screening assays to further our understanding of potential drug targets at molecular level. Faculty Profile & Publications / Research Description
William Gmeiner My lab is interested in understanding how efficacious anti-cancer drugs cause cancer cell death and in designing new drugs and novel drug delivery strategies. Faculty Profile & Publications / Lab Page
Steven Kridel Proteases and Cancer: Proteases play pivotal roles in the progression of cancer. Fatty Acid Synthase and prostate cancer: Fatty acid synthase (FAS) has been established as a biomarker and prognostic indicator for prostate cancer. Faculty Profile & Publications / Lab Page
Mark Miller Molecular pathogenesis and chemoprevention of lung cancer. Faculty Profile & Publications / Lab Page
Akiva Mintz Utilizing multimodality molecular imaging to personalize biomarker targeted therapies by non-invasively detecting and quantifying the targeted tumor biomarkers/pathways. Faculty Profile & Publications
Timothy Pardee My research focus is directed at understanding how Acute Myeloid Leukemia cells resist chemotherapy with the hope of using this information to design clinical trials and improve outcomes for patients with this devastating disease. Faculty Profile & Publications/ Lab Page
Fred Perrino Molecular mechanisms of mutagenesis during DNA replication in animal cells; use of in vitro model systems. Faculty Profile & Publications / Lab Page
Suzy Torti Regulation of iron metabolism in normal and transformed cells. Faculty Profile & Publications / Lab Page
Alan Townsend Mechanisms of resistance to cytotoxic and mutagenic agents; enzymes of glutathione metabolism; chemoprevention of cancer; oxidative stress and antioxidant defenses. Faculty Profile & Publications / Research Interests
Yuh-Hwa Wang Human fragile sites, DNA rearrangement, oncogenesis, trinucleotide repeat expansion diseases, chromatin structure. Faculty Profile & Publications / Research Interests
John Wilkinson Apoptosis regulation in the pathogenesis of cancer and other human diseases. Faculty Profile & Publications/ Research Interests