Cancer Faculty

The major focus of investigators in this area is the use of genetic and molecular approaches to study the underlying mechanisms of cancer and factors that contribute to tumor progression. Examples include identification of cancer susceptibility genes, genetic variation in tumor formation, DNA damage and repair pathways, and carcinogens.

Yong Chen Tumor suppressor genes; apoptosis; cell-cycle regulation; prostate cancer. Faculty Profile & PublicationsLab Page

Zheng Cui Lipid signaling in apoptosis and carcinogenesis. Faculty Profile & Publications

Waldemar Debinski Focus of the identification of molecular markers/targets that are specific to brain tumors. Faculty Profile & Publications

Cristina Furdui  Research in our laboratory is directed towards applying advanced systems biology methodologies to i] investigate the timing of signaling events in the propagation of receptor tyrosine kinases signaling, ii] quantify the effect of oncogenic mutations or oxidation on the re-wiring of these signaling networks under pathogenic conditions, iii] apply clinical proteomics to identify molecular predictors of response to different  cancer therapies in an effort to create personalized therapies; and iv] interface time-resolved mass spectrometry with microfluidics technology and develop new nanokinetics platforms for quantitative monitoring of rapid enzyme kinetics/drug screening assays to further our understanding of potential drug targets at molecular level. Faculty Profile & Publications / Research Description

William Gmeiner My lab is interested in understanding how efficacious anti-cancer drugs cause cancer cell death and in designing new drugs and novel drug delivery strategies. Faculty Profile & Publications / Lab Page

Steven Kridel Proteases and Cancer: Proteases play pivotal roles in the progression of cancer. Fatty Acid Synthase and prostate cancer: Fatty acid synthase (FAS) has been established as a biomarker and prognostic indicator for prostate cancer. Faculty Profile & Publications / Lab Page

Akiva Mintz Utilizing multimodality molecular imaging to personalize biomarker targeted therapies by non-invasively detecting and quantifying the targeted tumor biomarkers/pathways. Faculty Profile & Publications

Timothy Pardee My research focus is directed at understanding how Acute Myeloid Leukemia cells resist chemotherapy with the hope of using this information to design clinical trials and improve outcomes for patients with this devastating disease. Faculty Profile & Publications/ Lab Page

Fred Perrino Molecular mechanisms of mutagenesis during DNA replication in animal cells; use of in vitro model systems. Faculty Profile & PublicationsLab Page

Alan Townsend Mechanisms of resistance to cytotoxic and mutagenic agents; enzymes of glutathione metabolism; chemoprevention of cancer; oxidative stress and antioxidant defenses. Faculty Profile & PublicationsResearch Interests 

Quick Reference

Telephone 336-713-7005

Dr. Timothy Howard
Program Director

tdhoward@wakehealth.edu

Dr. Nicholette Allred
Graduate Students Recruiting Director

nallred@wakehealth.edu

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