Structural Biology Faculty

Investigators in structural biology study the molecular structures and physical properties of proteins, nucleic acids and their complexes. The tools of molecular biology are used to synthesize proteins in large quantities suitable for physical analysis by X-ray crystallography, mass spectrometry, enzymology, and a variety of biophysical methods such as light scattering and sedimentation.

Rebecca Alexander Understanding protein-nucleic acid interactions at the molecular level. Faculty Profile / Publications / Research Details / Lab Page

Al Claiborne Structural and mechanistic studies of flavoproteins in streptococcal oxygen metabolism; catalytic functions of flavin coenzymes. Faculty Profile & PublicationsLab Page

Jacquelyn Fetrow Computational analysis of functional sites in proteins; development of methods to model biological networks from experimental time course data; and analysis of molecular dynamics and motion in proteins. Faculty Profile / Fetrow Research Group

Roy Hantgan Molecular mechanisms of blood coagulation and fibrinolysis; conformation of proteins in solution. Faculty Profile & Publications / Lab Page

Tom Hollis X-ray crystallographic studies of DNA repair proteins and Fanconi anemia-associated proteins. Faculty Profile & PublicationsLab Page

David Horita Nuclear magnetic resonance spectroscopy/structural biology of protein-lipid interactions. Faculty Profile & Publications / Lab Page

Daniel Kim-Shapiro Nitrogen oxide signaling in hemoglobin and other heme proteins in normal physiology, disease and therapeutics using various spectroscopies including EPR, light scattering, and time-resolved absorption. Faculty Profile & Publications / Research Interests

Todd Lowther X-ray crystallographic and biochemical analyses of enzymes that repair the oxidative damage to free and protein-incorporated methionine. Faculty Profile & PublicationsLab Page

Derek Parsonage Enzymology of bacterial enzymes involved in defending against oxidative stress: enzymes that utilize flavin and cysteine residues at the catalytic site. Faculty Profile & Publications /Lab Page

Leslie Poole Mechanistic enzymology of bacterial enzymes involved in protection against oxidative stress; novel roles of catalytic cysteine residues. Faculty Profile & PublicationsLab Page

Quick Reference

Telephone 336-716-4674

Dr. Mark Lively
Program Director

mlively@wakehealth.edu

Dr. Timothy Howard
Graduate Students Recruiting Director

tdhoward@wakehealth.edu

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