Jerry Angdisen, M.S.
National Cancer Institute, Cell and Cancer Biology Branch Rockville, MD
M.S., Molecular Medicine and Translational Science Graduate Program, Dec. 2007
Wake Forest University School of Arts and Sciences
BS, Biology, 1992 - 1998
University of the District of Columbia
My research while in the Molecular Medicine program involved understanding how fetal defects in fatty acid oxidation can cause liver disease in a pregnant mother. Research from Dr. Ibdah's laboratory and others have documented that pregnant women develop liver disease while carrying fetuses that are deficient in a specific fatty acid oxidation enzyme, long chain 3-hydroxyacyl Co-A dehydrogenase (LCHAD). Although the association between this fetal defect and liver disease in the pregnant mother has been well established, little is known about the molecular mechanisms underlying this fetal-maternal interaction. I generated a mouse model for this human disease in order to gain insight into the underlying molecular mechanisms of this fascinating fetal-maternal interaction. Unlocking and understanding the molecular mechanisms underlying this disorder may prevent the potentially fatal neonatal and maternal outcome of this disorder.
Pandey J, Umphress SM, Kang Y, Angdisen J, Naumova A, Mercer KL, Jacks T, Jakowlew SB. Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency. Carcinogenesis. 2007 Dec;28(12):2589-96.
Ibdah JA, Perlegas P, Zhao Y, Angdisen J, Borgerink H, Shadoan MK, Wagner JD, Matern D, Rinaldo P, Cline JM. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology. 2005 May;128(5):1381-90.
Angdisen J, Moore VD, Cline JM, Payne RM, Ibdah JA. Mitochondrial trifunctional protein defects: molecular basis and novel therapeutic approaches. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Mar;5(1):27-40. Review.
Ozbun LL, Martinez A, Angdisen J, Umphress S, Kang Y, Wang M, You M, Jakowlew SB. Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development. Dev Dyn. 2003 Mar;226(3):491-511.
Kang Y, Ozbun LL, Angdisen J, Moody TW, Prentice M, Diwan BA, Jakowlew SB. Altered expression of G1/S regulatory genes occurs early and frequently in lung carcinogenesis in transforming growth factor-beta1 heterozygous mice. Carcinogenesis. 2002 Jul;23(7):1217-27.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine