Jerry Angdisen, M.S.

angdisen

Research Associate
NIH
National Cancer Institute, Cell and Cancer Biology Branch Rockville, MD


Education:

M.S., Molecular Medicine, 2007
Wake Forest University
School of Medicine
Winston-Salem, NC

BS, Biology, 1992 - 1998
University of the District of Columbia
Washington, DC


Current Research:

My research while in the Molecular Medicine program involved understanding how fetal defects in fatty acid oxidation can cause liver disease in a pregnant mother. Research from Dr. Ibdah's laboratory and others have documented that pregnant women develop liver disease while carrying fetuses that are deficient in a specific fatty acid oxidation enzyme, long chain 3-hydroxyacyl Co-A dehydrogenase (LCHAD). Although the association between this fetal defect and liver disease in the pregnant mother has been well established, little is known about the molecular mechanisms underlying this fetal-maternal interaction. I generated a mouse model for this human disease in order to gain insight into the underlying molecular mechanisms of this fascinating fetal-maternal interaction. Unlocking and understanding the molecular mechanisms underlying this disorder may prevent the potentially fatal neonatal and maternal outcome of this disorder.

Publications:

Pandey J, Umphress SM, Kang Y, Angdisen J, Naumova A, Mercer KL, Jacks T, Jakowlew SB. Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency. Carcinogenesis. 2007 Dec;28(12):2589-96.

Ibdah JA, Perlegas P, Zhao Y, Angdisen J, Borgerink H, Shadoan MK, Wagner JD, Matern D, Rinaldo P, Cline JM. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology. 2005 May;128(5):1381-90.

Angdisen J, Moore VD, Cline JM, Payne RM, Ibdah JA. Mitochondrial trifunctional protein defects: molecular basis and novel therapeutic approaches. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Mar;5(1):27-40. Review.

Ozbun LL, Martinez A, Angdisen J, Umphress S, Kang Y, Wang M, You M, Jakowlew SB. Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development. Dev Dyn. 2003 Mar;226(3):491-511.

Kang Y, Ozbun LL, Angdisen J, Moody TW, Prentice M, Diwan BA, Jakowlew SB. Altered expression of G1/S regulatory genes occurs early and frequently in lung carcinogenesis in transforming growth factor-beta1 heterozygous mice. Carcinogenesis. 2002 Jul;23(7):1217-27.

For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine

Quick Reference

Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare

336-713-4259

kcollare@wakehealth.edu

Find A Doctor Ways to Give
Last Updated: 12-03-2014
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.