Jeannette Bensen, M.S, Ph.D.

Assistant Professor, Epidemiology
Co-Director, Prostate Cancer Consortium
Lineberger Comprehensive Cancer Center
University of North Carolina, Chapel Hill


Email:   jbensen@med.unc.edu

Education:

Bowman Gray School of Medicine-Wake Forest University, Post-doc Fellowship, 2002-2003
Bowman Gray School of Medicine-Wake Forest University, Ph.D., 2002
University of Pittsburgh, M.S., 1985
SUNY College of Fredonia, BS, 1981

Research Interests:

My main research interest is to investigate the role of inflammation in complex disease (ex. cardiovascular disease, cancer) in well-characterized clinical or population-based sample groups with the goal being identification of risk groups for targeted intervention strategies or altered treatment methods. My research will continue to focus on genetic variation in inflammatory genes, in particular single nucleotide polymorphisms (SNP) and haplotype analysis, and gene-gene and gene-environment interaction in multiethnic epidemiologic studies. Additional interests include utilization of public genomic databases and software for genetic data analysis, as well as translational research with a focus on regulatory DNA sequence motifs and protein expression.

Publications:

Millikan RC, Newman B, Tse C-K, Moorman P, Smith LV, Labbok M, Geradts J, Bensen JT, Jackson S, Nyante S, Livasy C, Carey L, Perou CM Epidemiology of basal-like breast cancer. Breast Cancer Res Treat. 2007 Jun 20; [Epub ahead of print].

Gaudet MM, Gammon MD, Bensen JT, Sagiv SK, Shantakumar S, Teitelbaum SL, Eng SM, Neugut AI, Santella RM, Weston A. Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York. Breast Cancer Res Treat 2007; [in press].

Schroeder JC*, Bensen JT*, Su J, Mishel M, Ivanova A, Godley P, Smith G, Fontham E, Mohler J. (2006). The North Carolina – Louisiana Prostate Cancer Project (PCaP): Methods and design of a multidisciplinary population-based cohort study of racial differences in prostate cancer outcomes. Prostate. 66(11):1162-76. [*First authorship shared by Schroeder and Bensen]

Gaudet MM, Bensen JT, Olshan AF, Schroeder J, Terry MB, Eng SM, Teitelbaum SL, Britton JA, Lehman TA, Neugut AI, Ambrosone CB, Santella RM, Gammon MD. (2006). Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York. Breast Cancer Res Treat. 99(2):235-40.

Gaudet MM, Gammon MD, Santella RM, Britton JA, Teitelbaum SL, Eng SM, Terry MB, Bensen JT, Schroeder J, Olshan AF, Neuget AI, Ambrosone CB. (2005). MnSOD Val-9Ala Genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York. Cancer Causes Control. 16:1225-1234.

Sun J., Hedelin M., Zheng S.L., Adami H. O., Bensen J., Augustsson-Balter K., Chang B., Adolfsson J., Adams T., Turner A., Meyers D.A., Isaacs W.B., Xu J., Gronberg H. (2004). Interleukin-6 sequence variants are not associated with prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 13(10): 1677-9.

Zheng, S.L., Augustsson-Balter, K., Chang, B., Hedelin, M., Li, L., Adami, H.O., Bensen, J.T., Li, G., Johnasson, J.E., Turner, A.R., Adams, T.S., Meyers, D.A., Issacs, W.B., Xu, J., Gronberg, H. (2004). Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. Cancer Research 64(8):2918-22.

Bensen, J.T., Hsu, F-C., Brown, W.M., Sutton, B.S., Norris, J.M., Tracy, R.P., Jenny, N.S., Saad, M.F., Haffner, S.M., Bowden D.W., and Langefeld, C.D. (2004). Association analysis of the plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G polymorphism in Hispanics and African Americans: The IRAS Family Study. Human Heredity. 57(3):128-37.

Lindmark, F., Zheng, S., Wiklund, F., Bensen, J.T., Balter, K.A., Chan, B., Hedelin, M., Clark, J., Stattin, P., Meyers, D.A., Adami, H., Issacs, W.B., Gronberg, H., and Xu, J. (2004). The H6D polymorphism in the macrophage inhibitory cytokine gene 1 is associated with prostate cancer. J Natl Cancer Inst. 96(16):1248-54.

Hart, P.S., Wright, J.T., Savage, M., Kang, G., Bensen, J.T., Gorry, M.C., Hart, T.C. (2003). Exclusion of candidate genes in two families with autosomal dominant hypocalcified amelogenesis imperfecta. European Journal of Oral Sciences. 111(4):326-31.

Bensen, J.T., Langefeld, C.D., Hawkins, G.A., Green L.E., Mychaleckyj, J.C., Brewer, C.S., Kiger, D.S., Binford, S.M., Colicigno, C.J., Allred, D.C., Freedman, B.I., and Bowden, D.W. (2003). Nucleotide variation, haplotype structure and association of the human interleukin-1 gene cluster with end stage renal disease. Genomics. 82:194-217.

Bensen, J.T., Lange, L.A., Langefeld, C.D., Chang, B-L., Bleecker, E.R., Meyers, D.A., Xu, J. (2003). Exploring pleiotropy using principal components. BMC Genet. 2003, 4(Suppl 1):S53.

Bensen, J.T., Li, L., Langefeld, C.D., McCall, C.E., Cousart, S., Dryman, B.N., Freedman, B.I., and Bowden, D.W. (2003). Association of an IL1A 3’UTR Polymorphism with end stage renal disease and IL1a expression. Kidney International 63:1211-1219.

Bensen, J.T., Dawson, P.A., Mychaleckyj, J.C. and Bowden, D.W. (2001). Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. Journal of Interferon and Cytokine Research 21:899-904.

Fossey, S.C., Mychaleckyj, J.C., Pendleton, J.K., Snyder, J.R., Bensen, J.T., Hirakawa, S., Rich, S.S., Freedman, B.I. and Bowden, D.W. (2001). A high resolution 6.0 transcript map of the Type 2 diabetes susceptibility region on human chromosome 20. Genomics 76:45-57.

Williams R.R., Hunt S.C., Heiss, G., Province, M.A., Bensen J.T., Higgins, M., Chamberlain R.M., Ware, J. and Hopkins, P.N. (2001). Usefulness of cardiovascular family history data for population-based preventive medicine and medical research (the Health Family Tree Study and the NHLBI family Heart Study). Am J Cardiol. 87(2): 129-35.

For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.

 

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