Amanda Wibley Brown, PhD
Fellow, Physiology and Pharmacology Department
Wake Forest Health Sciences
Molecular Medicine and Translational Science, PhD, 2005- 2011
Wake Forest University School of Medicine
Ohio Wesleyan University, B.A. 2005
Majors: Microbiology and Genetics
Advisor: John S. Parks, Ph.D.: Pathology (Lipid Sciences)
Understanding the molecular mechanisms by which omega-3 fatty acid enriched oil, derived from Echium plantagineum, reduces plasma triglyceride concentrations and whether supplementation with echium oil will reduce atherosclerosis and arterial inflammation to a degree similar to that observed with fish oil. My research is aimed at how this botanical oil affects the activation state of macrophages elicited from mice fed supplementation diets and whether supplementation will lead to changes in expression of genes involved in inflammation as has been evidenced in fish oil studies.
Academic and Professional Honors:
2001-2002 Franklin B. Walter Award, one senior from each county in Ohio recognized by the OESCA
2001-2002 Sam Walton Community Scholarship
2001-2005 Leland F. and Helen Schubert Honors Program, Ohio Wesleyan University
2001-2005 Ohio Wesleyan University Trustee Scholarship covering three-quarters of the cost of tuition
2004-2005 Member of the American Society of Plant Biologists
2005 Graduated with Honors, Cum Laude, Ohio Wesleyan University
2005 Esther Carpenter Award for a senior female who has shown exemplary academic and research achievement in the Department of Botany-Microbiology, Ohio Wesleyan University
2005-2008 Graduate Fellowship Award, Wake Forest School of Medicine
2008-Present Student Member of the American Heart Association
2008-Present Ruth L. Kirschstein National Research Service Award
Mulya A, Brown AL, Chung SK, Seo J, Gebre AK, Boudyguina E, Shelness GS, Parks JS. Apolipoprotein M (apoM) expression increases the size of nascent pre-beta (pre-ß) HDL formed by ATP Binding Cassette Transporter A1 (ABCA1). Journal of Lipid Research [In revision]
Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Brown AL, Shah R, Davis M, Kelley K, Wilson M, Parks JS, Rudel LL.
Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 (SCD1) Inhibition Prevents The Metabolic Syndrome and Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology [In revision]
Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL.
Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation. 2008 Sep 30;118(14):1467-75.
Brown AL, Zhu XW, Wilson MD, Alexander-Miller M, Parks JS. Echium Oil Promotes Phenotypic Shifting in the Macrophage Lineage. Arteriosclerosis, Thrombosis, and Vascular Biology 29(7): E24 JUL 2009
Wibley AL, Beauchamp N, Wilson MD, Alexander-Miller M, Parks JS.
Echium Oil Modifies Macrophage Phenotypic Switching. NCCAM Botanical Center Directors’ Meeting, MAY 2008
Brown, JM Chung SK, Alger HM, Sawyer JK, Degirolamo C, Nguyen T, Zhu XW, Duong MN, Wibley AL, Davis MA, Kelley K, Wilson MD, Parks JS, Rudel LL. Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 28(6): E93 JUN 2008
Mulya A, Wilbley A, Chung SK, Gebre AK, Shelness GS, Parks JS. Impact of apolipoprotein M expression on pre-beta HDL formation by ATP binding cassette transporter A1 (ABCA1). Arteriosclerosis Thrombosis and Vascular Biology 27(6): E36 JUN 2007
Polter A, Wibley A, Mullen JL, Wolverton C. Gravitropism in akt1-1 roots lacks a significant DEZ contribution. American Society Plant Biologists P50: Abs# 415 JUL 2004