Amanda Wibley Brown, PhD

Amanda Brown

Fellow, Physiology and Pharmacology Department
Wake Forest Health Sciences
Winston-Salem, NC

Email:amabrown@wakehealth.edu

Education:
Molecular Medicine and Translational Science, PhD, 2005- 2011
Wake Forest University School of Medicine
Winston-Salem NC

Ohio Wesleyan University, B.A. 2005
Majors: Microbiology and Genetics
Minor: Chemistry

Advisor: John S. Parks, Ph.D.: Pathology (Lipid Sciences) 

Current Research:

Understanding the molecular mechanisms by which omega-3 fatty acid enriched oil, derived from Echium plantagineum, reduces plasma triglyceride concentrations and whether supplementation with echium oil will reduce atherosclerosis and arterial inflammation to a degree similar to that observed with fish oil.  My research is aimed at how this botanical oil affects the activation state of macrophages elicited from mice fed supplementation diets and whether supplementation will lead to changes in expression of genes involved in inflammation as has been evidenced in fish oil studies.

Academic and Professional Honors:

2001-2002 Franklin B. Walter Award, one senior from each county in Ohio recognized by the OESCA

2001-2002  Sam Walton Community Scholarship

2001-2005 Leland F. and Helen Schubert Honors Program, Ohio Wesleyan University

2001-2005 Ohio Wesleyan University Trustee Scholarship covering three-quarters of the cost of tuition

2004-2005  Member of the American Society of Plant Biologists

2005   Graduated with Honors, Cum Laude, Ohio Wesleyan University

2005 Esther Carpenter Award for a senior female who has shown exemplary academic and research achievement in the Department of Botany-Microbiology, Ohio Wesleyan University

2005-2008 Graduate Fellowship Award, Wake Forest School of Medicine

2008-Present   Student Member of the American Heart Association

2008-Present  Ruth L. Kirschstein National Research Service Award

Publications:

Journal Articles: 

Mulya A, Brown AL, Chung SK, Seo J, Gebre AK, Boudyguina E, Shelness GS, Parks JS.  Apolipoprotein M (apoM) expression increases the size of nascent pre-beta (pre-ß) HDL formed by ATP Binding Cassette Transporter A1 (ABCA1). Journal of Lipid Research [In revision]

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Brown AL, Shah R, Davis M, Kelley K, Wilson M, Parks JS, Rudel LL.
Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 (SCD1) Inhibition Prevents The Metabolic Syndrome and Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology [In revision]

Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL.
Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation. 2008 Sep 30;118(14):1467-75.

Abstracts: 

Brown AL, Zhu XW, Wilson MD, Alexander-Miller  M, Parks JS. Echium Oil Promotes Phenotypic Shifting in the Macrophage Lineage. Arteriosclerosis, Thrombosis, and Vascular Biology 29(7): E24 JUL  2009

Wibley AL, Beauchamp N, Wilson MD, Alexander-Miller  M, Parks JS.
Echium Oil Modifies Macrophage Phenotypic Switching. NCCAM Botanical Center Directors’ Meeting, MAY 2008

Brown, JM Chung SK, Alger HM, Sawyer JK, Degirolamo C, Nguyen T, Zhu XW, Duong MN, Wibley AL, Davis MA, Kelley K, Wilson MD, Parks JS, Rudel LL. Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 28(6):  E93 JUN  2008

Mulya A, Wilbley A, Chung SK, Gebre AK, Shelness GS, Parks JS. Impact of apolipoprotein M expression on pre-beta HDL formation by ATP binding cassette transporter A1 (ABCA1). Arteriosclerosis Thrombosis and Vascular Biology 27(6): E36 JUN 2007 

Polter A, Wibley A, Mullen JL, Wolverton C.  Gravitropism in akt1-1 roots lacks a significant DEZ contribution. American Society Plant Biologists P50: Abs# 415 JUL 2004 

 

 

 

Quick Reference

Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare

336-713-4259

kcollare@wakehealth.edu

Find A Doctor Ways to Give
Last Updated: 06-26-2014
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.