Christopher Stuart

Christopher Stuart

Fifth Year Student, 2015 – 2016

Year Matriculated: 2011

Email address:chstuart@wakehealth.edu

Education: Berry College; BS biochemistry/Biology Double Major

Advisor: William Gmeiner 

Research Interests:
My interests lie primarily in targeted delivery of synergistic drugs simultaneously. Of particular interest is synthesizing delivery vehicles that perform multiple roles, such as targeting the drug complex or changing the distribution of the drugs in the body.

Publications:

Gmeiner WH, Jennings-Gee J, Stuart CH, Pardee TS.
Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway. Leuk Res. 2015 Feb;39(2):229-35. doi: 10.1016/j.leukres.2014.11.006. Epub 2014 Nov 29.PMID:25510486

Gmeiner WH, Boyacioglu O, Stuart CH, Jennings-Gee J, Balaji KC. The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2. Prostate. 2015 Mar 1;75(4):360-9. doi: 10.1002/pros.22922. Epub 2014 Nov 18.PMID:25408502

Stuart CH, Horita DA, Thomas MJ, Salsbury FR Jr, Lively MO, Gmeiner WHSite-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells. Bioconjug Chem. 2014 Feb 19;25(2):406-13. doi: 10.1021/bc4005427. Epub 2014 Feb 6.PMID:24450459

Boyacioglu O, Stuart CH, Kulik G, Gmeiner WH  Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages. Mol Ther Nucleic Acids. 2013 Jul 16;2:e107. doi: 10.1038/mtna.2013.37.PMID:23860551

Extracurricular:

MMTS Executive Committee student representative, 2012-2014

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Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare

336-713-4259

kcollare@wakehealth.edu

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