Lan Gardner Coffman, MD, PhD
Residency, Internal Medicine
University of Michigan Hospitals
Ann Arbor, MI
MD, 2010, Wake Forest University
School of Medicine
Ph. D., Molecular Medicine 2008
Wake Forest University
School of Medicine
BS in Biology, minors in Chemistry and Statistics from Loyola College, Baltimore, MD 2003
I am working on a novel interaction between the iron storage protein, ferritin, and a blood coagulation/inflammation protein, high molecular weight kininogen. High molecular weight kininogen and its cleavage products, BK and HKa, modulate different aspects of inflammation and cancer. My project focuses on understanding ferritin’s role in altering these processes and the resultant effect in human physiology and pathophysiology.
Coffman LG, Parsonage D, D'Agostino R Jr, Torti FM, Torti SV. Regulatory effects of ferritin on angiogenesis. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):570-5. Epub 2009 Jan 6.
Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009 May;23(3):95-104. Epub 2008 Oct 2.
Coffman, LG, Brown, JC, Johnson, DA, Parthasarathy, N, D’Agostino, Jr RB, Lively, MO, Hua, X, Tilley, SL, Muller-Esterl, WP, Willingham, MC, Torti, FM, Torti, SV. 2008. Cleavage of high molecular weight kininogen by elastase and tryptase is inhibited by ferritin. Am J Physiol Lung Cell Mol Physiol, 2008 Mar;294(3):L505-15. Epub 2008 Jan 11
A. M. Collins , and L. M. Gardner. Partial Cytochrome b Sequences for Six Hymenoptera of the Eastern United States (2001) J Hered 92: 519-521.
Honors and Awards:
2006 American Heart Association pre-doctoral fellowship
2003 Carroll Medal in Biology, Loyola College
2002 Barry M. Goldwater Scholarship
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.