John Cravero, PhD
Office of Science Patent Attorney
U.S. Department of Energy
Ph.D., Molecular Medicine, 2008
Wake Forest University
School of Medicine
B.A., Augustana College, Rock Island, IL
Osteoarthritis, IGF-1 signaling pathways in the chondrocyte, the decrease in the chondrocyte’s response to IGF-1 that occurs with age and OA, and the role of age-related oxidative stress and how it contributes to the decreased IGF-1 response of the chondrocyte.
Postdoctoral Northwest University, August 2009
Cravero JD, Carlson CS, Im HJ, Yammani RR, Long D, Loeser RF. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum. 2009 Feb;60(2):492-500.
Starkman, B.G., Cravero, J.D., DelCarlo, M. Jr., Loeser, R.F. IGF-1 stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI3-kinase pathway but not ERK MAPK. Biochem. J. (2005) 389: 723-729.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.