Daniel Deegan, PhD

Deegan

2016 Molecular Medicine and Translational Science PhD Graduate

Year Matriculated: 
2009 

Education:

PhD, Molecular Medicine and Translational Science Graduate Program, December 2015
Wake Forest University School of Arts and Sciences

BS (Biology), 2009, Virginia Polytechnic Institute and State University (Virginia Tech)

Advisor: Thomas D. Shupe, PhD and Emmanuel C. Opara, PhD - WFIRM

Current Research: The National Kidney Foundation estimates that about 350,000 people in the United States have end-stage renal disease, and each year about 67,000 people die from kidney failure.  Transplant is the only way to restore continuous kidney function. Problems exist with finding a matching donor and transplant rejection within the patient.  Numbers show that only a small percentage of those people in need of transplants actually receive them. The data demonstrates a necessity to find a new supply of kidneys and increase histocompatibility for transplant. My research focuses on the production of a functional kidney for transplant through use of a decellularized porcine kidney scaffold and cells collected from a patient’s kidney biopsy. Characterization of the scaffold and understanding cell attachment is vital to the recellularization process and production of a histocompatible kidney.

Honors and Awards:

Phi Sigma Biology Honors Society
2013-2014 Graduate School Honor Council Student Representative

Publications:

Deegan D., Zimmerman C., Shupe T., Effects of Liver Specific Extracellular Matrix Hyaluronic Acid Gels of Varying Stiffnesses and Growth Factor Presence on Primary Hepatocyte Function.
Submitted to Biomaterials July 2015

 Ko IK, Peng L, Peloso A, Smith CJ, Dhal A, Deegan DB, Zimmerman C, Clouse C, Zhao W, Shupe TD, Soker S, Yoo JJ, Atala A., Bioengineered transplantable porcine livers with re-endothelialized vasculature.  Biomaterials. 2015 Feb; 40:72-9.

Sullivan D.C., Mirmalek-Sani S.H., Deegan D.B., Aboushwareb T., Baptista P.M., Atala A., Yoo J.J., Decellularization Methods of Porcine Kidneys for Whole Organ Engineering Using a High-Throughput System.  Biomaterials. 2012 Nov 28; 33(31):7756-64.

Antinozzi PA, Barnes BC, Deegan D, Ma L, Freedman BI, Murea M. Digital deconstruction of heterogeneous renal cell preparations with high-content imaging and cell specific biomarkers [abstract]. J Am Soc Nephrol. 2010; 21(Suppl):409A.

McDowell J.M., Hoff, T., Anderson, R., Deegan, D., 2011, Propogation, Storage, and Assays with Hyaloperonospora arabidopsidis, a model oomycete pathogen of Arabidopsis, Methods in Molecular Biology, 712:137-51.

Presentations:

Deegan D., “Effects of Liver Specific Extracellular Matrix Gels of Varying Stiffnesses and Growth Factor Presence on Primary Hepatocyte Function.” Molecular Medicine Seminar. Wake Forest University, Winston-Salem. 19 Sep. 2014.

Deegan D., “Effects of ECM Bound Growth Factors on Primary Hepatocyte Culture.” Molecular Medicine Seminar. Wake Forest University, Winston-Salem. 9 Sep. 2013.

Deegan D., "Effects of ECM Bound Growth Factors on Liver Cell Function." Molecular Medicine Seminar. Wake Forest University, Winston-Salem. 1 Mar. 2013.

Deegan D., "Growth Factor Retention on Decellularized Liver Scaffolds." Molecular Medicine Seminar. Wake Forest University, Winston-Salem. 11 May 2012.

Deegan D., "Characterization of a Decellularized Porcine Kidney Scaffold for Cellular Reattachment." Molecular Medicine Seminar. Wake Forest University, Winston-Salem. 25 Mar. 2011.

Deegan D., "Effects of SOD1 and MKK7 Expression on IGF Induced AKT and MAPK Signaling." Molecular Medicine Seminar. Wake Forest University, Winston-Salem. 7 May 2010.

Deegan D., "Development of a High Content Cell Based Assay for Renal Disease." Molecular Medicine Seminar. Wake Forest University, Winston-Salem. 13 Nov. 2009.

Poster:

Deegan D., Zimmerman C., Shupe T., Effects of Liver Specific Extracellular Matrix Hyaluronic Acid Gels of Varying Stiffnesses on Primary Hepatocyte Function. Wake Forest Institute for Regenerative Medicine, 2015

Deegan D., Zimmerman C., Shupe T., Effects of Increased Hydrogel Crosslinking and ECM Bound Growth Factors on Primary Hepatocyte Culture. Wake Forest Institute for Regenerative Medicine Retreat, 2013

Deegan D., Zimmerman C., Shupe T., Effects of Extracellular Matrix Bound Growth Factors on Primary Hepatocyte Culture. North Carolina Tissue Engineering and Regenerative Medicine Annual Conference and Innovation Summit, 2013

Deegan, Daniel. “Growth Factor Retention on Decellularized Liver Scaffolds” Wake Forest University. Molecular Medicine and Translational Sciences. May 11, 2012.

Deegan D.B., Sullivan D.C., Mirmalek-Sani S.H., Atala A., Yoo J.J., Aboushwareb T.,
Effects of Detergent Concentrations on Decellularized Porcine Kidney Scaffold
Wake Forest Institute for Regenerative Medicine Retreat, 2011

Conference Abstracts:

Deegan D.B., Sullivan D.C., Mirmalek-Sani S.H., Atala A., Yoo J.J., Aboushwareb T., Effects of Detergent Concentrations on Decellularized Porcine Kidney Scaffold Wake Forest Institute for Regenerative Medicine Retreat, 2011

 

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Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare

336-713-4259

kcollare@wakehealth.edu

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