Seventh Year PhD Student, 2015 - 2016
Year Matriculated: 2009
BS (Biology), 2009, Virginia Polytechnic Institute and State University (Virginia Tech)
Advisor: Thomas D. Shupe, PhD and Emmanuel C. Opara, PhD - WFIRM
Current Research: The National Kidney Foundation estimates that about 350,000 people in the United States have end-stage renal disease, and each year about 67,000 people die from kidney failure. Transplant is the only way to restore continuous kidney function. Problems exist with finding a matching donor and transplant rejection within the patient. Numbers show that only a small percentage of those people in need of transplants actually receive them. The data demonstrates a necessity to find a new supply of kidneys and increase histocompatibility for transplant. My research focuses on the production of a functional kidney for transplant through use of a decellularized porcine kidney scaffold and cells collected from a patient’s kidney biopsy. Characterization of the scaffold and understanding cell attachment is vital to the recellularization process and production of a histocompatible kidney.
Honors and Awards:
Phi Sigma Biology Honors Society
2013-2014 Graduate School Honor Council Student Representative
Sullivan D.C., Mirmalek-Sani S.H., Deegan D.B., Aboushwareb T., Atala A., Yoo J.J., "Evaluation of Decellularization Methods of Porcine Kidneys for Whole Organ Engineering Using a High-Throughput System." Biomaterials. 2012 (pending)
Antinozzi PA, Barnes BC, Deegan D, Ma L, Freedman BI, Murea M. Digital deconstruction of heterogeneous renal cell preparations with high-content imaging and cell specific biomarkers [abstract]. J Am Soc Nephrol. 2010; 21(Suppl):409A.
McDowell J.M., Hoff, T., Anderson, R., Deegan, D., 2011, Propogation, Storage, and Assays with Hyaloperonospora arabidopsidis, a model oomycete pathogen of Arabidopsis, Methods in Molecular Biology, 712:137-51.
Deegan, Daniel. “Growth Factor Retention on Decellularized Liver Scaffolds” Wake Forest University. Molecular Medicine and Translational Sciences. May 11, 2012.
Deegan D.B., Sullivan D.C., Mirmalek-Sani S.H., Atala A., Yoo J.J., Aboushwareb T.,
Effects of Detergent Concentrations on Decellularized Porcine Kidney Scaffold
Wake Forest Institute for Regenerative Medicine Retreat, 2011
Deegan D.B., Sullivan D.C., Mirmalek-Sani S.H., Atala A., Yoo J.J., Aboushwareb T., Effects of Detergent Concentrations on Decellularized Porcine Kidney Scaffold Wake Forest Institute for Regenerative Medicine Retreat, 2011