Daniel Deegan

Deegan

Fifth Year PhD Student, 2013 - 2014

Year Matriculated: 
2009 

E-mail:ddeegan@wakehealth.edu

Education:

BS (Biology), 2009, Virginia Polytechnic Institute and State University (Virginia Tech)

Advisor: James Yoo, Ph.D.; Tamer Aboushwareb, PhD:  Institute for Regenerative Medicine

Current Research: The National Kidney Foundation estimates that about 350,000 people in the United States have end-stage renal disease, and each year about 67,000 people die from kidney failure.  Transplant is the only way to restore continuous kidney function. Problems exist with finding a matching donor and transplant rejection within the patient.  Numbers show that only a small percentage of those people in need of transplants actually receive them. The data demonstrates a necessity to find a new supply of kidneys and increase histocompatibility for transplant. My research focuses on the production of a functional kidney for transplant through use of a decellularized porcine kidney scaffold and cells collected from a patient’s kidney biopsy. Characterization of the scaffold and understanding cell attachment is vital to the recellularization process and production of a histocompatible kidney.

Honors and Awards:

Phi Sigma Biology Honors Society
2013-2014 Graduate School Honor Council Student Representative

Publications:

Sullivan D.C., Mirmalek-Sani S.H., Deegan D.B., Aboushwareb T., Atala A., Yoo J.J., "Evaluation of Decellularization Methods of Porcine Kidneys for Whole Organ Engineering Using a High-Throughput System." Biomaterials. 2012 (pending)

Antinozzi PA, Barnes BC, Deegan D, Ma L, Freedman BI, Murea M. Digital deconstruction of heterogeneous renal cell preparations with high-content imaging and cell specific biomarkers [abstract]. J Am Soc Nephrol. 2010; 21(Suppl):409A.

McDowell J.M., Hoff, T., Anderson, R., Deegan, D., 2011, Propogation, Storage, and Assays with Hyaloperonospora arabidopsidis, a model oomycete pathogen of Arabidopsis, Methods in Molecular Biology, 712:137-51.

Poster:

Deegan, Daniel. “Growth Factor Retention on Decellularized Liver Scaffolds” Wake Forest University. Molecular Medicine and Translational Sciences. May 11, 2012.

Deegan D.B., Sullivan D.C., Mirmalek-Sani S.H., Atala A., Yoo J.J., Aboushwareb T.,
Effects of Detergent Concentrations on Decellularized Porcine Kidney Scaffold
Wake Forest Institute for Regenerative Medicine Retreat, 2011

Conference Abstracts:

Deegan D.B., Sullivan D.C., Mirmalek-Sani S.H., Atala A., Yoo J.J., Aboushwareb T., Effects of Detergent Concentrations on Decellularized Porcine Kidney Scaffold Wake Forest Institute for Regenerative Medicine Retreat, 2011

 

Quick Reference

Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare

336-713-4259

kcollare@wakehealth.edu

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