Daniel Eberli, M.D., PhD
Department of Urology
Ph.D., Molecular Medicine and Translational Science Graduate
Program, May 2007
Wake Forest University Graduate School of Arts and Sciences
1991 – 1997 Medical School of the University Zurich, Switzerland and Medical School of the University Vienna, Austria
1998 - 2003 Internship and Residency in Surgery and Urology
2002 Medical Research University Hospital Basel, Switzerland
2003 Laboratory for Tissue Engineering and Cellular Therapeutics: Harvard Medical School, Boston, MA
Over 13 million Americans experience urinary incontinence, the involuntary leakage of urine. Incontinence may be caused by the sphincter muscle and/or surrounding tissue damage due to the presence of various conditions, such as congenital anomaly, trauma, surgery and delivery. Multiple treatment modalities, including surgery and injection therapies into the urinary sphincter region have been tried to restore anatomical structure of the sphincter region with various results. However, none of these methods is able to restore normal sphincter muscle function. Cell based approaches to repair damaged tissue function have been proposed and applied experimentally and clinically in a variety of tissues and organs. Bladder neck structure restoration has been performed using injection, biological substitutes and bioengineered tissues with various outcomes. Functional restoration of sphincter muscle tissue using autologous cells would be an attractive option for patients with incontinence.
My research seeks to demonstrate that functional muscle tissue can be engineered using autologous myocytes, and that the restoration of sphincter function can be achieved in a sphincter insufficiency model as a pre-clinical translational study.
I have started a research laboratory and have currently 8 MDs and PhDs working with me on Tissue Engineering projects.
As a scientific physician I share my time between clinical and research duties (50 / 50). Together with Dr. Atlala and his group we have published 11 manuscripts over the last 2 years.