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Molecular Medicine and Translational Science Graduate Program Faculty Research Interests

Click here for Molecular Medicine and Translational Science Graduate Program Faculty List    

Adjunct faculty identified by * are available for committee service but not lab rotations.

Cancer Biology

Investigators in cancer biology use molecular approaches to study the underlying mechanisms of cancer and factors that contribute to tumor progression. Examples include identification of cancer susceptibility genes, genetic variation in tumor formation, DNA damage and repair pathways, cancer immunology and carcinogens.

Cui, Zheng, PhD, MD – Lipid signaling in apoptosis and carcinogenesis; cancer resistance in murine models

Debinski, Waldemar, MD, PhD - Identification of molecular markers/targets that are specific to brain tumors and are pharmaceutically tractable

Furdui, Cristina, PhD - Dynamic analysis of signaling events (protein phosphorylation and oxidation) at molecular and cellular level using quantitative, mass spectrometry based proteomics experiments; rapid enzyme kinetics.Lab page

Gmeiner, William H., PhD– Developing novel cytotoxic oligodeoxynucleotides for treatment of prostate cancer, DNA structure in carcinogenesis and chemotherapy

Levi, Nicole, PhD -  Cancer/oncogenesis, cross(mult/tnslat/inter)discip, drugs/therapeutic agents pharm, engineering/bioengineering, instrument development, model development 

Pasche, Boris C., PhD - Role of TGF-beta signaling pathway variants in tumor susceptibility and tumor progression.  Treatment of cancer with radiofrequency electromagnetic fields amplitude modulated at tumor-specific frequencies.

Poole, Leslie B., PhD - Biotechnology, cancer/oncogenesis, cell growth, differentiation,d, hormones/cytokines/signalling

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 


Cardiovascular Health and Disease

These investigators use molecular methods to investigate mechanisms related to diseases of the heart and circulatory system, including those that affect specific organs such as the brain, kidney, or placenta. Research areas include hypertension, circulation, cardiac function, coagulation, atherosclerosis, and aging.

Brosnihan, K. Bridget, PhD, MS– Role of Ang 1-7 in normal pregnancy and preeclampsia 

Chappell, Mark, PhD– Regulatory role of renin-angiotensin system in development of salt-dependent hypertension and tissue organ injury

Cheng, Che-ping, MD, PhD
– Cardiac dynamics, cellular signal transduction, and molecular alterations in CHF and alcoholic cardiomyopathy 

Ferrario, Carlos M, MD
- New endocrine mechanisms and the renin-angiotensin system in hypertension 

Furdui, Cristina, PhD- Dynamic analysis of signaling events (protein phosphorylation and oxidation) at molecular and cellular level using quantitative, mass spectrometry based proteomics experiments; rapid enzyme kinetics 

Geary, Randolph, MD
 - Artery wall remodeling in response to atherosclerosis and arterial injury; Restenosis following vascular reconstruction; Bioengineering of blood vessels; Functional genomics in artery wall biology

Herrington, David, MD, MHS * - The role of estrogen in the pathogenesis of coronary heart disease in postmenopausal women 

Hundley, Gregory, MD
 * - Magnetic resonance imaging assessment of cardiac function

Kim-Shapiro, Daniel, PhD
- The effects of Nitric Oxide and Aggregation in biological systems in relation to Sickle Cell Disease

King, Bruce, PhD- oxidative chemistry of N-hydroxyureas, formation of nitric oxide or nitroxyl (HNO)

Parks, John, PhD– The role of tissue-specific expression of ABCA1 in lipid metabolism, inflammation, and insulin resistance. The role of apoA-IV in hepatic lipid mobilization and hepatosteatosis. Atheroprotective mechanisms of botanical oils (borage and echium). The role of apoL1 risk variants in end-stage renal disease in African Americans. 

Smith, Thomas L., PhD
- Effects of exercise and PPAR? agonists on myocardial performance; Tissue engineered peripheral nerve conduits in mice; Regulation of neuromuscular function at the cellular level 

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Comparative Medicine

Comparative Medicine's research areas include: The effect of nutrition on disease risk; women’s health; cardiovascular disease; obesity/insulin resistance and diabetes; social stress and disease; behavioral medicine; and comparative oncology, with the majority of studies utilizing one of a range of available nonhuman primate models.

Appt, Susan E., DVM- Postmenopausal and perimenopausal women’s health, role of female reproductive hormones in disease risk, effect of obesity on reproductive function, atherosclerosis of females, nutrition, diabetes, preclinical surgical models.

Caudell, David L., DVM, PhD - Research Interests: Biotechnology, Cell Growth, Differentiation, Cross(mult/tnslat/inter)Discip, Drugs/Therapeutic Agents Pharm, Engineering/Bioengineering, Growth & Development, Health Services, Research/Outc, Hormones/Cytokines/Signalling, Immunology/Allergy/Inflammation, Instrument Development, Metabolism, Model Development, Vascular Diseases, Women's Health Issues.

Cline, J. Mark, DVM, PhD- Mitigation of Radiation Injury; Delayed Effects of Acute Radiation Exposure; Carcinogenesis; Comparative Cancer Biology; Spontaneous Cancer Models; Novel Cancer Therapies; Hormonal and Dietary Effects on Breast Cancer. 

Kavanagh, Kylie, DVM- Nutrition, obesity and insulin sensitivity; mechanisms of cardiovascular disease in diabetes and the role of heat shock proteins in diabetic complications; lipid metabolism.

Kock, Nancy D., DVM, PhD- Animal Models of Infectious Disease, Infectious Disease, Cancer, Effects of Irradiation.

Register, Thomas C., PhD- Aging; Endocrine and Nutritional Effects on Inflammation and Health; Cardiovascular Disease, Osteoporosis, Molecular Mechanisms of Regulation of Arterial and Bone Metabolism, Steroid Hormones and Hormone Receptors in Health and Disease, Molecular Genetics and Genomics.

Shively, Carol A., PhD-  Social Stress and Disease Susceptibility

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Diabetes and Metabolic Disorders (lipids, proteins, vitamins, renal function)

Research in these laboratories investigate molecular mechanisms of diabetes, diabetes related genes, hyperlipidemic diseases, coagulation, obesity, and renal function, often applying knockout models to investigate gene function.

Antinozzi, Peter A., PhD- Functional mapping of diabetes-susceptibility genes; functional mapping of complex diseases.

Bowden, Donald W., PhD- Identification of genes contributing to type 2 diabetes and the renal and cardiovascular complications of type 2 diabetes

Chilton, Ski, PhD- The role of fatty acid metabolism in human diseases; function of botanical lipids as dietary supplements

Poole, Leslie B., PhD-  Biotechnology, cancer/oncogenesis, cell growth, differentiation,d, hormones/cytokines/signalling

Weinberg, Richard B., MD- Structure and function of human apolipoprotein A-IV (apo A-IV); biophysical aspects of lipid-protein interactions, lipoprotein metabolism, dietary effects on human lipid metabolism, diet-gene interactions

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Genomics and Clinical Genetics

These scientists explore the contribution of specific genes to both physiologic and pathophysiologic processes. A major focus is on the experimental manipulation of genes and gene expression in human populations, animal models, and cell-based systems with analyses of phenotypic consequences. All studies are facilitated by advanced, high-throughput technologies in combination with functional computational analysis.

Antinozzi, Peter A., PhD- Functional mapping of diabetes-susceptibility genes; functional mapping of complex diseases  

Bowden, Donald, PhD
- Genetics of common diseases with emphasis identification of genes contributing to type 2 diabetes and the renal and cardiovascular complications of type 2 diabetes

Hawkins, Greg, PhD
* - Molecular genetics of complex diseases; severe asthma risk and pharmacogenomics

Howard, Timothy D., PhD
- Identification of genes for complex diseases, with a focus on cardiovascular and pulmonary diseases (asthma and allergy) 

Jewett, Tamison, MD
* - Genetic disorders of connective tissue, Fetal Alcohol Spectrum Disorders, Dysmorphology

Pettenati, Mark, PhD
* - Molecular cytogenetics

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Immunology and Inflammatory Diseases

These investigators utilize molecular, genetic, and biochemical approaches to identify the processes that mediate host defense against invasive microbial or viral pathogens and similar mechanisms involved in inflammatory tissue injury. This includes identifying mechanisms by which immune cells respond to infection, host cell-pathogen interaction, and regulation of inflammatory mediators.

Alexander-Miller, Martha, PhD- Regulation of CD8+ cytotoxic T lymphocytes; control of functional  avidity

Chilton, Ski, PhD- The role of fatty acid metabolism in human diseases; function of botanical lipids as dietary supplements

Daniel, Larry, PhD- Metabolic pathways responsible for forming lipid-derived second-messengers and the mechanism of action of these mediators in cancer and inflammation 

Feldman, Steve, MD, PhD- Patients' adherence to treatment, health care delivery research, psoriasis treatment

Ferguson, Cristin, MD
- Molecular Biology of Cartilage, Meniscus, Ligament Repair and Regeneration; Tissue Engineering; Growth Factors and Cell Signaling 

McCall, Charles E., MD
- The molecular events that control the inflammatory components of innate immunity

Poole, Leslie B., PhD
 -  Biotechnology, cancer/oncogenesis, cell growth, differentiation,d, hormones/cytokines/signalling

Seeds, Michael C., PhD
- Inflammation and host defense in the lung; regulation of secretory phospholipases A2; differential regulation of granulocyte apoptosis 

Taylor, Robert N., MD, PhD
- Inflammatory physiology and pathophysiology of embryonic implantation

Yammani, Ragunatha, PhD
- S100 proteins and cartilage physiology; role of S100A4 in the development of osteoarthritis

Yoza, Barbara, PhD* - Deciphering the molecular events associated with the onset and progression of septic shock, particularly as it relates to the synthesis inflammatory mediators from cells of the blood

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Neurological and Neuromuscular Function and Disorders

Faculty investigate molecular mechanism of stroke, neuromuscular disease, epilepsy, pediatric neurology and development, movement disorders, neuroplasticity, and neuro-rehabilitation. These laboratories employ a variety of genomic, physiologic, biochemical, pharmacological, dietary, and tissue engineering approaches to study disease treatment and prevention.

Delbono, Osvaldo, MD, PhD- Aging of the Neuromuscular System; reciprocal interaction between muscle cells and brain and spinal cord motor neurons

Eisenach, James, MD- Understanding neuroplasticity in the spinal cord as it relates to the pharmacology of analgesia

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Pulmonary Function and Disease 

Research in pulmonary medicine includes programs in airway smooth muscle and epithelial cell signal transduction, sequencing of genes associated with asthma and inflammation, disease-related phenotypes, and the response to medications used to treat these diseases. Other studies include phospholipase-mediated surfactant injury in asthma and ARDS and mechanisms regulating cell injury and death. Many of these studied involve human subjects.

Hawkins, Greg, PhD* - Molecular genetics of complex diseases; severe asthma risk and pharmacogenomics 

Howard, Timothy D., PhD
- Identification of disease genes for complex diseases, with a focus on cardiovascular and pulmonary diseases

Seeds, Michael C., PhD
- Inflammation and host defense in the lung; regulation of secretory phospholipases A2; differential regulation of granulocyte apoptosis

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Regenerative Medicine 

The mission of the Wake Forest Institute for Regenerative Medicine is to harness the body’s ability to heal itself. Using biomaterials, genetic engineering, stem and progenitor cells, and tissue engineering modalities, the Institute investigates translational approaches ranging from gene and cell therapy to the replacement of damaged organs with engineered tissues.

Atala, Anthony, MD - Tissue Engineering, Reconstructive Urology, Stem cells

Ferguson, Cristin, MD- Molecular Biology of Cartilage, Meniscus, Ligament Repair and Regeneration; Tissue Engineering; Growth Factors and Cell Signaling 

Geary, Randolph, MD
 - Artery wall remodeling in response to atherosclerosis and arterial injury; Restenosis following vascular reconstruction; Bioengineering of blood vessels; Functional genomics in artery wall biology

Lee, Sang Jin, PhD

Levi, Nichole, PhD- Cancer/oncogenesis, cross(mult/tnslat/inter)discip, drugs/therapeutic agents pharm, engineering/bioengineering, instrument development, model development

Smith, Thomas L, PhD- Effects of exercise and PPAR? agonists on myocardial performance; Tissue engineered peripheral nerve conduits in mice; Regulation of neuromuscular function at the cellular level

Soker, Shay, PhD
- Molecular and cellular biology of the vascular system; Stem and progenitor cell biology and genomics; angiogenesis 

Wagner, William D., PhD- Biotechnology, cross (mult/tnslat/inter)discip, surgery/trauma/burns/trauma

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

Surgery/Therapeutic Agents

Levi, Nicole, PhD - Cancer/oncogenesis, cross(mult/tnslat/inter)discip, drugs/therapeutic agents pharm, engineering/bioengineering, instrument development, model development

 Wagner, William D., PhD - Biotechnology, cross (mult/tnslat/inter)discip, surgery/trauma/burns/trauma  

Tsang, Allen W., PhD - My laboratory uses a combination of molecular assays, high-throughput omics and imaging technologies to understand chlamydial interaction with the infected host and to investigate the contribution of chlamydial co-infection with HPV to Cervical, Breast and Head and Neck cancer. Exploring novel bioactive plant-based compounds for new anti-chlamydial treatment strategies. 

 

Quick Reference

Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare

336-713-4259

kcollare@wakehealth.edu

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