Amy Hicks

Amy Hicks

Post Doc, Jackson Labs
Bar Harbor, ME

Email:   amy.hicks@jax.org

Education:

PhD, Molecular Medicine and Translational Science, 2012, Wake Forest School of Medicine
BS (Biochemistry), 2005, University of Maine
BS (Molecular and Cellular Biology), 2005, University of Maine

Advisor: Colin Bishop, Ph.D.: Institute of Regenerative Medicine 

Current Research:

Using transposon-mediated, gene-trap mutagenesis, we have recently generated a novel, recessive mouse mutant affecting the urinary bladder, termed Bloated Bladder (Blad). Homozygous mutants die soon after birth with a grossly distended bladder which we hypothesize impairs their ability to breath. Preliminary molecular genetic analysis indicates that the Blad phenotype is caused by a loss-of-function mutation in nicotinamide 5’-mononucleotide adenyltransferase 2 (Nmnat2) on chromosome 1.  This gene has been shown to localize to the Golgi complex and is predominantly expressed in the brain. The loss of Nmnat2 expression in Blad mutants suggests its activity is important in bladder functionality during development.  Our hypotheses are (1) that the enlarged bladder observed in Blad mutant mice is due to a voiding failure, secondary to an innervation defect (2) the perinatal lethality is caused by the enlarged bladder physically making breathing impossible or again innervation of the diaphragm/lungs is at fault.  Further characterization of the local and systemic effects of this gene deletion in this mouse model need to be determined, but experiments are underway to identify the mechanism causing the observed bladder distention. 

Honors/Awards: 

July 2012          Society for Neuroscience Travel Award  (FENS 2012)
July 2012          Wake Forest University Alumni Student Travel Award (FENS 2012)
Nov 2011          Molecular Medicine & Translational Sciences Program Travel Award (Neuroscience)
Dec 2010         American Society for Cell Biology Education Committee Travel Award
Dec 2010         Wake Forest University Alumni Student Travel Award     
Dec 2010         Molecular Medicine & Translational Sciences Program Travel Award
March 2010      1st Place Oral Presentation at Annual Wake Forest Institute for Regen. Med. Retreat
2008-2009       Molecular Medicine and Translational Sciences Program Training Grant Award

Publications: 

Augusto Zani*, Mara Cananzi*, Francesco Fascetti-Leon, Giuseppe Lauriti, Virpi V Smith, Neil J Sebire, Sveva Bollini, Michela Pozzobon, Martina Piccoli, Jack and Bernard, Amy N. Hicks, Colin Bishop, Anthony Atala, Antonello D'Arrigo, Alberta Leon, Mark Lythgoe, Agostino Pierro, Simon Eaton, Paolo De Coppi.  Amniotic Fluid Stem Cells Improve Survival And Enhance Repair Of Damaged Intestine In Experimental Necrotizing Enterocolitis Via A Cox-2 Dependent Mechanism. (Submitted to the Journal of Clinical Investigation)

Hicks AN, Lorenzetti D, Lu B, Andersson KE, Overbeek PA, Oppenheim R, Bishop CE. Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) plays a key role in the survival of peripheral nerves in the mouse embryo. (Submitted to PLoS ONE)

Gallagher CJ, Muscat JE, Hicks AN, Zheng Y, Dyer A, Chase GA, Richie JP Jr., Lazarus P.  Sex-specific association of the UDP-glucuronosyltransferase 2B17 gene deletion with decreased glucuronidation of NNAL and increased risk for lung cancer. Cancer Epidemiol Biomarkers Prev. 2007 April;16(4):823-8.

Pan C, Hicks A, Guan X, Chen H, Bishop CE.SNL fibroblast feeder layers support derivation and maintenance of human induced pluripotent stem cells. J Genet Genomics. 2010 Apr;37(4):241-8.

  

Oral Presentations: 

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Paul Overbeek, Colin Bishop. Nervous System Defects in the Novel Bloated Bladder Mouse Mutant (Blad).  The Molecular Medicine and Translational Science Seminar Series, Winston Salem, NC, Sept 2011.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Paul Overbeek, Colin Bishop. Genetic Analysis of the Novel Mouse Bloated Bladder Mutant (Blad).  The Wake Forest Institute for Regenerative Medicine Annual Retreat, Winston Salem, NC, March 2010.
Award: 1st Place Oral Presentation   

Conference Abstracts:

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Karl-Erik Andersson, Paul Overbeek, Ronald Oppenheim, Colin Bishop. Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) plays a key role in the in vivo survival of peripheral nerves in developing mouse embryos. Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, Barcelona, Spain, July 2012.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Karl-Erik Andersson, Paul Overbeek, Ronald Oppenheim, Colin Bishop. Nervous System Defects in the Novel Bloated Bladder Mouse Mutant (Blad).  Society for Neuroscience Annual Meeting, Washington, DC, November 2011.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Karl-Erik Andersson, Paul Overbeek, Ronald Oppenheim, Colin Bishop. Nervous System Defects in the Novel Bloated Bladder Mouse Mutant (Blad). Society for Neuroscience Annual Meeting, Washington, DC, November 2011.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Karl-Erik Andersson, Paul Overbeek, Colin Bishop. Characterization of the Novel Bloated Bladder Mouse Mutant (Blad).  WFU Graduate & Post Doctoral Research Day, Winston Salem, NC, March 2011.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Karl-Erik Andersson, Paul Overbeek, Colin Bishop. Characterization of theBladder Disfunction in the  Novel Bloated Bladder (Blad) Mouse Mutant. The Wake Forest Institute for Regenerative Medicine Annual Retreat, Pinehurst, NC, March 2011. 

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Paul Overbeek, Colin Bishop. Characterization of the Novel Bloated Bladder Mouse Mutant (Blad).  The American Society for Cell Biology Annual Conference, Philadelphia, PA, December 2010.  Travel Awards: ASCB Education Committee Travel Award, WFU Alumni Student Travel Award, and Molecular Medicine & Translational Sciences Program Travel Award

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Paul Overbeek, Colin Bishop. Characterization of the Novel Bloated Bladder Mouse Mutant (Blad).  The North Carolina Tissue North Carolina Tissue Engineering and Regenerative Medicine Conference, Durham, NC, November 2010.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Paul Overbeek, Colin Bishop. Genetic Analysis of the Novel Mouse Bloated Bladder Mutant (Blad).  WFU Graduate & Post Doctoral Research Day, Winston Salem, NC, March 2010.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Paul Overbeek, Colin Bishop. Genetic Analysis of the Novel Mouse Bloated Bladder Mutant (Blad).  The Wake Forest Institute for Regenerative Medicine Annual Retreat, Pinehurst, NC, March 2010.

Amy N. Hicks, Diego Lorenzetti, Baisong Lu, Paul Overbeek, Colin Bishop. Genetic Analysis of the Novel Mouse Bloated Bladder Mutant (Blad).  The North Carolina Tissue North Carolina Tissue Engineering and Regenerative Medicine Conference, Winston Salem, NC, November 2009. 

Diego Lorenzetti, Amy N. Hicks, Baisong Lu, Paul Overbeek, Colin Bishop. Genetic Analysis of the Novel Mouse Bloated Bladder Mutant (Blad).  The Wake Forest Institute for Regenerative Medicine Annual Retreat, Asheville, NC, April 2009. 

Gang Chen, Ryan Dellinger, Carla Gallagher, Dongxiao Sun, Gary Chase, Thomas Spratt, Joshua Muscat, John Richie, Amy Hicks, Philip Lazarus.  UGT2B10 is a major glucuronidator of tobacco-specific nitrosamines; association of UGT2B10 haplotypes with glucuronidation phenotypes in humans. The American Association for Cancer Research Annual Meeting, Los Angeles, CA, April 2007.

Gallagher CJ, Muscat JE, Hicks AN, Dyer A, Chase GA, Richie JP Jr., Lazarus P.  Gender-specific association of the UGT2B17 gene deletion with decreased glucuronidation of NNAL and increased risk for lung cancer.  American Association for Cancer Research: Frontiers in Cancer Prevention Meeting, Boston, MA, November 2006. 

Amy N. Hicks, Carla J Gallagher, Joshua E. Muscat, Jong-in Hahm, Philip Lazarus. Haplotyping the UGT 1A Locus using Single-walled Carbon Nanotube Scanning Probes. The Penn State University Genetics Symposium, State College, PA, April 2006.

Gallagher CJ, Hicks AN, Zheng Y, Dyer A, Chase GA, Muscat JE, Lazarus P.  UGT2B17 gene deletion and lung cancer risk.  The American Association for Cancer Research Annual Meeting, Washington, DC, April 2006.

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Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare

336-713-4259

kcollare@wakehealth.edu

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