Caitrin McDonough, PhD

mcdonough

Research Assistant Professor
University of Florida
Gainesville, FL

Email:caitrinmcdonough@ufl.edu

Education:

PhD, Molecular Medicine and Translational Science, 2005-2010
Wake Forest University
School of Medicine
Winston-Salem, NC
Advisor: Donald W. Bowden

BS in Biochemistry, 2005 
University of Iowa 

Current Research:

My postdoctoral research is focused on cardiovascular drug pharmacogenomics.  Hypertension (HTN) is estimated to affect nearly 1 billion individuals worldwide, making it the most common chronic disease in the world.  However, there is great patient variability in antihypertensive drug response.  The goal of my research is to identify novel genetic markers that associate with improved outcomes in patients with hypertension, and can help identify what drugs a patient may or may not respond to.  My work will include the analysis of genome-wide data from a hypertensive population were patients were randomized to a beta-blocker strategy or a calcium-channel blocker strategy; coupled with identifying the functional variant(s) and determining the mechanisms behind the strongest genetic signals.

My graduate research was focused on type 2 diabetes and diabetic complications: specifically, diabetic nephropathy.  Over the past 25 years the number of Americans with type 2 diabetes mellitus (T2DM) has more than doubled.  This has also correlated with increases in diabetic complications.  In the United States, diabetes is the leading cause of end-stage renal disease (ESRD), accounting for 45% of new cases.  Epidemiologic evidence has shown familial clustering of diabetic nephropathy (DN), suggesting the contribution of genetic factors.  My work included the use of a genome wide association study, a genome wide linkage scan, fine-mapping, dense SNP mapping, sequencing, and candidate gene analysis to identify genes associated with T2DM-ESRD susceptibility in African Americans and Caucasian Americans.

Honors and Awards:

3rd Place, University of Iowa Biosciences Undergraduate Poster Competition, September 2004.

Post Doc Appointment on the University of Florida Nephrology T32 Training Grant.  July 2010 – present.

Publications:

Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Yard BA, van der Woude FJ, Bowden DW.  A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans.  NDT.  2007 Apr;22(4):1131-5. Epub 2007 Jan 5.

McDonough CW, Hicks PJ, Lu L, Langefeld CD, Freedman BI, Bowden DW.  The Influence of Carnosinase Gene Polymorphisms on Diabetic Nephropathy Risk in African-Americans.  Hum Genet. 2009 Aug; 126(2):265-75.

McDonough CW, Bostrom MA, Lu L, Hicks PJ, Langefeld CD, Divers J, Mychaleckyj JC, Freedman BI, Bowden DW.  Genetic Analysis of Diabetic Nephropathy on Chromosome 18 in African Americans: Linkage Analysis and Dense SNP Mapping. Hum Genet. 2009 Dec; 126(6):805-817.

Schulze SR, Curio-Penny B, Speese S, Dialynas G, Cryderman DE, McDonough CW, Nalbant D, Petersen M, Budnick V, Geyer PK, Wallrath LL.  A comparative study of Drosophila and human A-type lamins.  PLoS One. 2009 Oct; 4(10):e7564.

Abstracts:

McDonough CW, Hicks PJ, Freedman BI, Bowden DW.  Genetic evaluation of CNDP1 and CNDP2 polymorphisms in Diabetic Nephropathy.  Am J Hum Genet  81(4) suppl: 2007, 481.

McDonough CW, Hicks PJ, Freedman BI, Bowden DW.  Genetic evaluation of CNDP1 and CNDP2 polymorphisms in Diabetic Nephropathy.  J Am Soc Nephrol 18: 2007, 607A. 

McDonough CW, Hicks PJ, Freedman BI, Bowden DW.  Association of the Carnosinase Genes (CNDP1 and CNDP2) with Diabetic Nephropathy (DN) in African Americans (AA).  J. Am. Soc. Nephrol. 19: 2008, 132A. 

McDonough CW, Bostrom M, Lu L, Hicks PJ, Langefeld CD, Divers J, Freedman BI, Bowden DW.  Identifying Diabetic Nephropathy Genes on Chromosome 18 in African Americans: A Dense SNP Map.  Am. J. Hum. Genet.  83(5) suppl: 2008, 416.

Palmer ND, McDonough CW, Smith S, Langefeld CD, Divers J, Lu L, Freedman BI, Bowden DW.  A Genome-wide Association Study in 1997 African Americans reveals candidate susceptibility loci for Type 2 Diabetes.  Am. J. Hum. Genet. 85(5) suppl. 2009.

McDonough CW, Palmer ND, Bostrom MA, Hicks PJ, Lu L, Divers J, Langefeld CD, Freedman BI, Bowden DW.  A Genome-Wide Association Study of Diabetic Nephropathy in African Americans.  Am. J. Hum. Genet. 85(5) suppl. 2009.

McDonough CW, Palmer ND, Bostrom MA, Hicks PJ, Lu L, Divers J, Langefeld CD, Freedman BI, Bowden DW.  A Genome-Wide Association Study (GWAS) of Diabetic Nephropathy (DN) in African Americans (AA).  J. Am. Soc. Nephrol. 20: 2009, 433A.

McDonough CW, Palmer ND, Bostrom MA, Hicks PJ, Roh BH, Wing MR, Cooke JN, Hester JM, An SS, Talbert ME, Lu L, Ng MCY, Divers J, Langefeld CD, Freedman BI, Bowden DW.  A Genome Wide Association Study for Diabetic Nephropathy Genes in African Americans.  Diabetes.  59 suppl 1:  2010, A56.

Palmer ND, McDonough CW, Langefeld CD, Divers J, Lu L, Freedman BI, Bowden DW.  A Genome-wide Association Study in African Americans Reveals Novel Susceptibility Loci for Type 2 Diabetes.  Diabetes. 59 suppl 1: 2010, A115.

McDonough CW, Palmer ND, Hicks PJ, Bostrom MA, Lu L, Ng MCY, Langefeld CD, Freedman BI, Bowden DW.  A Genome-Wide Association Study (GWAS) for Diabetic Nephropathy (DN) genes in African Americans (AA).  Accepted to the 2010 Annual meeting of the American Society of Nephrology.

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Kopp JB, Winkler CA, Nelson GC, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW.  Accounting for risk variants in MYH9 reveals FRMD3 association with diabetic ESRD in African Americans. Accepted to the 2010 Annual meeting of the American Society of Nephrology.

 

 

 

 

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