Sally Mokhtari, PhD
Project Development Scientist
City of Hope
Los Angeles, CA
Year Matriculated: 2010
Transfer from University of Nevada-Reno
BS in Cell and Molecular Biology, Genetics, University of Isfahan, Iran
PhD, Molecular Medicine and Translational Science Graduate Program, August 2015
Wake Forest Graduate School of Arts and Sciences
Advisor: Graca Almeida-Porada MD,PhD; Institute of Regenerative Medicine
Studies suggest that within the marrow there are at least two anatomically and physiologically distinct hematopoeitic niches: the osteoblastic and the vascular niche. Whitin these niches numerous molecules and secreted factors have been implicated in the strictly regulated process of hematopoiesis. Nevertheless, a through understanding of subpopulation of hematopoietic stem cell (HSC) that interact with each niche and physiological role of each niche type in the regulation of stem cell hierarchy and function is still missing. We hypothesis that the developmental process whereby the fetal marrow acquires the ability to support hematopoiesis can be used as a model for understanding both the interactions that occur between HSC and the cells comprising the marrow niches, and the role of these niche elements in the initiation/maintenance of hematopoiesis. Therefore, our goal is to identify the cellular interactions that occur within each of the niches at the phenotypical, functional, and transcriptional levels. We further hypothesis that this knowledge will provide the necessary tools for manipulating these niches to facilitate the engraftment and accelerate hematopoietic recover of donor HSC after HSC transplantation.
American Society of Hematology Achievement Award, 2015.
MMTS Travel Award to attend In-Utero Transplantation meeting in San Francisco, CA, April 18-19, 2014. Poster presentation: "Optimization of Vascular Niches to Increase Hematopoietic Engraftment".
Grant award to cover registration at the International Symposium in Applied Bioimaging 2013 meeting, held in Porto, Portugal, October 2013.
3rd place poster presentation award for 2013 WFIRM retreat.
Fall 2012 MMTS Travel Award to attend American Society of Hematology meeting in Atlanta, GA, December 2012.
Outstanding Podium Talk in the 13th annual conference of the North Carolina Tissue Engineering and Regenerative Medicine Society. November 4, 2011.