Thorsten M. Seyler, MD, PhD
Duke University Health System, Orthopaedic Surgery
Duke University Medical Center
Ph.D., Molecular Medicine and Translational Science Graduate Program, 2014
Wake Forest University Graduate School of Arts and Sciences
Semmelweis University for MedicalScience- Budapest, Hungary 1998-2000
Ruprecht-Karls-University -Heidelberg, Germany 2000-2005
Mayo Medical and Graduate School, Rochester, Minnesota 2004
Emory University, Atlanta, Georgia 2002-2003
Wake Forest University, Graduate School of Arts & Sciences, Winston-Salem, North Carolina 2007-present
Tissue engineering is an emerging field that will significantly contribute to the development of novel therapeutic strategies in ACL reconstruction in the coming years. Over the last decade, various synthetic and naturally-derived tissue engineered scaffolds for ACL repair have been developed. The use of synthetic ligament grafts gained popularity in the late 1980s, and current tissue-engineering strategies have relied predominantly upon these scaffolds. Advantages of using synthetic grafts include the elimination of autogenous tissue harvest, donor site morbidity, and risk of disease transmission. However, synthetic grafts have been associated with a high incidence of chronic foreign body inflammation, debris-induced synovitis, mechanical limitations, and complete graft rupture.
In recent years, the focus shifted to the use of naturally derived scaffolds and materials. Naturally-derived scaffolds combine several important advantages including:
- Elimination of additional surgical procedures to harvest tissue (decreased operative time)
- Minimal patient morbidity (no requirement for tendon graft harvest)
- Simple surgical technique for implantation with established fixation methods
- Mechanical integrity for a duration sufficient to allow host tissue ingrowth and allow for immediate stabilization of the knee
- Biocompatibility of the graft material and enhanced host remodeling
- Preservation of the extracellular protein matrix (cell attachment and proliferation)
- Biodegradation at a rate sufficient to allow for complete integration of the bioengineered tissue into the host tissue following implantation and until complete remodeling has occurred in vivo
- Minimal risk for infection or disease transmission
To date, decellularized tissues have been successfully used in a variety of tissue engineering/regenerative medicine applications. My research work is based on the hypothesis that a novel, decellularized, biocompatible, human, allograft tissue-derived scaffold (HAS) demonstrates equivalent biomechanical properties, and an improved rate of osteointegration and graft remodeling when compared to current existing graft choices including: (1) freeze-dried human Achilles tendon allograft, and (2) fresh frozen human Achilles tendon allograft. This would eliminate the limitations associated with present day graft choices and has the potential to significantly improve the treatment of ACL injuries.
Selected Peer-Reviewed Publications
Seyler TM, Park YW, Takemura S, Bram RJ, Kurtin PJ, Goronzy JJ, Weyand CM. BLyS and APRIL in rheumatoid arthritis. J Clin Invest. 2005;115(11):3083-92.
Weyand CM, Seyler TM, Goronzy JJ. B cells in rheumatoid synovitis. Arthritis Res Ther. 2005;7 Suppl 3:S9-12.
Park YW, Pryshchep S, Seyler TM, Goronzy JJ, Weyand CM. B cells as a therapeutic target in autoimmune diseases. Expert Opin Ther Targets. 2005;9(3):431-45.
Diaz-Borjon A, Seyler TM, Chen NL, Lim SS. Bisphosphonate associated arthritis. J Clin Rheumatol, 2006 Jun;12(3):131-3.
Mont MA, Seyler TM, Ragland PS, Starr R, Erhart J, Bhave A. Gait analysis of patients with resurfacing hip arthroplasty compared to hip osteoarthritis and standard total hip arthroplasty. J Arthroplasty, 2007 Jan;22(1):100-8.
Mont MA, Seyler TM, Kester M, McMahon M, Bonutti PM. Minimally invasive revision total knee arthroplasty. Clin Orthop Relat Res. 2006 May;446:69-75.
Mont MA, Seyler TM, Marulanda GA, Delanois RE, Bhave A. Surgical treatment and customized rehabilitation for stiff knee arthroplasties. Clin Orthop Relat Res. 2006 May;446:193-200.
Mont MA, Ragland PS, Etienne G, Seyler TM, Schmalzried TP. Hip resurfacing arthroplasty. J Am Acad Orthop Surg, 2006;14(8):454-63.
Mont MA, Jones LC, Seyler TM, Marulanda GA, Saleh KJ, Delanois RE. New treatment approaches for osteonecrosis of the femoral head: An overview. Instr Course Lect. 2007;56:197-212.
Marulanda GA, Seyler TM, Sheikh N, Mont MA. Percutaneous drilling for the treatment of secondary osteonecrosis of the knee. J Bone Joint Surg Br, 2006 Jun;88(6):740-6.
Seyler TM, Cui Q, Mihalko WM, Mont MA, Saleh KJ. Advances in hip arthroplasty in the treatment of osteonecrosis. Instr Course Lect. 2007;56:221-33.
Delanois RE, Seyler TM, Essner A, Schmidig G, Mont MA. Cementation of a polyethylene liner into a metal shell: Wear characteristics. J Arthroplasty, 2007 Aug;22(5):732-7. Epub 2007 Apr 20.
Mont MA, Marulanda GA, Seyler TM, Plate JF, Delanois RE. Core decompression and non-vascularized bone grafting for the treatment of early-stage osteonecrosis of the femoral head. Instr Course Lect, 2007;56:213-20.
Seyler TM, Bonutti PM, Shen J, Naughton M, Kester M. The use of an alumina-on-alumina bearing system in total hip arthroplasty for osteonecrosis of the hip. J Bone Joint Surg Am, 2006 Nov;88 Suppl 3:116-25.
Bonutti PM, Seyler TM, Delanois RE, McMahon M, McCarthy JC, Mont MA. Osteonecrosis of the knee after laser and radiofrequency-assisted arthroscopy: Treatment with minimally invasive knee arthroplasty. J Bone Joint Surg Am, 2006 Nov;88 Suppl 3:69-75.
Mont MA, Seyler TM, Plate JF, Delanois RE, Parvizi J. Uncemented total hip arthroplasty in young patients with osteonecrosis of the femoral head: A comparative study. J Bone Joint Surg Am, 2006 Nov;88 Suppl 3:104-9.
Mont MA, Seyler TM, Marker DR, Marulanda GA, Delanois RE. Use of metal-on-metal total hip resurfacing for osteonecrosis of the femoral head: An analysis of 42 hips compared to osteoarthritis. J Bone Joint Surg Am, 2006 Nov;88 Suppl 3:90-7.
Seyler TM, Mont MA, Ragland PS, Kachwala MM, Delanois RE. Sports activity after hip and knee arthroplasty: Specific recommendations concerning tennis. Sports Med, 2006;36(7):571-83.
Mont MA, Marker DR, Seyler TM, Gordon N, Hungerford DS, Jones LC. Knee Arthroplasties Have Similar Results in High- and Low-activity Patients. Clin Orthop Relat Res. 2007 Feb 15; [Epub ahead of print]
Leadbetter WB, Seyler TM, Ragland PS, Mont MA. Indications, Contraindications, and Pitfalls of Patellofemoral Arthroplasty. J Bone Joint Surg Am, 2006 Dec;88 Suppl 4:122-37.
Ulrich SD, Seyler TM, Bennett D, Delanois RE, Saleh KJ, Thongtrangan I, Kuskowski M, Cheng EY, Sharkey PF, Parvizi J, Stiehl JB, Mont MA. Total hip arthroplasties: What are the reasons for revision? Int Orthop, 2007 Apr 19; [Epub ahead of print]
Mont MA, Ulrich SD, Seyler TM. Role of thrombotic and fibrinolytic alterations in the pathogenesis and treatment of osteonecrosis. J Rheumatol, 2007 Mar;34(3):466-8.
Boyd HS, Ulrich SD, Seyler TM, Marulanda GA, Marker DR, Mont MA. Resurfacing for Perthes Disease: An Alternative to Standard Hip Arthroplasty. Accepted for publication, Clin Orthop Relat Res. 2007 Aug 9; [Epub ahead of print]
Ulrich SD, Bhave A, Marker DR, Seyler TM, Mont MA. Focused Rehabilitation Treatment of Poorly Functioning Total Knee Arthroplasties. Clin Orthop Relat Res. 2007 Aug 9; [Epub ahead of print]
Ulrich SD, Mont MA, Bonutti PM, Seyler TM, Marker DR, Jones LC. Scientific evidence supporting computer-assisted surgery and minimally invasive surgery for total knee arthroplasty. Expert Rev Med Devices. 2007 Jul;4(4):497-505.
Mont MA, Bonutti PM, Seyler TM, Plate JF, Delanois RE, Kester M. The future of high performance total knee arthroplasty. Semin Arthroplasty. 2006;17(2): 80-87.
Mont MA, Bonutti PM, Seyler TM, Plate JF, Delanois RE, Kester M. The future of high performance total hip arthroplasty. Semin Arthroplasty. 2006;17(2): 88-92.
Seyler TM, Bonutti PM, Ragland PS, Marulanda GA, Mont MA. Minimally invasive lateral approach to total knee arthroplasty. Semin Arthroplasty. 2005;16(3): 223-226, 2005
Seyler TM, Marulanda GA, Delanois RE, Mont MA. Limited approach surface replacement total hip arthroplasty. Oper Tech Ortho, 2006 April;16(2):120-125.
Akbar M, Abel R, Seyler TM, Gerner HJ, Mohring K. Repeated botulinum-A toxin injections in the treatment of myelodysplastic children and patients with spinal cord injuries with neurogenic bladder dysfunction. BJU Int. 2007 Sep;100(3):639-45. Epub 2007 May 26.
Ulrich SD, Bonutti PM, Seyler TM, Marker DR, Jones LC, Mont MA.Outcomes-based evaluations supporting computer-assisted surgery and minimally invasive surgery for total hip arthroplasty. Expert Rev Med Devices. 2007 Nov;4(6):873-883.
Marker DR, Seyler TM, Jinnah RH, Delanois RE, Ulrich SD,Mont MA. Femoral neck fractures after metal-on-metal total hip resurfacing: a prospective cohort study. J Arthroplasty. 2007 Oct;22(7 Suppl 3):66-71.
Seyler TM, Bonutti PM, Ulrich SD, Fatscher T, Marker DR, Mont MA. Minimally invasive lateral approach to total knee arthroplasty. J Arthroplasty. 2007 Oct;22(7 Suppl 3):21-6.
Seyler TM, Marker DR, Bhave A, Plate JF, Marulanda GA, Bonutti PM, Delanois RE, Mont MA. Functional problems and arthrofibrosis following total knee arthroplasty. J Bone Joint Surg Am. 2007 Oct;89 Suppl 3:59-69.
Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of Musculoskeletal Bacterial Infections by [I]FIAU-PET/CT. PLoS ONE. 2007 Oct 10;2(10):e1007.
Seyler TM, Etienne G, Plate JF, Fisher P, Mont MA. Use of modular large femoral heads without liners in hip arthroplasty. Surg Technol Int. 2006;15:217-20.
Marulanda GA, Ragland PS, Seyler TM, Mont MA. Reductions in blood loss with use of a bipolar sealer for hemostasis in primary total knee arthroplasty. Surg Technol Int. 2005;14:281-6.
Behave A, Marker DR, Seyler TM, Ulrich SD, Plate JF, Mont MA. Functional problems and treatment solutions after total hip arthroplasty. J Arthroplasty. 2007 Sep;22(6 Suppl 2):116-24.
Mont MA, Seyler TM, Ulrich SD, Beaule PE, Boyd HS, Grecula MJ, Goldberg VM, Kennedy WR, Marker DR, Schmalzried TP, Sparling EA, Vail TP, Amstutz HC. Effect of Changing Indications and Techniques on Total Hip Resurfacing. Clin Orthop Relat Res. 2007 Sep 20; [Epub ahead of print]
Childress L, III, Ulrich SD, Seyler TM, Delanois RE, Marker DR, Mont MA. Role of Metal-on-Metal Resurfacing in the Treatment of Late Stage Osteonecrosis. Semin Arthroplasty. 2007;18(3): 216-219