Sinan Zhu, PhD
Memorial Sloan Kettering Cancer Center
New York, NY
Year Matriculated: 2009
PhD, Molecular Medicine and Translational Science, December 2013, Wake Forest University Graduate School of Arts and Sciences, Winston Salem, NC
BEng (Bioengineering), 2007, Chongqing University, China
MSc (Molecular Biology), 2009, Jacobs University Bremen, Germany
Advisor: Guangchao Sui, PhD; Cancer Biology
Study the transcriptional function of Cyclin D1 on p19ARF and p16INK4a promoters, and biological significance of Dmp1 - Cyclin D1 interaction in breast and lung cancer. By using real-time PCR to analyze the gene amplification / deletion of Dmp1, p53, and Ink4a/arf in 23 pairs of human breast carcinomas, it is found that in some patients, Dmp1, p53 or Ink4a/arf loci have various degree of deletion. The tissue microarray staining of human Dmp1 demonstrates that Breast cancer samples with hDMP1 LOH (-) show more intense nuclear staining for hDMP1.
Honors and Awards:
WFU Cancer Biology Retreat Poster Award, Second Prize (2011).
Pankaj Taneja, Dejan Maglic, Fumitake Kai, Sinan Zhu, Robert D. Kendig, Elizabeth A. Fry and Kazushi Inoue. Classical and Novel Prognostic Markers for Breast Cancer and their Clinical Significance. Clinical Medicine Insights: Oncology 2010:4 15-34
Taneja P, Zhu S, Maglic D, Fry EA, Kendig RD, and Inoue K. Transgenic and knockout mice models to reveal the functions of tumor suppressor genes. Clinical Medicine Insights: Oncology. 2011; In Press
Posters and Presentations:
Zhu S, Taneja P, Kendig R, Kai F, Maglic D, and Inoue K. Cyclin D1 regulates the ARF and INK4a promoters. Poster session presented at: 102th AACR annual meeting; April 2-6, 2011; Orland, Florida.