Matthew Talbert, PhD
Department of Biology
University of Louisiana at Monroe
Ph.D., Molecular Medicine and Translational Science Graduate
Program, Dec. 2009
Wake Forest University Graduate School of Arts and Sciences
BS in Biology and a concentration in Medical Humanities, 2005
Davidson College, Davidson, NC
The current focus of my research is identifying the genetic components that contribute to the development and molecular pathology of obesity. I assist in the ongoing effort to complete the positional cloning of novel obesity genes in the Insulin Resistance and Atherosclerosis Family Study (IRASFS). As part of this effort, I am performing SNP association analysis of positional functional candidates as a result of genome-wide association studies in the IRASFS Hispanic and African American cohorts. I determine whether inheritable variations in various genomic regions (usually genes) have an effect on quantitative adiposity phenotypes (such as body-mass index or visceral adipose tissue) in our population set. As one of the most poorly understood, yet prevalent, complex disorders facing the western world, the research of the IRASFS and others may prove critical in advancing the understanding and clinical treatments of obesity.
Honors and Awards:
- T32 Institutional Training Grant, National Institute of Health, WFBMC Fall 2007-March 2009
- Research Fellowship, WFBMC 2005-Present
- Who’s Who Among American College Students 2004-2005
Talbert ME, Langefeld CD, Ziegler J, Mychaleckyj JC, Haffner SM, Norris JM, Bowden DW. Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study. 2009 (Epub 2008). Human Genetics 125:153-162.
Talbert ME, Langefeld CD, Ziegler J, Haffner SM, Norris JM, Bowden DW. INSIG2 SNPs Associated with Obesity and Glucose Homeostasis Traits in Hispanics: The IRAS Family Study. 2009. Obesity 2009 Aug;17(8):1554-62. Epub 2009 Apr 9.
Freidman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, and Robson SC. Functional ENTPD1 Polymorphisms in African-Americans with Diabetes and End-Stage Renal Disease. 2009 (Epub 2008). Diabetes 58(4):999-1006.
Norris JM, Langefeld CD, Talbert ME, Wing MR, Haritunians T, Fingerlin TE, Hanley AJG, Ziegler JT, Taylor KD, Haffner SM, Chen YI, Bowden DW, Wagenknecht LE Jill. Genome Wide Association Study and Follow-Up Analysis of Adiposity Traits in Hispanic-Americans: the IRAS Family Study. 2009. Obesity 2009 Oct;17(10):1932-41. Epub 2009 May 21.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.
Talbert ME, Wing MR, Palmer ND, Langefeld CD, Ziegler JT, Taylor K, Norris JM Haritunians T, Bryer-Ash M, Wagenknecht L, Bowden DW. Genome-Wide Association Study of Body Mass Index and Follow-up Candidate Genotyping in African Americans: the IRAS Family Study. To be presented at the annual meeting of the American Society of Human Genetics, October 2009, Honolulu, Hawaii.
Wing MR*, Talbert ME*, Palmer ND, Ziegler JT, Haritunians T, Taylor K, Langefeld CD, Bryer-Ash M, Bowden DW (*Co-Authorship). A GWAS of Adiposity Measures in African Americans: The IRAS Family Study. Presented at the annual meeting of the American Diabetes Association, June 2009, New Orleans, Louisiana.
Talbert ME, Langefeld CD, Norris JM, Haffner SM, and Bowden DW. Novel genetic association of SOCS3 with adiposity measures in Hispanics in the IRASFS. 1) Presented at the annual meeting of The American Society of Human Genetics, October 2007, San Diego, California. 2) Presented during Graduate Recruitment Day at Wake Forest Baptist Medical, February 2009, Winston-Salem, NC
Norris JM, Langefeld CD, Talbert ME, Wing MR, Haritunians T, Fingerlin TE, Hanley AJG, Ziegler JT, Taylor KD, Haffner SM, Chen YI, Bowden DW, Wagenknecht LE. Genome wide association study and follow-up analysis of visceral and subcutaneous abdominal fat in Hispanics: the IRAS Family Study. Presented at the annual meeting of The American Society of Human Genetics, October 2008, Philadelphia, Pennsylvania.
Langefeld CD, Talbert ME, Norris JM, Haffner SM, and Bowden DW. Glucose Homeostasis, Adiposity, and INSIG2: Genetic Analysis in the IRAS Family Study. 1) Presented at the annual meeting of The American Society of Human Genetics, October 2007, San Diego, California. 2) Presented at the annual Graduate Student Research Day of Wake Forest University, March 2008, Winston Salem, North Carolina.
Talbert ME, Guo Q. “Exploring the Alzheimer’s Proteome Utilizing a Novel Antibody Microarray Technology,” Wake Forest University, Summer Opportunities Program Poster Symposium, July 2004, Winston Salem, North Carolina.
INSIG2 SNPs Associated With Obesity and Glucose Homeostasis Traits in Hispanics: The IRAS Family Study. Society for Heart Attack Prevention and Eradication, Featured SHAPE Point, June 2009. http://www.shapesociety.org/June_Shape_Points
Gene Hunting in the Era of Genome-Wide Association Study: Obesity in Ethnic Minorities. North Carolina Agricultural and Technical University, Department of Biology Seminar, March 2009. Greensboro, NC
Searching for obesity genes on chromosome 17q: minority genetics in the IRASFS. North Carolina Agricultural and Technical University, Department of Biology Seminar, March 2008. Greensboro, NC
Unravelling the genetics of the human obesity epidemic. Davidson College Biology Departmental Seminar. September 27th, 2007. Davidson College. Davidson, NC.
Visiting Instructor/Consultant in Principles of Genetics Course
The Positional Cloning of Complex Disease Gene Series
North Carolina Agricultural & Technical University
Fall Semester 2008