Jill Elaine Wykosky, PhD


Staff Scientist
Takeda Pharmaceutical
Greater San Diego Area, CA 



Ph.D., Molecular Medicine and Translational Science Graduate Program, May 2008
Wake Forest University Graduate School of Arts and Sciences


Areas of specialization: Cancer Biology, Brain Tumor Biology

B.S., Microbiology with Honors in Biological Sciences, 1999-2003, Summa cum Laude
Related area, Chemistry
University of Pittsburgh, Pittsburgh, Pennsylvania,

Certified, Conceptual Foundations of Medicine

Research Interests:

The oncogenic role of signal transduction mediated by protein or lipid phosphatases as well as the differences between the signaling effected by oncogenic mutant receptors and their normal wild-type counterparts.


Wykosky J and Debinski W. Molecular Targeting of IL-13R2 and EphA2 Receptor in GBM. In: E.G. Van Meir (Ed.) CNS Cancer: Models, Prognostic Factors, and Targets. Dec 2008. Springer.

Wykosky J, Palma E, Gibo DM, Ringler S, Turner CP, and Debinski W. Soluble, monomeric ephrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene, advance online publication, 15 September 2008.

Wykosky J and Debinski W. Function and therapeutic targeting of the EphA2/ephrinA1 system in solid tumors. Molecular Cancer Research, 2008, In press.

Wykosky J, Gibo DM, Stanton C, and Debinski W. IL-13 Receptor alpha 2, EphA2, and Fra-1 as molecular denominators of high-grade astrocytomas. Clinical Cancer Research 14(1), 199-208, 2008.

Wykosky J, Gibo DM, and Debinski W. A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor expressing tumor cells. MolecularCancer Therapeutics 6(12): 3208-3218, 2007.

For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.


NRSA Pre-doctoral fellowship: NINDS, 2006-2008
F31 NSO55533-01 “EphA2: Function and Targeting in Malignant Gliomas”

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Contact Information
Molecular Medicine and Translational Science Graduate Program

Office 336-713-4259

Kay Collare



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