Residency Research Opportunities
Research and scientific discovery
are integral to Neurosurgery and encouraged as part of the well-rounded
training of a Neurosurgeon. The PGY 4 year is dedicated to research and
the Department has a Research Coordinator(s) who is available to assist with navigation
throughout the submission and approval process for human subject research and
- Protected PGY 4 year research
- Option to continue or translate
research in PGY5 year.
PGY 4 residents attend the RUNN
(Research Update in Neuroscience for Neurosurgeons) course which is funded
by the department
Dedicated Research Coordinator
- Data entry, statistics, and
manuscript preparation assistance available
are required to submit at least one paper (1) for publication each year of
residency and submit at least three (3) papers for publication during the
designated 12 month research year
will mentor PGY1 residents on call.
competency is maintained with (1) day per week in the OR and one weekend
call per week
mentor and Program Director meet in PGY 3 year to plan project and grant
residents have received over $1 million in funding over the past 3 years,
including NREF, DARPA, institutional and society funding.
Many opportunities exist for both
clinical and research projects dependent on the resident’s area of interest.
Tumor Center of Excellence (BTCOE),
under the direction of Dr. Waldemar Debinski, provides many potential
translational and collaborative research opportunities.
The BTCOE research plan includes priorities in the
discovery and development of new molecular anti-brain tumor therapies
(Molecular Therapeutics Group), understanding how radiation and other
treatments may cause brain injury (Modulation of Treatment Induced Brain
Injury/Quality of Life Group), the development of noninvasive means to
image brain tumors at the cellular and molecular levels (BioAnatomic
Imaging Group), and the use of preclinical models offered by large animals
such as dogs (Pre-Clinical Models of Disease Group).
Research efforts at the BTCOE are derived from the
collaboration of 7 departments along with Virginia Tech University.
Collaboration between Wake Forest University and Virginia
Tech University in biomedical engineering
also provides opportunities to participate in research at the Tyler
Neuroscience and Neurotechnology Laboratory, Human Neuroimaging Laboratory,
Computational Psychiatry Laboratory, Center for Injury Biomechanics, Laboratory
for Complex Brain Networks, and Advanced Neuroscience Imaging Research Core
Our Deep Brain Stimulation Program
has several clinical translational projects. These projects entail
collaborations with Virginia Tech University and Vanderbilt University.
Wake Forest is also an international leader in regenerative
medicine with a world renowned institute where researchers are working on
growing tissues and organs for more than 30 different areas of the body
including neurons and nerves. We were the first to create functional
solid and hollow organs such as a liver, kidney and bladder, as well as
spearheading a $75 million dollar project with the Armed Forces Institute of
Regenerative Medicine for battlefield Injuries.
The Wake Forest Innovation Center provides facilities and infrastructure for the generation
of biotech businesses from the transfer of technologies developed at Wake
Forest Laboratories. This unique center allows researchers to work with
entrepreneurs to develop new technologies for disease cures. Several clinical
projects exist currently in the area of spinal tools and technique development,
and collaboration with a human neuronal cell line for the treatment of
neuropathic pain is underway. Multiple members of the Neurosurgery department
have obtained over 40 patents.
Residents have access to the Kuka Robot, used in
conjunction with Virginia Tech-Wake Forest School of Biomedical Engineering, to
test biomechanical spine constructs.
Relevant Research Links
Center of Excellence
of Neuroengineering collaborative with Virginia Tech
Wake Forest Institute for
Wake Forest Innovation Center
Resident Publications for 2016-2017
1. Wicks RT, Jermakowicz WJ, Jagid JR, Couture DE, Willie JT, Laxton AW, Gross RE. Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy. Neurosurgery, Volume 79, Issue suppl_1, 1 December 2016, Pages S83–S91, https://doi.org/10.1227/NEU.0000000000001439
2. Renfrow JJ, Frenkel MB, Edwards MS, Wilson JA. Evaluation of a Traumatic Vertebral Artery Occlusion.
World Neurosurg. 2017 May;101:815.e13-815.e17. doi: 10.1016/j.wneu.2017.02.089. Epub 2017 Feb 27.
3. Wilson TA, Leslie-Mazwi T, Hirsch JA, Frey C, Kim TE, Spiotta AM, Leacy R, Mocco J, Albuquerque FC, Ducruet AF, Cheema A, Arthur A, Srinivasan VM, Kan P, Mokin M, Dumont T, Rai A, Singh J, Wolfe SQ, Fargen KM. A multicenter study evaluating the frequency and time requirement of mechanical thrombectomy. J Neurointerv Surg. 2017 Jun 9. pii: neurintsurg-2017-013147. doi: 10.1136/neurintsurg-2017-013147. [Epub ahead of print]
4. Renfrow JJ, Frenkel MB, Hsu W. Fungal Contamination of Methylprednisolone Causing Recurrent Lumbosacral Intradural Abscess. Emerg Infect Dis. 2017 Mar;23(3):552-553. doi:10.3201/eid2303.161334.
5. Renfrow JJ, Rodriguez A, Wilson TA, Germano IM, Abosch A, Wolfe SQ. Tracking Career Paths of Women in Neurosurgery. Neurosurgery. 2017 May 16. doi: 10.1093/neuros/nyx251. [Epub ahead of print]
6. Fargen KM, Soriano-Baron H, Rushing JT, Mack W, Mocco J, Albuquerque F, Ducruet AF, Mokin M, Linfante I, Wolfe SQ, Wilson JA, Hirsch JA. A survey of intracranial aneurysm treatment practices among United States physicians. J Neurointerv Surg. 2017 Feb 9. pii: neurintsurg-2016-012808. doi: 10.1136/neurintsurg-2016-012808. [Epub ahead of print]
7. Martinez-Del-Campo E, Turner JD, Soriano-Baron H, Newcomb AG, Kalb S, Theodore N.
Pediatric occipitocervical fusion: long-term radiographic changes in curvature, growth, and alignment.
J Neurosurg Pediatr. 2016 Nov;18(5):644-652. Epub 2016 Jul 29.
8. Martinez-Del-Campo E, Turner JD, Kalb S, Rangel-Castilla L, Perez-Orribo L, Soriano-Baron H, Theodore N. Occipitocervical Fixation: A Single Surgeon's Experience With 120 Patients. Neurosurgery. 2016 Oct;79(4):549-60. doi: 10.1227/NEU.0000000000001340.
9. Martinez-Del-Campo E, Turner JD, Rangel-Castilla L, Soriano-Baron H, Kalb S, Theodore N.Pediatric occipitocervical fixation: radiographic criteria, surgical technique, and clinical outcomes based on experience of a single surgeon. J Neurosurg Pediatr. 2016 Oct;18(4):452-462. Epub 2016 Jun 10.