Jian Shen, MD, PhD
Cornell University (Pharmacology)
Dr. Shen came to Wake Forest with a strong background in cell and molecular biology. Prior to Dr. Shen’s arrival, Dr. Koman and the Department had pioneered the use of botulinum toxin for the treatment of spasticity in children with cerebral palsy. However, the molecular response of the muscle and neuromuscular junction to botulinum toxin was unknown. Using both micro arrays and real-time PCR, Dr. Shen explored the molecular response of adult and immature muscle to both permanent denervation as well as temporary chemical denervation with botulinum toxin. In a series of elegant studies, Dr. Shen and the orthopaedic research lab characterized the molecular response of the muscle and the neuromuscular junction to both permanent denervation and temporary chemical denervation. This work resulted in numerous awards, presentations and publications. In addition, Dr. Shen also participated in clinical research, including examining the role of ulnar-positive variance for predicting TFCC injury. Dr. Shen was the lead investigator for a study examining release of the medial collateral ligament to improve flexion in post-traumatic elbow stiffness.
Spine Fellowship, University of California, San Francisco (2010-2011)
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.