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Kenneth L. Koch, M.D.

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Kenneth L. Koch, M.D.

Section Chief, Gastroenterology
Professor, Gastroenterology
Center for Diabetes Research
Institute for Regenerative Medicine

Clinical Specialties

Gastroenterology, Motility Disorders, Esophageal Disorders, Unexplained Nausea, Gastric Dysrhythmias, Vomiting Syndromes, Dyspepsia, Gastroparesis

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-7777
Department: 336-713-7306

Education & Training

  • M.D., University of Iowa College of Medicine, 1975
  • B.S., University of Iowa, 1970
  • Residency, Internal Medicine, Penn State U Affil Hosps, 1978
  • Fellowship, University of Florida, 1980

NPI Number

  • 1588649925
Kenneth L. Koch, M.D.

Request An Appointment

Kenneth L. Koch, M.D.

Section Chief, Gastroenterology
Professor, Gastroenterology Center for Diabetes Research
Institute for Regenerative Medicine

Contact Information

Department: 336-713-7306

Recent Publications

Orlando G, Bendala JD, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker S. Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut. 2013;62(5):774-786.

Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, Sarosiek I, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F. Cholecystectomy and clinical presentations of gastroparesis. Dig Dis Sci. 2013;58(4):1062-1073.

Hasler WL, Wilson LA, Parkman HP, Koch KL, Abell TL, Nguyen L, Pasricha PJ, Snape WJ, McCallum RW, Sarosiek I, Farrugia G, Calles J, Lee L, Tonascia J, Unalp-Arida A, Hamilton F. Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting. Neurogastroenterol Motil. 2013;25(5):427-e301.

Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229(1):155-160.

Parkman HP, Van Natta ML, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Snape WJ, Koch KL, Hasler WL, Farrugia G, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, Pasricha PJ. Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial. JAMA. 2013;310(24):2640-2649.


Benson PW, Hooker JB, Koch KL, Weinberg RB. Bitter taster status predicts susceptibility to vection-induced motion sickness and nausea. Neurogastroenterol Motil. 2012;24(2):134-40,e86.

Grover M, Bernard CE, Pasricha PJ, Lurken MS, Faussone-Pellegrini MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, McCallum RW, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Unalp-Arida A, Hamilton FA, Farrugia G. Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium. Neurogastroenterol Motil. 2012;24(6):531-e249.

Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,. Regenerative medicine as applied to general surgery. Ann Surg. 2012;255(5):867-880.

Parkman HP, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, McCallum RW, Yates K, Lee L, Unaip-Arida A, Tonascia J, Hamilton F. Diabetic gastroparesis: myth or reality? [reply to letter]. Clin Gastroenterol Hepatol. 2012;10(6):686-687.

Faussone-Pellegrini MS, Grover M, Pasricha PJ, Bernard CE, Lurken MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, Unalp-Arida A, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Hamilton FA, Farrugia G. Ultrastructural differences between diabetic and idiopathic gastroparesis. J Cell Mol Med. 2012;16(7):1573-1581.

Outlaw WM, Ibdah JA, Koch KL. Hyperemesis gravidarum and maternal liver disease In: Ibdah JA, ed. Maternal liver disease. Austin (TX): Landes Bioscience;2012: .

Hasler W, May P, Pasricha P, Parkman H, Abell T, Koch K, McCallum R, Sarosiek I, Nguyen L, Snape W, Calles J, Farrugia G, Tonascia J, Lee L, Unalp-Arida A, Hamilton F. Correlates of temporal variability of symptoms in gastroparesis [abstract]. Neurogastroenterol Motil. 2012;24(Suppl 2):18-19.

Parkman H, Wilson L, Pasricha P, Koch K, Shape W, Abell T, Hasler W, Lee L, Nguyen L, McCallum R, Sarosiek I, Farrugia G, Unalp-Arida A, Tonascia J, Hamilton F. Reconfiguring the Gastroparesis Cardinal Symptom Index (GCSI) [abstract]. Neurogastroenterol Motil. 2012;24(Suppl 2):19.

Koch KL, Bitar KN, Fortunato JE. Tissue engineering for neuromuscular disorders of the gastrointestinal tract. World J Gastroenterol. 2012;18(47):6918-6925.

Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Abell TL, McCallum RW, et al. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 2011;140(1):101-115.

des Gachons CP, Beauchamp GK, Stern RM, Koch KL, Breslin PAS. Bitter taste induces nausea [letter]. Curr Biol. 2011;21(7):R247-R248.

Stern RM, Koch KL, Andrews PLR. In: Nausea: mechanisms and management. New York: Oxford University Press;2011: .

Grover M, Farrugia G, Lurken MS, Bernard CE, Faussone-Pellegrini MS, Smyrk TC, Parkman HP, Abell TL, Koch KL, Calles J, et al. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology. 2011;140(5):1575-1585.

Koch KL. Unfulfilled wishes by gastric electrical stimulation [reply to letter]. Clin Gastroenterol Hepatol. 2011;9(5):449.

Parkman HP, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Abell TL, McCallum RW, Yates K, et al. Idiopathic gastroparesis or functional dyspepsia with delayed gastric emptying: where is the difference? [reply to letter]. Gastroenterology. 2011;140(7):2146-2148.

Pasricha PJ, Colvin R, Yates K, Hasler WL, Abell TL, Unalp-Arida A, Nguyen L, Farrugia G, Koch KL, Parkman HP, et al. Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clin Gastroenterol Hepatol. 2011;9(7):567-576.

Hasler WL, Wilson LA, Parkman HP, Nguyen L, Abell TL, Koch KL, Pasricha PJ, Snape WJ, Farrugia G, Lee L, et al. Bloating in gastroparesis: severity, impact, and associated factors. Am J Gastroenterol. 2011;106(8):1492-1502.

Koch KL. The electrifying stomach. Neurogastroenterol Motil. 2011;23(9):815-818.

Parkman HP, Yates KP, Hasler WL, Nguyan L, Pasricha PJ, Snape WJ, Farrugia G, Calles J, Koch KL, Abell TL, et al. Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis. Gastroenterology. 2011;141(2):486-498.

Fortunato JE, Shaltout HA, Larkin MM, Rowe PC, Diz DI, Koch KL. Fludrocortisone improves nausea in children with orthostatic intolerance (OI). Clin Auton Res. 2011;21(6):419-423.

Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F. Similarities and differences between diabetic and idiopathic gastroparesis. Clin Gastroenterol Hepatol. 2011;9(12):1056-1064.

Kundu S, Koch K. Effect of balloon distension or botulinum toxin A injection of the pylorus on symptoms and body weight in patients with gastroparesis with normal 3 cycle per minute gastric electrical activity [abstract]. Am J Gastroenterol. 2011;106(Suppl 2):S35.

Fortunato JE Jr, Shaltout HA, Diz DI, Koch KL. Chronic idiopathic nausea in children associated with orthostatic intolerance improves after treatment with fludrocortisone [abstract]. Gastroenterology. 2011;140(5 Suppl 1):S-743.

Saad RJ, Rao SSC, Koch KL, Kuo B, Parkman HP, McCallum RW, Sitrin MD, Wilding GE, Semler JR, Chey WD. Do stool form and frequency correlate with whole-gut and colonic transit ? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol. 2010;105(2):403-411.

Kloetzer L, Chey WD, McCallum RW, Koch KL, Wo JM, Sitrin M, Katz LA, Lackner JM, Parkman HP, Wilding GE, et al. Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule. Neurogastroenterol Motil. 2010;22(5):527-533.

Selim MM, Wendelschafer-Crabb G, Redmon JB, Khoruts A, Hodges JS, Koch K, Walk D, Kennedy WR. Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy?. Neurology. 2010;75(11):973-981.

Hasler WL, Parkman HP, Wilson LA, Pasricha PJ, Koch KL, Abell TL, Snape WJ, Farrugia G, Lee L, Tonascia J, et al. Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis. Am J Gastroenterol. 2010;105(11):2357-2367.

Koch KL. Gastric electrical stimulation and the 'eye of the beholder' [editorial]. Clin Gastroenterol Hepatol. 2010;8(11):908-909.

Butler SG, Stuart A, Castell D, Russell GB, Koch K, Kemp S. Effects of age, gender, bolus condition, viscosity, and volume on pharyngeal and upper esophageal sphincter pressure and temporal measurements during swallowing. J Speech Lang Hear Res. 2009;52(1):240-253.

Hasler WL, Saad RJ, Rao SS, Wilding GE, Parkman HP, Koch KL, McCallum RW, Kuo B, Sarosiek I, Sitrin MD, et al. Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS. Am J Physiol Gastrointest Liver Physiol. 2009;297(6):G1107-1114.

Hasler W, Parkman H, Wilson L, Abell T, Snape W, Koch K, Pasricha P, Tonascia J. Bloating in gastroparesis: prevalence, impact and associated factors [abstract]. Am J Gastroenterol. 2009;104(Suppl 3):S58.

Koch K, Hasler W, Calles J, Parkman H, Pasricha P, Abell T, Snape W, Colvin R, Tonascia J. Diabetic gastroparesis: comparison of clinical features in patients with type 2 (T2DM) and type 1 (T1DM) diabetes mellitus [abstract]. Am J Gastroenterol. 2009;104(Suppl 3):S56.

Thorne N, Kundu S, Vadlamudi R, Ervin S, Feldman J, Koch K. Hospitalized patients with chronic abdominal pain are frequently prescribed narcotic analgesics without pain management and/or psychiatric evaluation [abstract]. Am J Gastroenterol. 2009;104(Suppl 3):S408.

Kuo B, McCallum RW, Koch KL, Sitrin MD, Wo JM, Chey WD, Hasler WL, Lackner JM, Katz LA, Semler JR, et al. Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. Aliment Pharmacol Ther. 2008;27(2):186-196.

Hasler WL, Coleski R, Chey WD, Koch KL, McCallum RW, Wo JM, Kuo B, Sitrin MD, Katz LA, Hwang J, et al. Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention. Am J Physiol Gastrointest Liver Physiol. 2008;294(6):G1384-1391.

Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, Koch KL. Protein and ginger for the treatment of chemotherapy-induced delayed nausea. J Altern Complement Med. 2008;14(5):545-551.

Parkman HP, Hutson A, Katz L, Sitrin M, Kuo B, Sarosiek I, McCallum RW, Chey WD, Hasler W, Koch K, et al. Relationship of body mass index (BMI) to gastric emptying of digestible and nondigestible solids [abstract]. Neurogastroenterol Motil. 2007;19(5):430.

Sarosiek I, Parkman H, Kuo B, Hutson A, Lackner J, Katz L, Sitrin M, Sarosiek J, Chey WD, Koch K, et al. SmartPill as a unique tool for an insight into the relationship between transit times within the upper and the lower alimentary tract in health and disease [abstract]. Neurogastroenterol Motil. 2007;19(5):432.

Levine ME, Holt L, Koch KL. Effects of soy, casein, and whey protein-predominant drinks on gastric myoelectrical activity and postprandial symptoms of fullness and satiety [abstract]. Neurogastroenterol Motil. 2007;19(6):526-527.

Intagliata N, Koch KL. Gastroparesis in type 2 diabetes mellitus: prevalence, etiology, diagnosis, and treatment. Curr Gastroenterol Rep. 2007;9(4):270-279.

Butler SG, Stuart A, Castell D, Russell G, Koch K, Kemp S. Effects of age, gender, bolus volume, condition, viscosity, and volume on pharyngeal and upper esophageal sphincter pressure and temporal measurements during swallowing [abstract]. Dysphagia. 2007;22(4):367.

Outlaw WM, Koch KL. Dyspepsia and its overlap with irritable bowel syndrome. Curr Gastroenterol Rep. 2006;8(4):266-272.

Talley NJ, Camilleri M, Burton D, Thomforde G, Koch K, Rucker MJ, Peterson J, Zinsmeister AR, Earnest DL. Double-blind, randomized, placebo-controlled study to evaluate the effects of tegaserod on gastric motor, sensory and myoelectric function in healthy volunteers. Aliment Pharmacol Ther. 2006;24(5):859-867.

Stern RM, Koch KL. Understanding nausea. Ann Acad Med Siles. 2006;60(3):175-182.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gastroenterology

Clinical Specialties

Gastroenterology, Motility Disorders, Esophageal Disorders, Unexplained Nausea, Gastric Dysrhythmias, Vomiting Syndromes, Dyspepsia, Gastroparesis