Profile

Profile
Research

Weiling Zhao, Ph.D.

Assistant Professor, Radiation Oncology
Comprehensive Cancer Center
Brain Tumor Center of Excellence
Neurosurgery

Contact Information

Academic: 336-713-7633 | Department: 336-713-3600

Email: wzhao@wakehealth.edu

Education & Training

Ph.D., University of Iowa College of Medicine, 2000
B.S., Non Medical School-China, 1982
M.S., University of Iowa College of Medicine, 1998

Weiling Zhao, Ph.D.

Assistant Professor, Radiation Oncology Comprehensive Cancer Center
Brain Tumor Center of Excellence
Neurosurgery

Research Interests

drugs/therapeutic agents pharm, immunology/allergy/inflammatio, prevention

Contact Information

Academic: 336-713-7633 | Department: 336-713-3600

Email: wzhao@wakehealth.edu

Recent Publications

Almeida C, Nagarajan D, Tian J, Leal SW, Wheeler K, Munley M, Blackstock W, Zhao W. The role of alveolar epithelium in radiation-induced lung injury. PLoS One. 2013;8(1):e53628.

Nagarajan D, Melo T, Deng Z, Almeida C, Zhao W. ERK/GSK3beta/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition. Free Radic Biol Med. 2012;52(6):983-992.

Deng Z, Sui G, Rosa PM, Zhao W. Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells. PLoS ONE. 2012;7(5):e36739.

Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu F-C, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res. 2012;178(1):46-56.

Tian J, Zhao W, Tian S, Slater JM, Deng Z, Gridley DS. Expression of genes involved in mouse lung cell differentiation/regulation after acute exposure to photons and protons with or without low-dose preirradiation. Radiat Res. 2011;176(5):553-564.

Ramanan S, Zhao W, Riddle DR, Robbins ME. Role of PPARs in radiation-induced brain injury. PPAR Res. 2010;2010():art.234975.

Robbins ME, Zhao W, Garcia-Espinosa MA Diz DI. Renin-angiotensin system blockers and modulation of radiation-induced brain injury. Curr Drug Targets. 2010;11(11):1413-1422.

Zhao W, Toler SM, Lippiello PM, Bencherif M. A7 nicotinic receptor agonist enhances neurogenesis and reduces brain inflammation after lipopolysaccharide (LPS) or radiation treatment [abstract]. Eur Neuropsychopharmacol. 2010;20(Suppl 3):S242.

Robbins ME, Payne V, Tommasi E, Diz DI, Hsu F-C, Brown WR, Wheeler KT, Olson J, Zhao W. The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys. 2009;73(2):499-505.

Zhao W, Robbins ME. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem. 2009;16(2):130-143.

Ramanan S, Kooshki M, Zhao W, Hsu F-C, Riddle DR, Robbins ME. The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. Int J Radiat Oncol Biol Phys. 2009;75(3):870-877.

Collins-Underwood JR, Zhao W, Sharpe JG, Robbins ME. NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Free Radic Biol Med. 2008;45(6):929-938.

Smith-Pearson PS, Kooshki M, Spitz DR, Poole LB, Zhao W, Robbins ME. Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H2O2. Free Radic Biol Med. 2008;45(8):1178-1189.

Ramanan S, Kooshki M, Zhao W, Hsu F-C, Robbins ME. PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Free Radic Biol Med. 2008;45(12):1695-1704.

Robbins M, Payne V, Diz D, Hsu FC, Zhao WL. Chronic inhibition of the renin-angiotensin system prevents radiation-induced cognitive impairment in the adult male rat [abstract]. Neuro Oncol. 2008;10(5):851.

Zhao W, Payne V, Tommasi E, Diz DI, Hsu F-C, Robbins ME. Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys. 2007;67(1):6-9.

Smith PS, Zhao W, Spitz DR, Robbins ME. Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress. Free Radic Biol Med. 2007;42(6):787-797.

Zhao W, Iskandar S, Kooshki M, Sharpe JG, Payne V, Robbins ME. Knocking out peroxisome proliferator-activated receptor (PPAR) alpha inhibits radiation-induced apoptosis in the mouse kidney through activation of NF-kappaB and increased expression of IAPs. Radiat Res. 2007;167(5):581-591.

Zhao W, Diz DI, Robbins ME. Oxidative damage pathways in relation to normal tissue injury. Br J Radiol. 2007;80(Special Issue 1):S23-S31.

Atwood T, Payne VS, Zhao W, Brown WR, Wheeler KT, Zhu J-M, Robbins ME. Quantitative magnetic resonance spectroscopy reveals a potential relationship between radiation-induced changes in rat brain metabolites and cognitive impairment. Radiat Res. 2007;168(5):574-581.

Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S, Robbins M. Fatty acid synthase: a novel target for antiglioma therapy. Br J Cancer. 2006;95(7):869-878.

Collins-Underwood JR, Zhao W, Kooshki M, Robbins M. Role of NADPH oxidase in radiation-induced oxidative stress and inflammation in brain endothelium [abstract]. Free Radic Res. 2006;40(Suppl 1):S52.

Smith PS, Zhao W, Robbins M. Knocking down catalase increases sensitivity of gliomas to oxidative stress [abstract]. Free Radic Res. 2006;40(Suppl 1):S70.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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All

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Radiation Oncology