Primary Faculty: Cancer Biology

Elizabeth Alli, PhD My research focuses on manipulating tumorigenic mechanisms that involve oxidative damage and response pathways for purposes of cancer chemoprevention and therapy.  Faculty Page  Laboratory Page

Yong Q. Chen, PhD My research focuses on two areas of prostate cancer; (1) genetic basis and lipid signaling in prostate cancer development, and (2) effect of dietary fat on prostate cancer development in genetically predisposed populations.  Faculty Page  Laboratory Page

Gagan Deep, PhD My research focuses on cancer prevention, exosomes, and health disparities among patients with prostate cancer.  Faculty Page Laboratory Page

William H. Gmeiner, PhD, MBA  Research in my laboratory is focused on developing novel cytotoxic oligodeoxynucleotides (ODNs) for treatment of prostate cancer and other malignancies and in understanding the role of DNA structure in carcinogenesis and cancer chemotherapy.  Faculty Page  Laboratory Page

Bethany Kerr, PhD  My lab focuses on discovering the mechanisms controlling the initiation and progression of bone metastasis.  By examining how tumor progression results in the production of disseminated tumor cells and how these cells survive in the circulation and home to the bone microenvironment, we hope to develop novel prognostic tests to identify patients likely to progress to metastasis and new treatments to prevent or slow bone metastasis.  Faculty Page  Laboratory Page

Steven Kridel, PhD  Research in my lab focuses on understanding the regulation of pathways that control fatty acid synthesis by fatty acid synthase in prostate cancer.  Faculty Page  Laboratory Page

George Kulik, PhD  My laboratory is focusing on signal transduction mechanisms that protect prostate cancer cells from apoptosis. This information is necessary to design more effective therapies for advanced prostate cancer and other therapy resistant cancers.  Faculty Page  Laboratory Page

Hui-Kuan Lin, PhD  The research focus in my lab is to dissect the roles of ubiquitination pathways in cancer progression, metastasis and cancer stem cell regulation using biochemical and molecular biology approaches along with genetic mouse models. The ultimate goals are to gain better understanding the biology of cancer and  to develop small molecule inhibitors for cancer therapy.  Faculty Page  Laboratory Page

Hui-Wen Lo, PhD  My research program is focused on understanding the molecular pathways that regulate tumor progression, metastasis and therapeutic response.  Faculty Page  Laboratory Page

Lance D. Miller, PhD  Using genomic technologies such as DNA microarrays, my laboratory investigates the transcriptional dynamics and genomic architectures of primary tumors to uncover novel prognostic biomarkers and mechanisms of disease progression.  Faculty Page  Laboratory Page

Boris Pasche, MD, PhD, FACP  Dr. Pasche specializes in the treatment of gastrointestinal malignancies including colon and rectal cancer, pancreatic cancer, gastric cancer, cholangiocarcinoma, hepatocellular carcinoma, and esophageal cancer.  Faculty Page  Laboratory Page

Neveen Said, MD, PhD  My research focuses on understanding the role of matricellular proteins as modulators of the dynamic cell-cell interactions in the tumor microenvironment during the multistep cascades of cancer initiation, progression, and organ-specific metastasis. The ultimate goal is understand the mechanisms of tumor heterogeneity and uncover novel diagnostic and prognostic biomarkers of cancer progression that can be used for patient stratification for personalized cancer therapy.  Faculty Page  Laboratory Page

Yusuke Shiozawa, MD, PhD  The Shiozawa Lab is interested in prostate cancer and its metastatic preference for bone.  Current research is focused on identifying the mechanisms by which tumor cells that disseminate from primary tumors “communicate” with the bone marrow microenvironment and how this crosstalk affects tumor dormancy, recurrence, and complications of bone metastases.  Our goal is to use information about these interactions to develop efficient treatments for bone metastatic disease.  Faculty Page  Laboratory Page

Ravi Singh, PhD  The focus of my research is the integration of specific clinical applications into the development of nanotechnology-based, multifunctional units designed to diagnose cancer, deliver therapeutic agents, and monitor cancer treatment (so called “theranostic” agents).  Faculty Page  Laboratory Page

Peiqing Sun, PhD  The research in my laboratory focuses on dissecting the signal transduction pathways that mediate oncogene-induced senescense and other tumor suppressing defense mechanisms in mammals, suing cell culture and animal models.  Faculty Page  Laboratory Page

Pierre-Alexandre Vidi, PhD  Research in my laboratory examines how signaling from the cellular microenvironment influences nuclear organization and DNA repair in the context of breast cancer initiation and progression.  Faculty Page  Laboratory Page

Thad Wadas, PhD  Our research program utilizes the tools of molecular biology, chemistry and radiochemistry to develop targeted agents for cancer detection and therapy.  Faculty Page    Laboratory Page  

Kounosuke Watabe, PhD  Current research in the Watabe lab are tumor microenvironment, metastasis, cancer stem cells and non-coding RNA in breast and prostate cancers.  Faculty Page  Laboratory Page

Fei Xing, PhD  My research is focused on understanding the role of tumor microenvironment in breast cancer brain metastasis.  Faculty Page  Laboratory Page​

Wei Zhang, PhD My long-term goal is to uncover the key regulatory molecules whose alteration drives cancer development and progression. These driver events should provide the best points of therapeutic intervention, with the end result of significantly improved patient survival and quality of life. Functional genomics and systems biology research conducted over the past 18 years by my group has identified multiple novel cancer markers and oncogenic signaling molecules that are under extensive characterization and investigation.  Faculty Page  Laboratory Page

 

Quick Reference

Cancer Biology

Telephone 336-716-9132

Fax 336-716-0255

E-mail
bbottoms@wakehealth.edu
Graduate Program E-mail
skridel@wakehealth.edu

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Last Updated: 08-26-2016
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