Steven A. Akman, MD My laboratory is interested in DNA damage and mutagenesis. Faculty Page Laboratory Page
Isabelle Berquin, PhD My laboratory is currently investigating the mechanism by which YB-1 promotes breast cancer, and the effect of dietary lipids on breast and prostate cancer risk. Faculty Page Laboratory Page
Yong Q. Chen, PhD My research focuses on two areas of prostate cancer; (1) genetic basis and lipid signaling in prostate cancer development, and (2) effect of dietary fat on prostate cancer development in genetically predisposed populations. Faculty Page Laboratory Page
Scott D. Cramer, PhD The current focus of my research is on the molecular dissection of signaling pathways in prostatic cells, the identification of prostate progenitor or stem cells, and understanding epithelial-stromal interactions in normal and abnormal ductal morphogenesis. Faculty Page Laboratory Page
William H. Gmeiner, PhD, MBA Research in my laboratory is focused on developing novel cytotoxic oligodeoxynucleotides (ODNs) for treatment of prostate cancer and other malignancies and in understanding the role of DNA structure in carcinogenesis and cancer chemotherapy. Faculty Page Laboratory Page
Steven Kridel, PhD Research in my lab focuses on understanding the regulation of pathways that control fatty acid synthesis by fatty acid synthase in prostate cancer. Faculty Page Laboratory Page
George Kulik, PhD My laboratory is focusing on signal transduction mechanisms that protect prostate cancer cells from apoptosis. This information is necessary to design more effective therapies for advanced prostate cancer and other therapy resistant cancers. Faculty Page Laboratory Page
Lance D. Miller, PhD Using genomic technologies such as DNA microarrays, my laboratory investigates the transcriptional dynamics and genomic architectures of primary tumors to uncover novel prognostic biomarkers and mechanisms of disease progression. Faculty Page Laboratory Page
Mark Miller, PhD Research in my laboratory is examining environmental/genetic interactions that affect an organism’s susceptibility to lung cancer formation, utilizing a variety of in vivo models and molecular biological techniques. Faculty Page Laboratory Page
Karin D. Scarpinato, PhD One of the main DNA repair pathways, mismatch repair (MMR) significantly contributes to the maintenance of genome stability and the elimination of extensively damaged cells. Laboratory Page
Gary G. Schwartz, PhD, MPH, PhD We have suggested that the descriptive epidemiology of prostate cancer, i.e., the increasing risk with age, Black race, and residence at northern latitudes, resemble the descriptive epidemiology of vitamin D deficiency in the elderly. Faculty Page Laboratory Page
Darren F. Seals, PhD Our lab is interested in the basic mechanisms of cell migration and invasion, particularly as it relates to tumor growth and metastasis. Faculty Page Laboratory Page
Guangchao Sui, PhD The research in our lab focuses on the molecular mechanisms of the epigenetic regulation of tumorigenesis. Faculty Page Laboratory Page
Frank Torti, MD The Frank Torti Laboratory is interested in cytokines, such as tumor necrosis factor alpha (TNF), as well as oxidative stress and DNA Damaging agents, such as radiation and chemotherapeutic agents and how they differentially affect the iron homeostatic mechanisms of normal cells and cancer cells. Faculty Page Laboratory Page
Jim Vaughn, PhD The Vaughn laboratory is focused on assaying the anti-tumor therapeutic potential of new classes of chemically modified DNA oligonucleotides. Faculty Page Laboratory Page